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DOE OSTI · 1801459

Single-entity electrochemistry at confined sensing interfaces

Ying, Yi-Lun·Wang, Jiajun·Leach, Anna Rose·Jiang, Ying·Gao, Rui·Xu, Cong·Edwards, Martin A.·Pendergast, Andrew D.·Ren, Hang·Weatherly, Connor Terry·Wang, Wei·Actis, Paolo·Mao, Lanqun·White, Henry S.·Long, Yi-Tao
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Abstract

Measurements at the single-entity level provide more precise diagnosis and understanding of basic biological and chemical processes. Recent advances in the chemical measurement provide a means for ultra-sensitive analysis. Confining the single analyte and electrons near the sensing interface can greatly enhance the sensitivity and selectivity. In this work, we summarize the recent progress in single-entity electrochemistry of single molecules, single particles, single cells and even brain analysis. The benefits of confining these entities to a compatible size sensing interface are exemplified. Finally, the opportunities and challenges of single entity electrochemistry are addressed.

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRYbrainchemistryconfining effectelectrochemistrynanoparticlesnanoporessensorssingle cellsingle entity

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Ying, Yi-Lun, Wang, Jiajun, Leach, Anna Rose, Jiang, Ying, Gao, Rui, Xu, Cong, Edwards, Martin A., Pendergast, Andrew D., Ren, Hang, Weatherly, Connor Terry, Wang, Wei, Actis, Paolo, Mao, Lanqun, White, Henry S., Long, Yi-Tao. 2020-04-03. Single-entity electrochemistry at confined sensing interfaces. https://doi.org/10.1007/s11426-020-9716-2

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