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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 217 records · Page 12
All sourcesNASA NTRSDOE OSTI
NASA NTRS2004

H2O2 Synthesis Induced by Irradiation of H2O with Energetic H(+) and Ar(+) Ions at Various Temperatures

The detection of H2O2 on Jupiter's icy satellite Europa by the Galileo NIMS instrument presented a strong evidence for the importance of radiation effects on icy surfaces. A few experiments have investigated whether solar flux of protons incident on Europa ice could cause a significant if any H2O2 production. These published results differ as to whether H2O2 can be formed by ions impacting water at temperatures near 80 K, which are appropriate to Europa. This discrepancy may be a result of the use of different incident ion energies, different vacuum conditions, or different ways of processing the data. The latter possibility comes about from the difficulty of identifying the 3.5 m peroxide OH band on the long wavelength wing of the much stronger water 3.1 m band. The problem is aggravated by using straight line baselines to represent the water OH band with a curvature, in the region of the peroxide band, that increases with temperature. To overcome this problem, we use polynomial baselines that provide good fits to the water band and its derivative.

Baragiola, R. A.↗
NASA NTRS1994

The use of silica aerogel to collect interplanetary dust in space

We report on impact experiments to evaluate the suitability of silica aerogel as a capture medium for interplanetary dust particles in space. The structure of silica aerogel is such that even micrometer-sized hypervelocity particles may sense it as a target of very low density; consequently shock stresses and temperatures due to impact should be minimized. We performed impact experiments in a light gas gun that employed projectiles manufactured from forsterite, pyrrhotite, and calcite. From these experiments we have developed techniques that will permit the successful extrication of interplanetary dust particles from aerogel. We note a rough correlation between increasing particle penetration lengths and decreasing aerogel density, and there is a poor correlation of track lengths with impact velocity at laboratory-attainable velocities of 5-7 km/s. We conclude that aerogel track length should not be used even as (crude) velocity indicators. Transmission electron microscope studies show the re covered particulate residues are encased in melted silica aerogel, which possibly protects the residue from some impact damage. Individual minerals within interplanetary dust are expected to exhibit differential survival, and may be vaporized, melted, dehydrated, or structurally reordered. However, some mineral grains should successfully be captured in an unmelted state at encounter velocities less than 8 km/s.

Zolensky, Michael E.↗
NASA NTRS2022

Tracking the Impacts of Precipitation Phase Changes Through the Hydrologic Cycle in Snowy Regions: From Precipitation to Reservoir Storage

Cool season precipitation plays a critical role in regional water resource management in the western United States. Throughout the twenty-first century, regional precipitation will be impacted by rising temperatures and changing circulation patterns. Changes to precipitation magnitude remain challenging to project; however, precipitation phase is largely dependent on temperature, and temperature predictions from global climate models are generally in agreement. To understand the implications of this dependence, we investigate projected patterns in changing precipitation phase for mountain areas of the western United States over the twenty-first century and how shifts from snow to rain may impact runoff. We downscale two bias-corrected global climate models for historical and end-century decades with the Weather Research and Forecasting (WRF) regional climate model to estimate precipitation phase and spatial patterns at high spatial resolution (9 km). For future decades, we use the RCP 8.5 scenario, which may be considered a very high baseline emissions scenario to quantify snow season differences over major mountain chains in the western U.S. Under this scenario, the average annual snowfall fraction over the Sierra Nevada decreases by >45% by the end of the century. In contrast, for the colder Rocky Mountains, the snowfall fraction decreases by 29%. Streamflow peaks in basins draining the Sierra Nevada are projected to arrive nearly a month earlier by the end of the century. By coupling WRF with a water resources model, we estimate that California reservoirs will shift towards earlier maximum storage by 1–2 months, suggesting that water management strategies will need to adapt to changes in streamflow magnitude and timing.

Melissa L. Wrzesien↗
NASA NTRS1978

Effect of temperature on composite sandwich structures subjected to low velocity projectile impact

An experimental investigation was conducted to study the effect of low velocity projectile impact on graphite/epoxy and Kevlar 49- graphite/epoxy sandwich structural components. Testing was performed at moderately low- and high-temperatures to assess the strength degradation of composites as compared to room temperature values. Low energy projectile impact is considered to simulate the damage caused by runway debris such as small rocks, dropping of hand tools during servicing, etc., on secondary aircraft structures fabricated out of composites. The preload and impact energy necessary to cause catastrophic failure were determined. The residual strength of impact-damaged specimens was also measured.

