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At least 199 records · Page 11

Prospects of a mathematical theory of human behavior in complex man-machine systems tasks

A hierarchy of human activities is derived by analyzing automobile driving in general terms. A structural description leads to a block diagram and a time-sharing computer analogy. The range of applicability of existing mathematical models is considered with respect to the hierarchy of human activities in actual complex tasks. Other mathematical tools so far not often applied to man machine systems are also discussed. The mathematical descriptions at least briefly considered here include utility, estimation, control, queueing, and fuzzy set theory as well as artificial intelligence techniques. Some thoughts are given as to how these methods might be integrated and how further work might be pursued.

Johannsen, G.↗

Left ventricular endocardial surface detection based on real-time 3D echocardiographic data

OBJECTIVE: A new computerized semi-automatic method for left ventricular (LV) chamber segmentation is presented. METHODS: The LV is imaged by real-time three-dimensional echocardiography (RT3DE). The surface detection model, based on level set techniques, is applied to RT3DE data for image analysis. The modified level set partial differential equation we use is solved by applying numerical methods for conservation laws. The initial conditions are manually established on some slices of the entire volume. The solution obtained for each slice is a contour line corresponding with the boundary between LV cavity and LV endocardium. RESULTS: The mathematical model has been applied to sequences of frames of human hearts (volume range: 34-109 ml) imaged by 2D and reconstructed off-line and RT3DE data. Volume estimation obtained by this new semi-automatic method shows an excellent correlation with those obtained by manual tracing (r = 0.992). Dynamic change of LV volume during the cardiac cycle is also obtained. CONCLUSION: The volume estimation method is accurate; edge based segmentation, image completion and volume reconstruction can be accomplished. The visualization technique also allows to navigate into the reconstructed volume and to display any section of the volume.

Non-NASA Center↗

Model order reduction applied to a hot-bench simulation of an aeroelastic wind-tunnel model

Simulations of an aeroelastically scaled wind-tunnel model were developed for hot-bench testing of a digital controller. The digital controller provided active flutter-suppression, rolling-maneuver-load alleviation, and plant estimation. To achieve an acceptable time scale for the hot-bench application, the mathematical model of the wind-tunnel model was reduced from 220 states to approximately 130 states while assuring that the required accuracy was preserved for all combinations of 10 inputs and 56 outputs. The reduction was achieved by focussing on a linear, aeroelastic submodel of the full mathematical model and by applying a method based on the internally balanced realization of a dynamic system. The error-bound properties of the internally balanced realization significantly contribute to its utility in the model reduction process. The reduction method and the results achieved are described.

Buttrill, Carey S.↗

A mathematical framework for thermodynamic computing with applications to chemical reaction networks

The widespread adoption of energy-intensive computing applications has led to a growing need for energy-efficient computing approaches. Thermodynamic computing offers a promising approach for low-energy computation by leveraging the intrinsic computational capabilities of physical, chemical, or biological systems. However, the mathematical foundations of thermodynamic computing require further development to fully realize the potential energy efficiencies, as well as to assess factors like noise and operational speed. In this paper, we establish a mathematical framework for utilizing thermodynamic processes to perform fundamental operations, including addition, subtraction, multiplication, and division. We highlight the use of chemical reactions as potential computational units and explore synthetic chemical and biochemical systems as practical implementations. Additionally, we demonstrate how these principles can be applied to solving complex mathematical problems, such as ordinary differential equations (ODEs) and suggest the necessary components to implement the thermodynamic computing framework using chemical reactions based in a microfluidic device. This work enhances our understanding of thermodynamic processes for natural computing as a basis for scalable, energy-efficient computation in paradigm disruptive next-generation systems.

