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DOE OSTI · 1629350

Sequential exposure to specific antibody escape mutations may program neutralization breadth during subtype A HIV-1 infection

Murphy, M. K.·Yue, L.·Pan, R.·Boliar, S.·Sethi, A.·Karita, E.·Allen, S. A.·Cormier, E.·Robinson, J. E.·Gnanakaran, S.·Hunter, E.·Kong, X.·Derdeyn, C. A.
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Abstract

Mechanisms that expand the otherwise narrow neutralization capacity observed during early HIV-1 infection are currently undefined, but multiple lines of evidence suggest that the ability to elicit broad and potent neutralizing antibodies (nAbs) via vaccination could increase the protective efficacy of immunization.

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59 BASIC BIOLOGICAL SCIENCESautologous plasmaearly escapeimmunoglobulin light chainneutralization targetsingle amino acid change

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Murphy, M. K., Yue, L., Pan, R., Boliar, S., Sethi, A., Karita, E., Allen, S. A., Cormier, E., Robinson, J. E., Gnanakaran, S., Hunter, E., Kong, X., Derdeyn, C. A.. 2012-09-13. Sequential exposure to specific antibody escape mutations may program neutralization breadth during subtype A HIV-1 infection. https://doi.org/10.1186/1742-4690-9-s2-p104

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