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NASA NTRS2015

Human Research Program Advanced Exercise Concepts (AEC) Overview

Exercise countermeasures provide benefits that are crucial for successful human spaceflight, to mitigate the spaceflight physiological deconditioning which occurs during exposure to microgravity. The NASA Human Research Program (HRP) within the Human Exploration and Operations Mission Directorate (HEOMD) is managing next generation Advanced Exercise Concepts (AEC) requirements development and candidate technology maturation to Technology Readiness Level (TRL) 7 (ground prototyping and flight demonstration) for all exploration mission profiles from Multi Purpose Crew Vehicle (MPCV) Exploration Missions (up to 21 day duration) to Mars Transit (up to 1000 day duration) missions. These validated and optimized exercise countermeasures systems will be provided to the ISS Program and MPCV Program for subsequent flight development and operations. The International Space Station (ISS) currently has three major pieces of operational exercise countermeasures hardware: the Advanced Resistive Exercise Device (ARED), the second-generation (T2) treadmill, and the cycle ergometer with vibration isolation system (CEVIS). This suite of exercise countermeasures hardware serves as a benchmark and is a vast improvement over previous generations of countermeasures hardware, providing both aerobic and resistive exercise for the crew. However, vehicle and resource constraints for future exploration missions beyond low Earth orbit will require that the exercise countermeasures hardware mass, volume, and power be minimized, while preserving the current ISS capabilities or even enhancing these exercise capabilities directed at mission specific physiological functional performance and medical standards requirements. Further, mission-specific considerations such as preservation of sensorimotor function, autonomous and adaptable operation, integration with medical data systems, rehabilitation, and in-flight monitoring and feedback are being developed for integration with the exercise countermeasures systems. Numerous technologies have been considered and evaluated against HRP-approved functional device requirements for these extreme mission profiles, and include wearable sensors, exoskeletons, flywheel, pneumatic, and closed-loop microprocessor controlled motor driven systems. Each technology has unique advantages and disadvantages. The Advanced Exercise Concepts project oversees development of candidate next generation exercise countermeasures hardware, performs trade studies of current and state of the art exercise technologies, manages and supports candidate systems physiological evaluations with human test subjects on the ground, in flight analogs and flight. The near term goal is evaluation of candidate systems in flight, culminating in an integrated candidate next generation exercise countermeasures suite on the ISS which coalesces research findings from HRP disciplines in the areas of exercise performance for muscle, bone, cardiovascular, sensorimotor, behavioral health, and nutrition for optimal benefit to the crew.

Countermeasures↗

NASA NTRSDate not supplied

Developing Mission Segment-Specific Clinical Data for Impact

Space exploration missions represent a significant future objective for NASA’s human spaceflight operations for the near and long term. By operating missions during longer periods and over further distances, NASA’s mission planning models, hardware systems, and medical capabilities will be stretched beyond their original design constraints. The necessity of medical training and medical supply manifesting for such missions is likely to become incredibly intricate as trade-space analysis is performed over varying mission profiles. For this purpose, IMPACT was created to extend and improve the Integrated Medical Model (IMM) which is used for International Space Station (ISS) medical predications and consists of a probabilistic risk assessment tool that simulates missions to calculate risks given the constraints on crew complement, mission duration and activity (such as Extravehicular Activities), power, communication, mass, volume, and evacuation consideration as well as to predict mission outcomes. Currently, the medical evidence used to support IMPACT remains static, addressing risks of a medical condition and the impacts of the condition during spaceflight only, but is only calculated for a small number of mission parameters. Extended missions will consist of new and varied living environments, changing gravitational loads, and dynamic working requirements. Medical risks are not typically constant but will change depending upon the physical and physiological environment of the body during all phases of a mission. Risks are likely to shift during different mission segments, and understanding how components of a mission profile change risks will assist mission planners to increase chances for mission success.

Christopher Zahner↗

NASA NTRSDate not supplied

Derivation of the Most Influential Medical Conditions for An Extended Duration Artemis Mission