Cannon, William R. [Pacific Northwest National Lab↗

The flow of plasma in the solar terrestrial environment

The overall goal of our NASA Theory Program is to study the coupling, time delays, and feedback mechanisms between the various regions of the solar-terrestrial system in a self-consistent, quantitative, manner. To accomplish this goal, it will eventually be necessary to have time-dependent macroscopic models of the different regions of the solar-terrestrial system and we are continually working toward this goal. However, our immediate emphasis is on the near-earth plasma environment, including the ionosphere, the plasmasphere, and the polar wind. In this area, we have developed unique global models that allow us to study the coupling between the different regions. These results are highlighted. Another important aspect of our NASA Theory Program concerns the effect that localized structure has on the macroscopic flow in the ionosphere, plasmasphere, thermosphere and polar wind. The localized structure can be created by structured magnetospheric inputs (i.e., structured plasma convection, particle precipitation or Birkeland current patterns) or time variations in these inputs due to storms and substorms. Also, some of the plasma flows that we predict with our macroscopic models may be unstable. Another one of our goals is to examine the stability of our predicted flows. Because time-dependent three-dimensional numerical models of the solar-terrestrial environment generally require extensive computer resources, they are usually based on relatively simple mathematical formulations (i.e., simple MHD or hydrodynamic formulations). Therefore, another long-range goal of our NASA Theory Program is to study the conditions under which various mathematical formulations can be applied to specific solar-terrestrial regions. This may involve a detailed comparison of kinetic, semikinetic, and hydrodynamic predictions for a given polar wind scenario or it may involve the comparison of a small-scale particle-in-cell (PIC) simulation of a plasma expansion event with a similar macroscopic expansion event. The different mathematical formulations have different strengths and weaknesses and a careful comparison of model predictions for similar geophysical situations will provide insight into when the various models can be used with confidence.

Schunk, Robert W.↗

The flow of plasma in the solar terrestrial environment

The overall goal of our NASA Theory Program is to study the coupling, time delays, and feedback mechanisms between the various regions of the solar-terrestrial system in a self-consistent, quantitative manner. To accomplish this goal, it will eventually be necessary to have time-dependent macroscopic models of the different regions of the solar-terrestrial system and we are continually working toward this goal. However, our immediate emphasis is on the near-earth plasma environment, including the ionosphere, the plasmasphere, and the polar wind. In this area, we have developed unique global models that allow us to study the coupling between the different regions. Another important aspect of our NASA Theory Program concerns the effect that localized structure has on the macroscopic flow in the ionosphere, plasmasphere, thermosphere, and polar wind. The localized structure can be created by structured magnetospheric inputs (i.e., structured plasma convection, particle precipitation or Birkeland current patterns) or time variations in these inputs due to storms and substorms. Also, some of the plasma flows that we predict with our macroscopic models may be unstable, and another one of our goals is to examine the stability of our predicted flows. Because time-dependent, three-dimensional numerical models of the solar-terrestrial environment generally require extensive computer resources, they are usually based on relatively simple mathematical formulations (i.e., simple MHD or hydrodynamic formulation). Therefore, another long-range goal of our NASA Theory Program is to study the conditions under which various mathematical formulations can be applied to specific solar-terrestrial regions. This may involve a detailed comparison of kinetic, semikinetic, and hydrodynamic predictions for a given polar wind scenario or it may involve the comparison of a small-scale particle-in-cell (PIC) simulation of a plasma expansion event with a similar macroscopic expansion event. The different mathematical formulations have different strengths and weaknesses and a careful comparison of model predictions for similar geophysical situations will provide insight into when the various models can be used with confidence.