Sharma, A. V.↗
NASA NTRS2016

Multi-Model Assessment of Global Hydropower and Cooling Water Discharge Potential Under Climate Change

Worldwide, 98% of total electricity is currently produced by thermoelectric power and hydropower. Climate change is expected to directly impact electricity supply, in terms of both water availability for hydropower generation and cooling water usage for thermoelectric power. Improved understanding of how climate change may impact the availability and temperature of water resources is therefore of major importance. Here we use a multi-model ensemble to show the potential impacts of climate change on global hydropower and cooling water discharge potential. For the first time, combined projections of streamflow and water temperature were produced with three global hydrological models (GHMs) to account for uncertainties in the structure and parametrization of these GHMs in both water availability and water temperature. The GHMs were forced with bias-corrected output of five general circulation models (GCMs) for both the lowest and highest representative concentration pathways (RCP2.6 and RCP8.5). The ensemble projections of streamflow and water temperature were then used to quantify impacts on gross hydropower potential and cooling water discharge capacity of rivers worldwide. We show that global gross hydropower potential is expected to increase between +2.4% (GCM-GHM ensemble mean for RCP 2.6) and +6.3% (RCP 8.5) for the 2080s compared to 1971-2000. The strongest increases in hydropower potential are expected for Central Africa, India, central Asia and the northern high-latitudes, with 18-33% of the world population living in these areas by the 2080s. Global mean cooling water discharge capacity is projected to decrease by 4.5-15% (2080s). The largest reductions are found for the United States, Europe, eastern Asia, and southern parts of South America, Africa and Australia, where strong water temperature increases are projected combined with reductions in mean annual streamflow. These regions are expected to affect 11-14% (for RCP2.6 and the shared socioeconomic pathway (SSP)1, SSP2, SSP4) and 41-51% (RCP8.5-SSP3, SSP5) of the world population by the 2080s.

global hydrological models↗
NASA NTRS2011

East Asian Studies of Tropospheric Aerosols and their Impact on Regional Climate (EAST -AIRC): An overview

As the most populated region of the world, Asia is a major source of aerosols with potential large impact over vast downstream areas, Papers published in this special section describe the variety of aerosols observed in China and their effects and interactions with the regional climate as part of the East Asian Study of Tropospheric Aerosols and their Impact on Regional Climate (EAST-AIRC), The majority of the papers are based on analyses of observations made under three field projects, namely, the Atmospheric Radiation Measurements (ARM) Mobile Facility mission in China (AMF-China), the East Asian Study of Tropospheric Aerosols: An International Regional Experiment (EAST-AIRE), and the Atmospheric Aerosols of China and their Climate Effects (AACCE), The former two are U,S,-China collaborative projects, and the latter is a part of the China's National Basic Research program (or often referred to as "973 project"), Routine meteorological data of China are also employed in some studies, The wealth of general and speCIalized measurements lead to extensive and close-up investigations of the optical, physical, and chemical properties of anthropogenic, natural, and mixed aerosols; their sources, formation, and transport mechanisms; horizontal, vertical, and temporal variations; direct and indirect effects; and interactions with the East Asian monsoon system, Particular efforts are made to advance our understanding of the mixing and interaction between dust and anthropogenic pollutants during transport. Several modeling studies were carried out to simulate aerosol impact on radiation budget, temperature, precipitation, wind and atmospheric circulation, fog, etc, In addition, impacts of the Asian monsoon system on aerosol loading are also simulated.