BACKGROUND: The risk of loss of mission due to medical conditions may be influenced by loss of crew life (LOCL), need for evacuation (RTDC; return to definitive care), and crew task time lost. Predicting what medical conditions are most likely to lead to crew morbidity and mortality may influence medical system design, clinical capability prioritization, and research strategies. NASA’s Informing Mission Planning via Analysis of Complex Tradespaces tool (IMPACT) applies Probabilistic Risk Assessment (PRA) methodology to assess these risks. OVERVIEW: A team of subject matter experts (SME) from a variety of medical disciplines developed a consensus-based process to determine 120 of the most clinically relevant medical conditions for long-duration exploration missions (LDEMs) . This IMPACT Condition List (ICL) expanded upon previous work done for Integrated Medical Model (IMM). For each condition a best-case and worst-case definition were derived. These definitions were used to identify probability of occurrence, proportion of cases that are best case vs. worst case, clinical phase duration, and risk of outcomes (task time loss [TTL], RTDC, and LOCL) for both treated and untreated states. These data were sources from existing spaceflight databases (e.g. Longitudinal Survey of Astronaut Health), relevant models (e.g. the ISS fire model), and/or terrestrial literature. Each condition was then tied to diagnostic and therapeutic resources and capabilities. IMPACT was then run for the LDLOLS DRM (see Abstract #2 for this panel). DISCUSSION: This abstract will present the process for generating the IMPACT condition list, the relevant data for each clinical condition, and present results for the ten most influential conditions impacting LOCL, RTDC, and TTL for a representative extended duration Artemis mission.

A Nelson↗

NASA NTRS2024

Alignment of NASA’s Human System Risks with Technological Capability Gaps to Enable Integrated Research and Technology Development Strategic Planning

BACKGROUND: Radiation, reduced gravity, distance from earth, isolation and confinement, and habitation within artificially created and controlled life support environments are hazards that present risk to human space explorers. NASA’s Human System Risk Board (HSRB) maintains a set of twenty-nine different Human System Risks with subject matter experts from across the agency providing regular updates to the estimated likelihood and consequence associated with each risk. The Human Research Program (HRP) has historically used these risk classifications as a primary basis for identifying and prioritizing human research investments aimed at characterizing and/or mitigating the respective human system risks. In many cases, technology development is required to mature and validate risk mitigation strategies, however, NASA’s primary technology development programs have not typically used Human System Risks as a basis for strategic planning. A primary function of the Environmental Control and Life Support Systems (ECLSS) – Crew Health and Performance (CHP) System Capability Leadership Team (SCLT) is to continually identify, review, and update technological capability gaps and to establish and oversee multiyear strategic roadmaps aimed at guiding NASA’s technology development priorities in these areas. These roadmaps are intended to be agency-wide and independent of any program, directorate, or other organization within NASA. DESCRIPTION: The SCLT and HRP collaborated to establish a set of Human System Capability Gaps, which establish a formal linkage between the capability gaps used to prioritize investments across much of NASA, and the Human System Risks that are primarily used to inform and prioritize human research. This set of twenty-eight gaps was developed by subject matter experts, and each gap mapped to the primary associated Human System Risks. The gaps and risk mapping were then reviewed and approved via the HSRB, thereby formally aligning the research-focused Human System Risks with the technology-focused capability gaps. DISCUSSION: This effort has enabled development of integrated roadmaps and budget coordination with research and technology development activities that are formally linked to agency-recognized capability gaps and Human System Risks. Close and ongoing coordination between the SCLT, HRP, Mars Campaign Office, and the Health & Medical Technical Authority (HMTA) is essential to ensure alignment and prioritization of CHP-related research and technology development to enable NASA’s future exploration missions.

Andrew F J Abercromby↗

NASA NTRS2015

Integrated Medical Model Overview

The Integrated Medical Model (IMM) Project represents one aspect of NASA's Human Research Program (HRP) to quantitatively assess medical risks to astronauts for existing operational missions as well as missions associated with future exploration and commercial space flight ventures. The IMM takes a probabilistic approach to assessing the likelihood and specific outcomes of one hundred medical conditions within the envelope of accepted space flight standards of care over a selectable range of mission capabilities. A specially developed Integrated Medical Evidence Database (iMED) maintains evidence-based, organizational knowledge across a variety of data sources. Since becoming operational in 2011, version 3.0 of the IMM, the supporting iMED, and the expertise of the IMM project team have contributed to a wide range of decision and informational processes for the space medical and human research community. This presentation provides an overview of the IMM conceptual architecture and range of application through examples of actual space flight community questions posed to the IMM project.

