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NASA NTRS · 20050000744

Long-range correlations in nucleotide sequences

Peng, C. K.·Buldyrev, S. V.·Goldberger, A. L.·Havlin, S.·Sciortino, F.·Simons, M.·Stanley, H. E.
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Abstract

DNA sequences have been analysed using models, such as an n-step Markov chain, that incorporate the possibility of short-range nucleotide correlations. We propose here a method for studying the stochastic properties of nucleotide sequences by constructing a 1:1 map of the nucleotide sequence onto a walk, which we term a 'DNA walk'. We then use the mapping to provide a quantitative measure of the correlation between nucleotides over long distances along the DNA chain. Thus we uncover in the nucleotide sequence a remarkably long-range power law correlation that implies a new scale-invariant property of DNA. We find such long-range correlations in intron-containing genes and in nontranscribed regulatory DNA sequences, but not in complementary DNA sequences or intron-less genes.

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NASA Discipline CardiopulmonaryNon-NASA CenterNucleotide MappingDNA/chemistrySupport, U.S. Gov't, Non-P.H.SSupport, U.S. Gov't, P.H.SHumanAnimalsComparative StudyStatisticsRegulatory Sequences, Nucleic AcidSupport, Non-U.S. Gov'tBase SequenceIntrons

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Peng, C. K., Buldyrev, S. V., Goldberger, A. L., Havlin, S., Sciortino, F., Simons, M., Stanley, H. E.. 1992-03-12. Long-range correlations in nucleotide sequences. https://ntrs.nasa.gov/citations/20050000744

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