Zhangqing, Li↗
NASA NTRS1988

Carbon dioxide catastrophes: Past and future menace

Carbon dioxide is important in its role as coupler of the terrestrial biosphere to inorganic chemical processes and as the principal greenhouse gas controlling Earth's surface temperature. The hypothesis that atmospheric CO2 levels have diminished with time, with the resulting cooling effect offsetting an increase in the solar constant, seems firmly established, and it is shown that feedback mechanisms exist which can maintain the terrestrial surface in a relatively narrow temperature range over geological time. Of the factors involved in such CO2 variation, the oceanic reservoir appears the most important. Surface waters are probably in approximate equilibrium with regard to CO2 exchange with the ambient atmosphere in most regions, but data from deep-ocean water sampling indicates that such waters are somewhat undersaturated in the sense that they would tend to absorb CO2 from the atmosphere if brought to the surface without change in composition or temperature. If major impacts into the ocean can result in loss of a substantial portion of the atmospheric CO2 reservoir, then any such future event could imperil the continuation of most higher forms of life on Earth. The most likely candidate for an inverse Nyos global event in previous Earth history is the Cretaceous-Tertiary terminal extinction event. The Cretaceous was characterized by warm, equable temperatures presumably indicative of relatively high CO2 levels and an intense greenhouse heating. Cooling of the oceans in absence of massive transfer of CO2 to the oceanic reservoir in itself would promote a condition of CO2 undersaturation in abyssal waters, and this is made even more extreme by the pattern of ocean water circulation. It is possible to envision a situation in which deep ocean waters were at least occasionally profoundly undersaturated with regard to CO2. Turnover of a major fraction of such an ocean would then remove, on a very short time scale, as much as 90 percent of the atmospheric CO2 inventory.

Baur, Mario E.↗
NASA NTRS1997

The Role of Sea Ice in 2 x CO2 Climate Model Sensitivity: Hemispheric Dependencies - Part 2

How sensitive are doubled CO2 simulations to GCM control-run sea ice thickness and extent? This issue is examined in a series of 10 control-run simulations with different sea ice and corresponding doubled CO2 simulations. Results show that with increased control-run sea ice coverage in the Southern Hemisphere, temperature sensitivity with climate change is enhanced, while there is little effect on temperature sensitivity of (reasonable) variations in control-run sea ice thickness. In the Northern Hemisphere the situation is reversed: sea ice thickness is the key parameter, while (reasonable) variations in control-run sea ice coverage are of less importance. In both cases, the quantity of sea ice that can be removed in the warmer climate is the determining factor. Overall, the Southern Hemisphere sea ice coverage change had a larger impact on global temperature, because Northern Hemisphere sea ice was sufficiently thick to limit its response to doubled CO2, and sea ice changes generally occurred at higher latitudes, reducing the sea ice-albedo feedback. In both these experiments and earlier ones in which sea ice was not allowed to change, the model displayed a sensitivity of -0.02 C global warming per percent change in Southern Hemisphere sea ice coverage.

Rind, D.↗
NASA NTRS1977

Development of Si3N4 and SiC of improved toughness

The application of energy absorbing surface layers to Si3N4 and SiC was investigated. Among the layers studied were microcracked materials such as iron titanate and a silica-zircon mixture and porous materials such as reaction sintered Si3N4. Energy absorption due to microcrack extension upon impact was found not to be an important mechanism. Instead, the fivefold improvement in Charpy and ballistic impact at elevated temperature (1250 C and 1370 C) found for Fe2TiO5 was due to plastic deformation while similar improvement found for silica-zircon mixtures at RT was due to crushing of the porous material. Due to thermal expansion mismatch, these two materials could not withstand thermal cycling when used as energy absorbing surface layers on Si3N4. Reaction sintered Si3N4 layers on dense Si3N4 were found to give up to a sevenfold increase in ballistic impact resistance due to crushing of the layer upon impact. High porosity (45%), large particle size R.S. Si3N4 layers fabricated from -100, +200 mesh Si powder gave better impact improvement than less porous (30%), small particle size layers fabricated from -325 mesh Si powder.

Brennan, J. J.↗
NASA NTRS2013

Combined Experimental and Numerical Simulations of Thermal Barrier Coated Turbine Blades Erosion

A combined experimental and computational study was conducted to investigate the erosion of thermal barrier coated (TBC) blade surfaces by alumina particles ingestion in a single stage turbine. In the experimental investigation, tests of particle surface interactions were performed in specially designed tunnels to determine the erosion rates and particle restitution characteristics under different impact conditions. The experimental results show that the erosion rates increase with increased impingement angle, impact velocity and temperature. In the computational simulations, an Euler-Lagrangian two stage approach is used in obtaining numerical solutions to the three-dimensional compressible Reynolds Averaged Navier-Stokes equations and the particles equations of motion in each blade passage reference frame. User defined functions (UDF) were developed to represent experimentally-based correlations for particle surface interaction models which were employed in the three-dimensional particle trajectory simulations to determine the particle rebound characteristics after each surface impact. The experimentally based erosion UDF model was used to predict the TBC erosion rates on the turbine blade surfaces based on the computed statistical data of the particles impact locations, velocities and angles relative to the blade surface. Computational results are presented for the predicted TBC blade erosion in a single stage commercial APU turbine, for a NASA designed automotive turbine, and for the NASA turbine scaled for modern rotorcraft operating conditions. The erosion patterns in the turbines are discussed for uniform particle ingestion and for particle ingestion concentrated in the inner and outer 5 percent of the stator blade span representing the flow cooling the combustor liner.