Spae Adaptation Syndrome↗

NASA NTRS2010

Human Health and Performance Considerations for Exploration of Near-Earth Asteroids

This presentation will describe the human health and performance issues that are anticipated for the human exploration of near-Earth asteroids (NEA). Humans are considered a system in the design of any such deep-space exploration mission, and exploration of NEA presents unique challenges for the human system. Key factors that define the mission are those that are strongly affected by distance and duration. The most critical of these is deep-space radiation exposure without even the temporary shielding of a nearby large planetary body. The current space radiation permissible exposure limits (PEL) restrict mission duration to 3-10 months depending on age and gender of crewmembers and stage of the solar cycle. Factors that affect mission architecture include medical capability; countermeasures for bone, muscle, and cardiovascular atrophy during continuous weightlessness; restricted food supplies; and limited habitable volume. The design of a habitat that can maintain the physical and psychological health of the crew and support mission operations with limited intervention from Earth will require an integrated research and development effort by NASA s Human Research Program, engineering, and human factors groups. Limited abort and return options for an NEA mission are anticipated to have important effects on crew psychology as well as influence medical supplies and training requirements of the crew. Other important factors are those related to isolation, confinement, communication delays, autonomous operations, task design, small crew size, and even the unchanging view outside the windows for most of the mission. Geological properties of the NEA will influence design of sample handling and containment, and extravehicular activity capabilities including suit ports and tools. A robotic precursor mission that collects basic information on NEA surface properties would reduce uncertainty about these aspects of the mission as well as aid in design of mission architecture and exploration tasks.

Kundrot, Craig↗

NASA NTRS2007

Zero-Gravity Locomotion Simulators: New Ground-Based Analogs for Microgravity Exercise Simulation

Maintaining health and fitness in crewmembers during space missions is essential for preserving performance for mission-critical tasks. NASA's Exercise Countermeasures Project (ECP) provides space exploration exercise hardware and monitoring requirements that lead to devices that are reliable, meet medical, vehicle, and habitat constraints, and use minimal vehicle and crew resources. ECP will also develop and validate efficient exercise prescriptions that minimize daily time needed for completion of exercise yet maximize performance for mission activities. In meeting these mission goals, NASA Glenn Research Center (Cleveland, OH, USA), in collaboration with the Cleveland Clinic (Cleveland, Ohio, USA), has developed a suite of zero-gravity locomotion simulators and associated technologies to address the need for ground-based test analog capability for simulating in-flight (microgravity) and surface (partial-gravity) exercise to advance the health and safety of astronaut crews and the next generation of space explorers. Various research areas can be explored. These include improving crew comfort during exercise, and understanding joint kinematics and muscle activation pattern differences relative to external loading mechanisms. In addition, exercise protocol and hardware optimization can be investigated, along with characterizing system dynamic response and the physiological demand associated with advanced exercise device concepts and performance of critical mission tasks for Exploration class missions. Three zero-gravity locomotion simulators are currently in use and the research focus for each will be presented. All of the devices are based on a supine subject suspension system, which simulates a reduced gravity environment by completely or partially offloading the weight of the exercising test subject s body. A platform for mounting treadmill is positioned perpendicularly to the test subject. The Cleveland Clinic Zero-g Locomotion Simulator (ZLS) utilizes a pneumatic subject load device to apply a near constant gravity-replacement load to the test subject during exercise, and is currently used in conjunction with the General Clinical Research Center for evaluating exercise protocols using a bedrest analog. The enhanced ZLS (eZLS) at NASA Glenn Research Center features an offloaded treadmill that floats on a thin film of air and interfaces to a force reaction frame via variably-compliant isolators, or vibration isolation system. The isolators can be configured to simulate compliant interfaces to the vehicle, which affects mechanical loading to crewmembers during exercise, and has been used to validate system dynamic models for new countermeasures equipment designs, such as the second International Space Station treadmill slated for use in 2010. In the eZLS, the test subject and exercise device can be pitched at the appropriate angle for partial gravity simulations, such as lunar gravity (1/6th earth gravity). On both the eZLS and the NASA-Johnson Space Center standalone ZLS installed at the University of Texas Medical Branch in Galveston, Texas, USA, the subject's body weight relative to the treadmill is controlled via a linear motor subject load device (LM-SLD). The LM-SLD employs a force-feedback closed-loop control system to provide a relatively constant force to the test subject during locomotion, and is set and verified for subject safety prior to each session. Locomotion data were collected during parabolic flight and on the eZLS. The purpose was to determine the similarities and differences between locomotion in actual and simulated microgravity. Subjects attained greater amounts of hip flexion during walking and running during parabolic flight. During running, subjects had greater hip range of motion. Trunk motion was significantly less on the eZLS than during parabolic flight. Peak impact forces, loading rate, and impulse were greater on the eZLS than during parabolic while walking with a low external load (EL) and rning with a high EL. Activation timing differences existed between locations in all muscles except for the rectus femoris. The tibialis anterior and gluteus maximus were active for longer durations on the eZLS than in parabolic flight during walking. Ground reaction forces were greater with the LM-SLD than with bungees during eZLS locomotion. While the eZLS serves as a ground-based analog, researchers should be aware that subtle, but measurable, differences in kinematics and leg musculature activities exist between the environments. Aside from space applications, zero-gravity locomotion simulators may help medical researchers in the future with development of rehabilitative or therapeutic protocols for injured or ill patients. Zero-gravity locomotion simulators may be used as a ground-based test bed to support future missions for space exploration, and eventually may be used to simulate planetary locomotion in partial gravity environments, including the Moon and Mars. Figure: Zero-gravity Locomotion Simulator at the Cleveland Clinic, Cleveland, Ohio, USA

