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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Methylamine Separations Enabled by Cooperative Ligand Insertion in Copper–Carboxylate Metal–Organic Frameworks
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Biocatalytic Synthesis of α-Amino Esters via Nitrene C–H Insertion
α-Amino esters are precursors to noncanonical amino acids used in developing small-molecule therapeutics, biologics, and tools in chemical biology. α-C–H amination of abundant and inexpensive carboxylic acid esters through nitrene transfer presents a direct approach to α-amino esters. Methods for nitrene-mediated amination of the protic α-C–H bonds in carboxylic acid esters, however, are underdeveloped. This gap arises because hydrogen atom abstraction (HAA) of protic C–H bonds by electrophilic metal-nitrenoids is slow: metal-nitrenoids preferentially react with polarity-matched, hydridic C–H bonds, even when weaker protic C–H bonds are present. This study describes the discovery and evolution of highly stable protoglobin nitrene transferases that catalyze the enantioselective intermolecular amination of the α-C–H bonds in carboxylic acid esters. We developed a high-throughput assay to evaluate the activity and enantioselectivity of mutant enzymes together with their sequences using the Every Variant Sequencing (evSeq) method. Furthermore, the assay enabled the identification of enantiodivergent enzymes that function at ambient conditions in Escherichia coli whole cells and whose activities can be enhanced by directed evolution for the amination of a range of substrates.
Integrase-On-Demand : bioprospecting integrases for targeted genomic insertion of genetic cargo
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Evaluation of Radiation Heating and Damage for the Design of Second Target Station Monolith Inserts
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Efficient Second-Order CAD Insertion into Unstructured Meshes
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Tuning the insulator metal transition in rare earth nickelates through dynamic electrochemical ion insertion
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Project FELICIA - A probe to survey the RHIC magnet beampipe diameter for EIC beam screen insertion
The Electron Ion Collider (EIC) Hadron Storage Ring (HSR) will reuse many of the existing superconducting (SC) magnets of the RHIC storage rings. To comply with the beamline vacuum requirements in more demanding operational scenarios, the beampipe of the RHIC SC magnets will be equipped with low surface impedance, low secondary electron yield (SEY) beam screens. The installation of these beam screens will be done with the SC magnets as installed today, thus making it a critical operation for a timely EIC installation. The beam screen inner dimensions must be maximized to retain enough aperture to the beam. On the other hand, keeping enough clearance between the screen and the beampipe is critical to ensure a smooth beam screen installation. A survey probe was designed and built to measure the inner diameter of several RHIC SC magnets in-situ and provide critical data for the beam screen design optimization. This paper reports on the design of the probe and the results from the survey campaign.
Develop High-Throughput Workflows for Whole-Genome Sequencing and Insertion Site Screening (CRADA Final Report)
The engineering of microbes for biomanufacturing (e.g. of fuels, chemicals, materials) applications has advanced to a stage where researchers screen genetic libraries with millions of variations each for those with enhanced productivity. This screening, however, can be slow and expensive, as screening individual variants in a high-throughput yet cost-effective manner is challenging. In this project, we aimed to reduce by 3-fold costs associated with the sequencing aspects of the screening process (to determine which genetic variant is responsible for an observed change in productivity), while being able to process over 1,000 samples per batch.
Develop High-Throughput Workflows for Whole-Genome Sequencing and Insertion Site Screening
The engineering of microbes for biomanufacturing (e.g. of fuels, chemicals, materials) applications has advanced to a stage where researchers screen genetic libraries with millions of variations each for those with enhanced productivity. This screening, however, can be slow and expensive, as screening individual variants in a high-throughput yet cost-effective manner is challenging. In this project, we aimed to reduce by 3-fold costs associated with the sequencing aspects of the screening process (to determine which genetic variant is responsible for an observed change in productivity), while being able to process over 1,000 samples per batch.
The generation, tracking and phenotyping of a random insertional mutant library in an industrial relevant algal species, Picochlorum renovo
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Machine Tool Metrology in support of carbide insert production
In the context of lab modernization, careful consideration must be given to existing technologies, processes, and knowledge to support the ongoing production, maintenance, and improvement of products for the nuclear enterprise. This consideration often involves analyzing manufacturing processes both to pursue modernization or automation and to ensure the ability to maintain manufacturing capability.
Rotational spectral studies of O(1D) insertion reactions with methane and ethylene: Methanol and vinyl alcohol in a supersonic expansion
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V-slotted screw head and matching driving tool facilitate insertion and removal of screw fasteners
A V-slotted designed screw and a screwdriver with a V-shaped tang facilitate driving the screw into difficult locations and minimize axial forces thus avoiding damage to the screw.
Expandable insert serves as screw anchor
Expandable self-locking adapter secures components to panels having one accessible side. Mounting holes in the panels may not be threaded to accommodate screws, therefore, the adapter contains a female thread that will mate a mounting screw.
Investigation of the reliability of sterile insertion techniques for spacecraft Monthly letter report, 23 Jun. - 23 Jul. 1966
Techniques for maintaining spacecraft sterility after addition or replacement of components - microbiological contamination of sterile environments