Schunk, R. W.↗

The flow of plasma in the solar terrestrial environment

The overall goal of our NASA Theory Program was to study the coupling, time delays, and feedback mechanisms between the various regions of the solar-terrestrial system in a self-consistent, quantitative manner. To accomplish this goal, it will eventually be necessary to have time-dependent macroscopic models of the different regions of the solar-terrestrial system and we are continually working toward this goal. However, with the funding from this NASA program, we concentrated on the near-earth plasma environment, including the ionosphere, the plasmasphere, and the polar wind. In this area, we developed unique global models that allowed us to study the coupling between the different regions. These results are highlighted in the next section. Another important aspect of our NASA Theory Program concerned the effect that localized 'structure' had on the macroscopic flow in the ionosphere, plasmasphere, thermosphere, and polar wind. The localized structure can be created by structured magnetospheric inputs (i.e., structured plasma convection, particle precipitation or Birkland current patterns) or time variations in these input due to storms and substorms. Also, some of the plasma flows that we predicted with our macroscopic models could be unstable, and another one of our goals was to examine the stability of our predicted flows. Because time-dependent, three-dimensional numerical models of the solar-terrestrial environment generally require extensive computer resources, they are usually based on relatively simple mathematical formulations (i.e., simple MHD or hydrodynamic formulations). Therefore, another goal of our NASA Theory Program was to study the conditions under which various mathematical formulations can be applied to specific solar-terrestrial regions. This could involve a detailed comparison of kinetic, semi-kinetic, and hydrodynamic predictions for a given polar wind scenario or it could involve the comparison of a small-scale particle-in-cell (PIC) simulation of a plasma expansion event with a similar macroscopic expansion event. The different mathematical formulations have different strengths and weaknesses and a careful comparison of model predictions for similar geophysical situations provides insight into when the various models can be used with confidence.

Schunk, Robert W.↗

A critical discussion of theories of flame spread across solid and liquid fuels.

Mathematical descriptions of flames spreading over liquid and solid fuels are obtained, using basic assumptions derived from observations or physical reasoning. A review of existing theories shows that they are incomplete in that they either treat an uncoupled problem of the condensed phase where the spreading rate and heat flux at the surface are given, or they merely determine the spreading rate in terms of a new vaguely defined eigenvalue. An important difference between the liquid and solid cases, due to convection, is pointed out, and it is shown that solid-fuel flame-spread theories which claim to apply to the liquid case, in reality do not apply to it. A mathematical formulation and a method of solution are presented for the phenomenon of flame spread over solid fuels with forward heat conduction in both the solid and the gas. The method uses an energy integral over the field to determine the spreading rate in terms of the basic properties of the fuel and air.

Sirignano, W. A.↗

Bigpicc: a graph-based approach to identifying carcinogenic gene combinations from mutation data

Abstract Genome data from cancer patients represents relationships between the presence of a gene mutation and cancer occurrence in a patient. Different types of cancer in human are thought to be caused by combinations of two to nine gene mutations. Identifying these combinations through traditional exhaustive search requires the amount of computation that scales exponentially with the combination size and in most cases is intractable even for cutting-edge supercomputers. We propose a parameter-free heuristic approach that leverages the intrinsic topology of gene-patient mutations to identify carcinogenic combinations. The biological relevance of the identified combinations is measured by using them to predict the presence of tumor in previously unseen samples. The resulting classifiers for 16 cancer types perform on par with exhaustive search results, and score the average of 80.1% sensitivity and 91.6% specificity for the best choice of hit range per cancer type. Our approach is able to find higher-hit carcinogenic combinations targeting which would take years of computations using exhaustive search.

Biochemistry & Molecular Biology↗

Development of reliability prediction technique for semiconductor diodes

New fundamental technique of reliability prediction for semiconductor diodes based on realistic mathematical models can be applied to component failure rate prediction including mechanical degradation, electrical degradation, environmental stress factors, and electrical load stress factors.

Ryerson, C. M.↗

A resonant instability of model proton radiation belts in the Jovian magnetosphere

The ion cyclotron instability and characteristics of the ion cyclotron wave are discussed. A mathematical perturbation technique is applied to the dispersion relations, and the results are applied to the case of propagation parallel to the magnetic field. The ion cyclotron wave is determined in its damping and growth characteristics by resonant protons and electrons, found in momentum space on resonant surfaces. In the relativistic case the resonant surfaces are hyperbolas of revolution around the magnetic field, and protons can have a stabilizing effect. Instability rates are calculated for the region in the equatorial plane with the Ioannidis and Brice density model. The upper limit of proton flux which gives an energy density of the same order of magnitude as the magnetic field energy density is obtained. The upper limit is plotted with respect to distance from Jupiter and the minimum resonant energy contributing to the instability is also plotted.