Perusek, Gail P.↗

NASA NTRSDate not supplied

Crew Health and Performance Integrated Data System Platform Project Updates

Future human exploration missions introduce a new paradigm as crews move further from the resupply and near real-time ground support typical of Low Earth Orbit missions today. Without immediate support from ground-based personnel, exploration crews will be more reliant on inflight data and technology to respond to emergencies and anomalies. Today, in-flight data is often siloed, unsynchronized, and largely inaccessible in real time. Many data sets require manual entry and/or data transfer between vehicles and the ground. These issues contribute to risks in supporting crew autonomy for future exploration missions. An integrated data system platform is needed to mitigate these risks by supporting a new generation of technologies and employing advanced analytical and predictive modeling techniques to enable crew autonomy for future exploration missions. The Crew Health and Performance Integrated Data System Platform (CHP-IDSP) project is laying a foundation for future in-flight informatics by providing a back-end architecture for collecting, storing, and integrating multiple sources of data generated by and around the crew. This cohesive integration point will streamline the management of CHP data (e.g., environmental, exercise, medical, sleep, performance, etc.) and facilitate situation awareness and decision support required by the crew and remote support of exploration missions. This presentation will describe the ongoing development effort of the path-to-flight CHP-IDSP software and the demonstration of its core capabilities. This includes a brief history of the project, the human-centered process used to identify data needs and workflows feeding the development of scenarios and requirements, and current subsystem development status. Current integrations, including the Chiron exploration electronic health record application, will be discussed. Future work includes collaboration with additional CHP domains and a flight technology demonstration.

Data integration↗

NASA NTRSDate not supplied

Crew Health and Performance Integrated Data Service Platform (CHP-IDSP): Project Updates

Future human exploration missions introduce a new paradigm as crews move further from the resupply and near real-time ground support typical of Low Earth Orbit missions today. Without immediate support from ground-based personnel, exploration crews will be more reliant on inflight data and technology to respond to emergencies and anomalies. Today, in-flight data is often siloed, unsynchronized, and largely inaccessible in real time. Many data sets require manual entry and/or data transfer between vehicles and the ground. These issues contribute to risks in supporting crew autonomy for future exploration missions. An integrated data services platform is needed to mitigate these risks by supporting a new generation of technologies and employing advanced analytical and predictive modeling techniques to enable crew autonomy for future exploration missions. The Crew Health and Performance Integrated Data System Platform (CHP-IDSP) project is laying a foundation for future in-flight informatics by providing a back-end architecture for collecting, storing, and integrating multiple sources of data generated by and around the crew. This cohesive integration point will streamline the management of CHP data (e.g., environmental, exercise, medical, sleep, performance, etc.) and facilitate situation awareness and decision support required by the crew and remote support of exploration missions. This presentation will describe the ongoing development effort of the path-to-flight CHP-IDSP software and the demonstration of its core capabilities. This includes a brief history of the project, the human-centered process used to identify data needs and workflows feeding the development of scenarios and requirements, and current subsystem development status. Current integrations, including the Chiron exploration electronic health record application, will be discussed. Future work includes collaboration with additional CHP domains and a flight technology demonstration.

Software↗

NASA NTRS2016

Surgical Capabilities for Exploration and Colonization Space Flight - An Exploration Symposium

