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DOE OSTI · 3362863

Data for 3-Hydroxypropionic Acid Recovery from Fermentation Broth through Novel Downstream Processing: Technoeconomic Analysis

Mahata, Chandan [Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA] (ORCID:0000000279743012)·Mishra, Somesh [Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA] (ORCID:0000000173409542)·Singh, Vijay [Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA]
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Abstract

This study develops and validates a simplified, fully solvent-free downstream processing (DSP) strategy for high-purity recovery of 3-hydroxypropionic acid (3-HP) from real fermentation broth containing 62.3 g/L of 3-HP. Optimized activated carbon treatment achieved 98% color removal, while Amberlite IRA-67 was operated at pH 4.5 and 30 °C to minimize product loss. This is the first integrated demonstration of a fully solvent-free DSP enabling recovery of bio-based 3-HP as both a solid sodium salt and a concentrated aqueous solution, supported by techno-economic analysis. At lab scale, the process achieved 77.3% recovery of sodium 3-HP with 83.2% (w/w) purity and produced a 30% (w/v) aqueous solution. Techno-economic analysis yielded minimum selling prices of $0.551/kg for the solution and $0.892/kg for the salt, both below target thresholds for cost-competitive bio-acrylic acid production. Overall, these results demonstrate an efficient, scalable, and economically viable industrial pathway for 3-HP recovery.

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Mahata, Chandan [Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA] (ORCID:0000000279743012), Mishra, Somesh [Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA] (ORCID:0000000173409542), Singh, Vijay [Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA]. 2026-04-09. Data for 3-Hydroxypropionic Acid Recovery from Fermentation Broth through Novel Downstream Processing: Technoeconomic Analysis. https://doi.org/10.13012/b2idb-9358844_v1

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