Novel effects of nitric oxide

Davis, K. L.; Martin, E.; Turko, I. V.; Murad, F.

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NASA NTRS · 20040112511

Novel effects of nitric oxide

Davis, K. L.·Martin, E.·Turko, I. V.·Murad, F.

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Abstract

Nitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many of these effects. However, NO can also interact with molecular oxygen and superoxide radicals to produce reactive nitrogen species that can modify a number of macromolecules including proteins, lipids, and nucleic acids. NO can also interact directly with transition metals. Here, we have reviewed the non--3',5'-cyclic-guanosine-monophosphate-mediated effects of NO including modifications of proteins, lipids, and nucleic acids.

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Non-NASA Center Review Review, Academic NASA Discipline Cardiopulmonary Nitric Oxide/chemistry/pharmacology/physiology Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S Metals/metabolism Support, U.S. Gov't, P.H.S Proteins/chemistry/drug effects Animals Human

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Davis, K. L., Martin, E., Turko, I. V., Murad, F.. 2001-01-01. Novel effects of nitric oxide. https://ntrs.nasa.gov/citations/20040112511

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