Surgical capabilities in human space flight, whether on a space-based platform in low Earth orbit or on a long duration planetary exploration mission, will be challenging to conduct for a variety of reasons, some of which will be ameliorated by training, technology, and pre-flight planning. Nevertheless, inherent risks and challenges remain. Early space missions did not have any surgical capability. It was not until NASA's Skylab mission that serious consideration was given to this fundamental medical care capability. Over the past 30 years, subject matter experts have been brought together for discussion on the myriad of challenges and opportunities in this endeavor. The last such meeting was held in 2005 at the NASA Johnson Space Center. As we continue to move forward with human space flight activities for the International Space Station and beyond, the capabilities of information technology, robotics, sensors and imaging have rapidly changed since the last gathering of expertise. In December 2015, through sponsorship of the National Space Biomedical Research Institute (NSBRI), a diverse group of individuals from government, academia, and industry representing three countries gathered at the NSBRI Space 4 Biomedicine facility in Houston, TX. This two day symposia included comprehensive sessions that addressed the challenges that we all face in developing, deploying, and utilizing surgical care capabilities in all human space missions, regardless of mission duration or profile. The symposium benefited from the knowledge and experience of three seasoned NASA physician astronauts, Drs. Jay Buckey, Thomas Marshburn, and Lee Morin. At the end of the first day, the assembled group heard from the crew members about their experiences and their ideas. It is clear that the discussion of surgical capabilities is part of the larger discussion of consideration of advanced healthcare, including critical care, on exploration space missions. This report represents the culmination of the symposium, capturing knowledge, experience, conceptual dialogue, and a narrative that can be used in supporting the development of future programs and potential policy. Each of the presentations that were provided by the guest speakers is included in the appendices. Those presentations that are not included were due to sensitivity of the material or at the request of the speaker. In addition, each speaker was offered an opportunity to provide comments in a 'lightning round' format. All of these comments and speaker abstracts also appear in the appendices. At the conclusion of the second day, a discussion was held that reviewed the priorities that perhaps add value to decision makers. These are also summarized. This report will serve as the final product of this symposium. Additional material may be produced for the peer-reviewed literature.

Doarn, Charles R.↗

NASA NTRS2009

Results From the John Glenn Biomedical Engineering Consortium. A Success Story for NASA and Northeast Ohio

The John Glenn Biomedical Engineering Consortium was established by NASA in 2002 to formulate and implement an integrated, interdisciplinary research program to address risks faced by astronauts during long-duration space missions. The consortium is comprised of a preeminent team of Northeast Ohio institutions that include Case Western Reserve University, the Cleveland Clinic, University Hospitals Case Medical Center, The National Center for Space Exploration Research, and the NASA Glenn Research Center. The John Glenn Biomedical Engineering Consortium research is focused on fluid physics and sensor technology that addresses the critical risks to crew health, safety, and performance. Effectively utilizing the unique skills, capabilities and facilities of the consortium members is also of prime importance. Research efforts were initiated with a general call for proposals to the consortium members. The top proposals were selected for funding through a rigorous, peer review process. The review included participation from NASA's Johnson Space Center, which has programmatic responsibility for NASA's Human Research Program. The projects range in scope from delivery of prototype hardware to applied research that enables future development of advanced technology devices. All of the projects selected for funding have been completed and the results are summarized. Because of the success of the consortium, the member institutions have extended the original agreement to continue this highly effective research collaboration through 2011.

Nall, Marsha M.↗

NASA NTRS2024

NASA’s Top Human System Research and Technology Needs for Mars

NASA is working with industry and international partners to return humans to the Moon and to eventually enable humans to explore Mars. Within NASA, several organizations work together to identify, prioritize, fund, execute, and operationalize the research and technology development (R&TD) that will be necessary to enable crew health and performance (CHP) during these future missions. These organizations include flight programs, the Health and Medical Technical Authority (HMTA), the Human Research Program, the Space Technology Mission Directorate, System Capability Leadership Teams, and other organizations, many of which existed for several years prior to the creation of the Moon-to-Mars (M2M) Program Office in 2023. A variety of constructs, vocabularies, and processes exist for managing risks and supporting strategic planning across these organizations. For example, M2M objectives, program risks, human system risks, human research gaps, capability gaps, and envisioned futures are all constructs currently used within NASA to identify and prioritize R&TD needs. These strategic planning constructs are evolving to allow M2M objectives and R&TD investments to be aligned and traced at a detailed level. A recognized need exists among stakeholder organizations to identify and communicate the highest CHP R&TD priorities in a unified and digestible way that addresses the perspectives of NASA’s CHP community. To achieve this, the HMTA arranged a series of discussions with representatives of NASA’s CHP community, during which the 8 highest priority CHP capabilities that will enable human missions to Mars, referred to as the “top human system capability needs for Mars”, were identified. The list includes Earth-independent human operations; Mars-duration food system; Mars-duration effects on human physiology; risk mitigations for vehicle atmospheres; computational injury and anthropometric models; exploration exercise countermeasures; individual variability in responses to spaceflight; and sensorimotor countermeasures. Existing tools and processes for strategic planning and risk management were evaluated, as well as the technical practicalities, cost, and schedule feasibility associated with potential R&TD investments in different capability need areas. This capability needs report is not owned by any one NASA organization and does not replace existing strategic or program planning processes; rather it aims to complement and inform them with a unified set of community generated priorities. These top capability needs will be re-evaluated periodically based on R&TD progress and the evolving M2M architecture.

