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DOE OSTI · 1816290

Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic–bomb survivors

Yoshida, Kengo·Misumi, Munechika·Kusunoki, Yoichiro·Yamada, Michiko
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Abstract

Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by examining longitudinal RDW changes in 4204 atomic-bomb survivors over 15 years. A positive association was found between RDW and radiation dose, wherein RDW increased by 0·18%/Gy. This radiation-associated effect increased as the participants aged. Elevated RDW was also associated with higher all-cause mortality. The biological mechanisms underlying these observed associations merit further investigation.

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.

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Yoshida, Kengo, Misumi, Munechika, Kusunoki, Yoichiro, Yamada, Michiko. 2020-12-22. Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic–bomb survivors. https://doi.org/10.1111/bjh.17296

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