Neubauer, F. M.↗

ACCESS 1: Approximation Concepts Code for Efficient Structural Synthesis program documentation and user's guide

The program documentation and user's guide for the ACCESS-1 computer program is presented. ACCESS-1 is a research oriented program which implements a collection of approximation concepts to achieve excellent efficiency in structural synthesis. The finite element method is used for structural analysis and general mathematical programming algorithms are applied in the design optimization procedure. Implementation of the computer program, preparation of input data and basic program structure are described, and three illustrative examples are given.

Miura, H.↗

ACCESS-2: Approximation Concepts Code for Efficient Structural Synthesis, user's guide

A user's guide is presented for the ACCESS-2 computer program. ACCESS-2 is a research oriented program which implements a collection of approximation concepts to achieve excellent efficiency in structural synthesis. The finite element method is used for structural analysis and general mathematical programming algorithms are applied in the design optimization procedure.

Miura, H.↗

Benchmark solutions for the galactic ion transport equations with spatial and energy coupling

In order to anticipate future space shielding requirements, NASA has initiated an effort to formulate computational methods to simulate radiation effects in space. As part of the program, numerical transport algorithms have been developed for the deterministic Boltzman equation describing galactic cosmic ray (GCR) interactions with matter. It thus becomes necessary to assess the accuracy of proposed deterministic algorithms. For this reason, analytical benchmark solutions to mathematically tractable galactic cosmic ray equations have recently been obtained. Even though these problems involve simplifying assumptions of the associated physics, they still contain the essential features of the basic transport processes. The solutions obtained are features of the basic transport processes. The solutions obtained are compared to results from numerical algorithms in order to ensure proper coding and to provide a measure of the accuracy of the numerical methods used in the algorithm. For the first time, mathematical methods have been applied to the galactic ion transport (GIT) equations in the straight ahead approximation with constant nuclear properties. The approach utilizes a Laplace transforms inversion yielding a closed form benchmark solution which is also computationally efficient.

Ganapol, Barry D.↗

Elementary metallography

Materials and Processes 1 (MET 141) is offered to freshmen by the Mechanical Engineering Department at Purdue University. The goal of MET 141 is to broaden the technical background of students who have not had any college science courses. Hence, applied physics, chemistry, and mathematics are included and quantitative problem solving is involved. In the elementary metallography experiment of this course, the objectives are: (1) introduce the vocabulary and establish outlook; (2) make qualitative observations and quantitative measurements; (3) demonstrate the proper use of equipment; and (4) review basic mathematics and science.

Kazem, Sayyed M.↗

Systematic Sensitivity Analysis of Metabolic Controllers During Reductions in Skeletal Muscle Blood Flow

An acute reduction in oxygen delivery to skeletal muscle is generally associated with profound derangements in substrate metabolism. Given the complexity of the human bioenergetic system and its components, it is difficult to quantify the interaction of cellular metabolic processes to maintain ATP homeostasis during stress (e.g., hypoxia, ischemia, and exercise). Of special interest is the determination of mechanisms relating tissue oxygenation to observed metabolic responses at the tissue, organ, and whole body levels and the quantification of how changes in oxygen availability affect the pathways of ATP synthesis and their regulation. In this study, we apply a previously developed mathematical model of human bioenergetics to study effects of ischemia during periods of increased ATP turnover (e.g., exercise). By using systematic sensitivity analysis the oxidative phosphorylation rate was found to be the most important rate parameter affecting lactate production during ischemia under resting conditions. Here we examine whether mild exercise under ischemic conditions alters the relative importance of pathways and parameters previously obtained.

Radhakrishnan, Krishnan↗