technology gaps↗

NASA NTRSDate not supplied

NASA’s Top Human System Research and Technology Needs for Mars

technology gaps↗

NASA NTRS1985

Tradeoff analysis of technology needs for public service helicopters

The design requirements for a family or type of Public Service Helicopter (PSH) is examined which will satisfy the needs of municipal and state governments in the following mission areas: Emergency Medical Service--Airborne Rescue Squad; Law Enforcement; Search and Rescue; and Environmental Control (Fire Fighting, Pollution, Resource Management). The report compares both design and performance requirements as specified by the PSH user's group against current technological capabilities, RTOPS and US Army LHX design requirements. The study explores various design trade-offs and options available to the aircraft designer/manufacturer in order to meet the several criteria specified by the PSH user's group. In addition, the report includes a brief assessment of the feasibility of employing certain advanced rotorcraft designs to meet the stringent combination of operational capabilities desired by the Public Service Helicopter Users.

Bauchspies, J. S.↗

NASA NTRSDate not supplied

Crew Medical Training to Progressively Enable EIMO

Background. Onboard medical capabilities have greatly expanded over the history of the US space program. Newly identified space-related medical conditions, technological advances, and longer mission durations have led to an increasing need for on-demand medical expertise. Lengthy communications delays, lack of resupply and evacuation opportunities on exploration-class missions place an ever-increasing burden on the crew to provide medical care. Having adequate knowledge, skills, and abilities (KSA) available is an essential component of successful Earth Independent Medical Operations (EIMO). Without appropriate crew training and KSA, cutting-edge medical equipment has little value. Presumably, the crew will include a qualified physician; however, if the physician is incapacitated, a non-physician crew medical officer (CMO) will be needed. While more crew time is needed for medical training, there will be concomitant increases in preflight training demands for vehicle system management, operations, science, and contingencies. In truly independent operations, onboard resources such as just-in-time training, mixed reality, decision support tools, and AI-enabled chatbot “consultants” will be needed to augment KSA. Overview. Because of crew time constraints, topical priorities must be determined for preflight training. Curricula should be developed that emphasize management of conditions with relatively high incidence and morbidity/mortality. Defining the required KSA levels to treat each condition is essential, but all crewmembers should have basic lifesaving skills. Procedural and diagnostic training on live patients and simulators should be prioritized over classroom lectures. Crews must be trained with onboard equipment, resources, mixed reality, and AI-based decision support tools. Mission simulations should include medical problems with/without ground support and with appropriate communication delays. Certification guidelines for each level of KSA must be established. Skills rapidly decay for non-physician CMO’s; both pre-flight and in-flight refresher training will be needed. During spaceflight just-in-time training, simulations, and onboard CME with crew physician can help retain skills. Discussion. Medical technology, simulation design, mixed reality, and AI are advancing at a dizzying rate. Recognizing the severe constraints on crew time, it is critical that astronaut training is highly efficient and adapted to keep pace with new innovations both pre-flight and during exploration missions. These challenges will be discussed during this panel session.

Jay Lemery↗

NASA NTRSDate not supplied

IMPACT 1.0—Task Impairment: A Novel Approach for Assessing Impairment during Exploration-Class Missions

Exploration-class and International Space Station (ISS) missions have significantly different levels of associated medical risk for crewmembers. The Integrated Medical Model (IMM), the probabilistic risk assessment tool used for ISS medical trade-space analyses, uses a Functional Impairment (FI) metric to determine quality time lost should a crewmember be afflicted with a medical condition. While IMM-based FI has been successful for ISS operations, it has limitations when applied to exploration-class missions. As the National Aeronautics and Space Administration (NASA) looks ahead to Gateway, Artemis, and Martian missions, a novel, dynamic, and mission-appropriate impairment paradigm is necessary for accurate contingency planning. This paradigm, Task Impairment (TI), fulfills that need by utilizing mission-specific tasks. TI will allow future capability for a loss of mission metric, previously not available with IMM. TI serves as a replacement metric for FI within IMPACT, the next-generation trade-space analysis tool suite created to replace the IMM. IMPACT significantly increases the fidelity of probabilistic risk assessment for exploration-class missions. The Human Exploration of Mars Preliminary List of Crew Tasks (MTL, a source of 1100+ exploration-class mission-specific tasks for crewmembers) was used to calculate TI. Using the Task List, 18 individual Human System Categories were identified as being required to perform each task (e.g., Cardiopulmonary, Cognitive, etc.). Each of the 1200+ tasks were mapped to the Human System categories listed in the Task List. The total number of tasks in each category were tallied to determine how many tasks required each Human System. Lastly, each of the 120 medical conditions from the IMPACT condition list were mapped to the Human System categories to complete the TI calculation. NASA subject matter experts across five medical specialties established consensus for the mapping of each condition. The resulting total tasks impaired by each condition were used to calculate discrete TI values. This process was repeated for each of the four severity/resource utilization variants of each condition, and for each of the three phases of clinical care. Through this process, discrete TI values were calculated for each of the 120 IMPACT medical conditions and their variants. The Task Impairment metric provides higher fidelity, dynamic utility, and quicker analysis of medical impairment compared to the previous Functional Impairment metric used for the Integrated Medical Model. TI will be used for higher fidelity medical impairment analysis and contingency planning during Lunar, Martian, and other long-term exploration-class missions.