Hamed, Awate↗
NASA NTRS2004

A Study of the Response of Deep Tropical Clouds to Mesoscale Processes: Sensitivities to Microphysics, Radiation, and Surface Fluxes - Part 2

The Goddard Cumulus Ensemble (GCE) model is used to examine the sensitivities of surface fluxes, explicit radiation, and ice microphysical processes on multi-day simulations of deep tropical convection over the Tropical Ocean Global Atmosphere Coupled Ocean-Atmosphere Response Experiment (TOGA COARE). The simulations incorporate large-scale advective temperature and moisture forcing, as well as large-scale momentum, that are updated every time step on a periodic lateral boundary grid. This study shows that when surface fluxes are eliminated, the mean atmosphere is much cooler and drier, convection and CAPE are much weaker, precipitation is less, and cloud coverage in stratiform regions much greater. Surface fluxes using the TOGA COARE flux algorithm are weaker than with the aerodynamic formulation, but closer to the observed fluxes. In addition, similar trends noted above for the case without surface fluxes are produced for the TOGA flux case, albeit to a much lesser extent. The elimination of explicit shortwave and longwave radiation is found to have only minimal effects on the mean thermodynamics, convection, and precipitation. However explicit radiation does have a significant impact on cloud temperatures and structure above 200 mb and on the overall mean vertical circulation. The removal of ice processes produces major changes in the structure of the cloud. Much of the liquid water is transported aloft and into anvils above the melting layer (600 mb), leaving narrow, but intense bands of rainfall in convective regions. The elimination of melting processes leads to greater hydrometeor mass below the melting layer, and produces a much warmer and moister boundary layer, leading to a greater mean CAPE. Finally, the elimination of the graupel species has only a small impact on mean total precipitation, thermodynamics, and dynamics of the simulation, but does produce much greater snow mass just above the melting layer. Some of these results differ from previous CRM studies of tropical systems, which is likely due to the type of simulated system, total time integration, and model setup.

Johnson, Daniel↗
NASA NTRS1974

Strengthening silicon carbide by quenching

Quenching was used to form compressive surface layers in hot-pressed silicon carbide. The presence of the compressive stresses was verified by slotted rod tests. The slotted rod tip deflection was retained at temperatures to at least 1380 C, showing that the stresses are not relieved immediately at elevated temperatures. The flexural strength and impact resistance of specimens quenched from moderate temperatures (2000 C) were increased. Frequently, specimens quenched from higher temperatures were weakened by thermal shock damage.

Gruver, R. M.↗
NASA NTRS2019

Uncertainty of Observation Impact Estimation in an Adjoint Model Investigated with an Observing System Simulation Experiment

Adjoint models are often used to estimate the impact of different observations on short-term forecast skill. A common difficulty with the evaluation of short term forecast quality is the choice of verification fields. The use of self-analysis fields for verification is typical but incestuous, and introduces uncertainty due to biases and errors in the analysis field. In this study, an observing system simulation experiment (OSSE) is used to explore the uncertainty in adjoint model estimations of observation impact. The availability of the true state for verification in the OSSE framework in the form of the Nature Run allows calculation of the observation impact without the uncertainties present in self-analysis verification. These impact estimates are compared to estimates calculated using self-analysis verification. The Global Earth Observing System version 5 (GEOS-5) forecast model with Gridpoint Statistical Interpolation (GSI) is used with the National Aeronautics and Space Administration Global Modeling and Assimilation Office (NASA/GMAO) OSSE capability. The adjoint model includes moist processes, with total wet energy selected as the norm for evaluation of observation impacts. The results show that there are measurable but small discrepancies in the adjoint model estimation of observation impact. In general, observations of temperature and winds tend to have overestimated impacts with self-analysis verification, while observations of humidity and moisture-affected observations tend to have underestimated impacts. The small magnitude of the differences in impact estimates supports the robustness of the adjoint method of estimating observation impacts.

N C Prive↗
NASA NTRS2001

Ultrasonic Assessment of Impact-Induced Damage and Microcracking in Polymer Matrix Composites

The main objective of this NASA FAR project is to conduct ultrasonic assessment of impact-induced damage and microcracking in polymer matrix composites at various temperatures. It is believed that the proposed study of impact damage assessment on polymer matrix composites will benefit several NASA missions and current interests, such as ballistic impact testing of composite fan containment and high strain rate deformation modeling of polymer matrix composites. Impact-induced damage mechanisms in GLARE and ARALL fiber-metal laminates subject to instrumented drop-weight impacts at various temperatures were studied. GLARE and ARALL are hybrid composites made of alternating layers of aluminum and glass (for GLARE) and aramid- (for ARALL) fiber-reinforced epoxy. Damage in pure aluminum panels impacted by foreign objects was mainly characterized by large plastic deformation surrounding a deep penetration dent. On the other hand, plastic deformation in fiber-metal laminates was often not as severe although the penetration dent was still produced. The more stiff fiber-reinforced epoxy layers provided better bending rigidity; thus, enhancing impact damage tolerance. Severe cracking, however, occurred due to the use of these more brittle fiber-reinforced epoxy layers. Fracture patterns, e.g., crack length and delamination size, were greatly affected by the lay-up configuration rather than by the number of layers, which implies that thickness effect was not significant for the panels tested in this study. Immersion ultrasound techniques were then used to assess damages generated by instrumented drop-weight impacts onto these fiber-metal laminate panels as well as 6061-T6 aluminum/cast acrylic sandwich plates adhered by epoxy. Depending on several parameters, such as impact velocity, mass, temperature, laminate configuration, sandwich construction, etc., various types of impact damage were observed, including plastic deformation, radiating cracks emanating from the impact site, ring cracks surrounding the impact site, partial and full delamination, and combinations of these damages.

Liaw, Benjamin↗
NASA NTRS2007

Palomar and Table Mountain Observations of 9P/Tempel 1 during the Deep Impact Encounter: First Results

We present the first results of the Palomar Adaptive Optics observations taken during the Deep Impact encounter with 9P/Tempel 1 in July 2005. We have combined the Palomar near-IR imaging data with our visual wavelength images obtained simultaneously at JPL's Table Mountain Observatory to cover the total wavelength range from 0.4 to 2.3 micrometers in the B, V, R, I, J, H, and K filter bands, spanning the dates from 2005 July 03-07.We also include in our overall analysis images taken on the pre-encounter dates of June 1 and June 15, 2005. The broad wavelength range of our observations, along with high temporal resolution, near-IR sensitivity, and spatial resolution of our imaging, have enabled us to place constraints on the temperature of the impact flash and incandescent plume of greater than 700 K, and to provide mean dust velocities of order 197 +/- 16 m/s approximately 1.25 h after impact derived from our 1.64 micro observations. Our ejected dust mass estimates, as derived from our near-IR observations, are an order of magnitude less than those previously reported for visual wavelength observations.

Comet Tempel-1↗
NASA NTRS2017

Large Anomalies in Lower Stratospheric Water Vapor and Ice During the 2015–2016 El Niño

The strong and unusual El Niño of 2015-2016 produced a remarkable perturbation to the hydrologic budget of the tropical tropopause layer (14-19 km). This region regulates stratospheric water vapor, which has a direct radiative impact on surface temperatures. To first order, the coldest tropical tropopause temperature regulates the amount of water vapor entering the stratosphere by controlling the amount of dehydration in the rising air. Here we show that tropical convective cloud ice and associated cirrus evaporating at unusually high altitudes might also have a role in stratospheric hydration. The 2015-2016 El Niño produced decadal record water vapor amounts in the tropical Western Pacific, coincident with warm tropopause temperature anomalies. In the Central Pacific, convective cloud ice was observed 2 km above the anomalously cold tropopause. A trajectory-based dehydration model based on two reanalysis temperature and wind fields can account for only about 0.5-0.6 ppmv of the ~0.9 ppmv tropical lower stratospheric moistening observed during this event. This suggests that unresolved convective dynamics and/or associated sublimation of lofted ice particles also contributed to lower stratospheric moistening. These observations suggest that convective moistening could contribute to future climate change-induced stratospheric water vapor increases.