William L Fernandez↗

NASA NTRSDate not supplied

NASA's Habitation Development Status: Current Concepts and ISRU Opportunities

Introduction: The National Aeronautics and Space Administration (NASA) is embarking on a bold journey to return humankind to the Moon and onward to Mars with innovative commercial, international, and academic partnerships. Under the Artemis series of missions, NASA seeks to establish sustained human exploration of deep space through an objectives-based approach. This approach drives the identification of needed system functionality and the current and future capabilities which will eventually allow humanity to sustainably live beyond Earth. Providing evolvable and scalable habitation is a cornerstone function that calls for the collection and integration of current, developmental, and future technologies that can meet near-term exploration needs while growing into long-term sustained presence. NASA is advancing in-space habitation through its Next Space Technologies for Exploration Partnerships (NextSTEP) model while designing lunar, Mars transit, and Mars surface habitat government reference concepts for Artemis missions. These efforts have unveiled possible near-term opportunities for the in-space resource utilization community if human habitation is considered a future customer of space resources. NextSTEP Habitation Development: NASA is closely working with commercial partners under its NextSTEP Appendix A model to advance habitation systems in the arena of inflatable and composite habitation structures. Such efforts promise efficiencies in volumetric packaging and overall spacecraft mass respectively. Recent testing by commercial partners have helped to quantify possible failure mechanisms for inflatable structures while advancing their technology towards eventual flight certification. The advancement of such Class II habitation structures, in which the habitat is only fully deployed once in-space or on a planetary surface, is critical to providing increased habitable volume for long-duration missions with no additional mass penalties. The progression of such technology is infused into NASA’s government reference concepts for notional deep space habitation concepts. Current Government Reference Concepts: To best inform the formulation of future collaborative solicitations, NASA employs the practice of internally developing reference concepts for future exploration elements. These concepts aid in identifying the functions and capabilities needed to complete NASA missions as well as feasible solutions within the timeframe needed. Government reference concepts for a lunar Surface Habitat, Mars Transit Habitat, and Mars Sur-face Habitat are continuously being developed and updated to better guide the Agency’s overall exploration architecture. Lunar Surface Habitat. As NASA returns to the Moon, it is evaluating possible lunar surface habitation concepts. The Surface Habitat (SH) reference concept entails a hybrid metallic-inflatable structure capable of initially housing two crew for surface stays of up to 30 days in duration. While initial missions may span ~7 days in duration, consideration is being given to expanding SH’s capability to support a crew of four for up to 60 days over its 15-year design life. Functionally, the SH serves as a ‘hub’ for all Artemis crewed surface operations, providing internal volume for maintenance, medical, logistics, science utilization, and extravehicular activity (EVA) support in addition to core habitation functionality such as environmental control and life support (ECLS) and power generation and distribution among many others. Additionally, NASA has entered a study agreement with the Italian Space Agency (Agenzia Spaziale Italiana – ASI) to investigation a possible Multi-Purpose Habitat (MPH) as an additional or augmenting habit-able element for the lunar surface. Mars Transit Habitat. NASA’s current architectural concept for initial human missions to Mars entails the utilization of a transit habitat (TH) to transport a four-person crew to and from Mars orbit, departing from and returning to a lunar near-rectilinear halo orbit (NRHO), over the course of a ~1,200-day mission. While holding a similar 15-year design lifetime, TH will also support a series of analog mission activities in NRHO to gradually test the systems and interaction with lunar surface elements, some of which may be adapted for Mars surface exploration. Holding similar functional capabilities as SH, TH is sized to support much longer durations in space and greater logistical independence. Mars Surface Habitat. NASA is still exploring the concept of operations for initial crewed missions to Mars. As such, the Mars Surface Habitat (MSH) concept is still in its infancy as options for mobile, pressurized habitation and stationary habitats are being explored. It is expected MSH will leverage heavily from the lunar SH and possible lunar pressurized rover, however the very different Martian environment will likely necessitate modifications. ISRU Opportunities: Despite the advancements under NASA’s NextSTEP habitation work and continually optimized reference concepts, NASA is facing near-term mass and power challenges that may create opportunities to the ISRU community by providing yet another possible customer for space resources. While NASA desires to use regenerative ECLS systems (ECLSS) for all habitation concepts, their operation comes with initial mass penalties and maintenance overheads when compared to simpler open-loop architectures. Because of this, NASA is currently pro-posing an open-loop, consumables-based architecture for its surface habitats to achieve initial launch and delivery lander mass targets while scarring for the in-corporation of regenerative ECLSS to meet longer mission durations and sustained presence. With such an architecture, oxygen and potable water are needed consumables, which initial ISRU systems may be able to provide in a pilot capacity. Although the TH is expecting to utilize regenerative ECLSS, advancements in lunar surface-based ISRU and possible re-supply of spacecraft in lunar or Mars orbit could significantly reduce the logistical need for ECLSS related spares on TH and possibly allow a similar open-loop and consumables-based architecture. In addition to ECLSS mass concerns, the SH is facing challenges with energy storage to support operations over periods of darkness exceeding 100 hours. Both battery and fuel cell-based power architectures are being traded, opening options for external power generation and energy storage. One possibility is ISRU-produced H2 and O2 feeding external primary fuel cell systems which could supplement habitation power generation while reducing initial mass and volume until much more powerful fission power systems might be deployed. Conclusion: Significant advancements are being made in evolvable habitation concepts that span from near-term technologies, such as inflatable structures under NextSTEP, to potentially revolutionary capabilities like the lunar surface construction as funded through the Moon-to-Mars Planetary Autonomous Construction Technologies (MMPACT) project. As NASA investigates both heritage capabilities and rap-idly advancing, disruptive technologies, there are likely many near-term opportunities for initial ISRU capabilities to significantly aid human habitation and increase self-sufficiency beyond Earth.