Atmospheric chemistry↗
NASA NTRS2010

Evaluating the Historical Importance of Impact Induced Hydrothermal Systems on Mars Using the Stable Isotopic Composition of Martian Water

The importance of impact events during the early history of Mars is obvious through a simple examination of the character of the martian surface. This ancient, heavily cratered terrain has been shown to be associated with extensive phyllosilicate deposits. This geologic link could suggest that the extensive phyllosilicate-forming alteration may have occurred during early martian history through impact-induced hydrothermal alteration. However, examination of the oxygen isotopic composition of water on Mars suggests that the extensive phyllosilicate deposits were formed primarily through low temperature (<30 C) interactions, and that high temperature weathering in impact-induced hydrothermal systems have not been a dominant process on Mars. The average oxygen isotopic composition of water on Earth is dictated by the nature of water-rock interactions. If these interactions occur at higher temperatures then the water will contain a higher proportion of 18O, while lower temperature interactions will result in water with a lower proportion of 18O. Water on Earth today contains a higher proportion of 18O because of plate tectonics and hydrothermal interaction at mid-ocean ridges. The oxygen isotopic composition of water on early earth, however, may have been quite different, containing a smaller proportion of 18O suggesting much less hydrothermal interaction. Because there are not yet any direct measurements of the oxygen isotopic composition of water on Mars, it needs to be inferred through examination of carbonates preserved in martian meteorites and the isotopic composition of atmospheric CO2. This can be done because the oxygen incorporated into carbonates and CO2 is easily exchanged with liquid water if it is present. Independently, both measurements provide an estimate for the (Sigma)18O of water on Mars to be near -16%. This composition is consistent with low temperature weathering of the silicate crust, and indicates that impact hydrothermal systems did not play an important role in the early alteration of the planet. However, our understanding of impact-induced hydrothermal systems remains unclear. If most of the water mobilized by an impact event remained at relatively low temperatures (<30deg), low-temperature interactions could predominate in these environments. These conditions would be consistent with the isotopic constraints suggested in this study.

Niles, Paul B.↗
NASA NTRS2018

Physical and Biological Properties of Cobalt- and Copper-Doped Calcium Phosphates as Bone Substitute Materials

Arthritis, osteoporosis, and other bone diseases and defects are common medical issues worldwide. By utilizing ceramic biomaterials as bone substitutes to treat these diseases, bone regeneration can be promoted and toxicity from the substitute material can be limited. Calcium phosphate (CaP) ceramics have become popular as bone substitutes due to their biocompatibility and similarity in composition to natural bone. The purpose of this research was to investigate the physical properties and biological responses of CaP-based bone substitutes, doped with metal ions. Some metal ions are present in natural bone in small amounts, and recent studies show they affect the biological responses of CaPs significantly. Dopants such as magnesium (Mg), strontium (Sr), silicon (Si) and iron (Fe) alter the phase composition, mechanical properties, osteogenesis and angiogenesis properties of CaPs, depending on their concentration and method of addition. In the present study, the effects of cobalt (Co) and copper (Cu) on the physical and biological properties of two main CaP materials, brushite cement (BrC) and tricalcium phosphate (TCP), have been investigated. Different concentrations of dopants in forms of oxide and/or chloride were selected and their effect on phase composition, sintering behavior, density, setting time, compressive strength and in vitro interaction with osteosarcoma and osteoblast cells were studied. Different techniques of sample preparation, challenges during cement preparation and compact sample pressing, sintering, and methods of dopant addition are discussed. The presence of Cu in tricalcium phosphate was found to increase thermal stability of the material and decrease the impact of sintering temperature on porosity. In addition, Cu caused a reduction in expression of inflammatory gene markers by human osteoblast cells and an increased expression at early time points due of osteoinductive markers.The addition of Cu and Co to brushite cement caused an increase in thermal stability of the material, and the addition of Cu caused significant increase in setting time. Small dopant amounts of Co caused decrease in setting time, but higher amounts caused an increase. In addition, Cu dopant in small amounts resulted in an increase of compressive strength. Both Cu and Co led to a decrease in expression of inflammatory gene markers by osteoblast and osteosarcoma cells respectively, and Cu also caused an increase in osteoinductive marker expression. Thus, these results indicate that Cu and Co have a positive impact on the physical, mechanical and biological properties of calcium phosphate biomaterials.

Cummings, Haley V.↗