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NASA's Habitation Development Status: Current Concepts and ISRU Opportunities

Introduction: The National Aeronautics and Space Administration (NASA) is embarking on a bold journey to return humankind to the Moon and onward to Mars with innovative commercial, international, and academic partnerships [1]. Under the Artemis series of missions, NASA seeks to establish sustained human exploration of deep space through an objectives-based approach [2]. This approach drives the identification of needed system functionality and the current and future capabilities which will eventually allow humanity to sustainably live beyond Earth. Providing evolvable and scalable habitation is a cornerstone function that calls for the collection and integration of current, developmental, and future technologies that can meet near-term exploration needs while growing into long-term sustained presence. NASA is advancing in-space habitation through its Next Space Technologies for Exploration Partnerships (NextSTEP) model while designing lunar, Mars transit, and Mars surface habitat government reference concepts for Artemis missions. These efforts have unveiled possible near-term opportunities for the in-space resource utilization community if human habitation is considered a future customer of space resources. NextSTEP Habitation Development: NASA is closely working with commercial partners under its NextSTEP Appendix A model to advance habitation systems in the arena of inflatable and composite habitation structures. Such efforts promise efficiencies in volumetric packaging and overall spacecraft mass respectively. Recent testing by commercial partners have helped to quantify possible failure mechanisms for inflatable structures while advancing their technology towards eventual flight certification. The advancement of such Class II habitation structures, in which the habitat is only fully deployed once in-space or on a planetary surface [3], is critical to providing increased habitable volume for long-duration missions with no additional mass penalties. The progression of such technology is infused into NASA’s government reference concepts for notional deep space habitation concepts. Current Government Reference Concepts: To best inform the formulation of future collaborative solicitations, NASA employs the practice of internally developing reference concepts for future exploration elements. These concepts aid in identifying the functions and capabilities needed to complete NASA missions as well as feasible solutions within the timeframe needed. Government reference concepts for a lunar Surface Habitat, Mars Transit Habitat, and Mars Sur-face Habitat are continuously being developed and updated to better guide the Agency’s overall exploration architecture. Lunar Surface Habitat. As NASA returns to the Moon, it is evaluating possible lunar surface habitation concepts. The Surface Habitat (SH) reference concept entails a hybrid metallic-inflatable structure capable of initially housing two crew for surface stays of up to 30 days in duration [4]. While initial missions may span ~7 days in duration, consideration is being given to expanding SH’s capability to support a crew of four for up to 60 days over its 15-year design life [5]. Functionally, the SH serves as a ‘hub’ for all Artemis crewed surface operations, providing internal volume for maintenance, medical, logistics, science utilization, and extravehicular activity (EVA) support in addition to core habitation functionality such as environmental control and life support (ECLS) and power generation and distribution among many others. Additionally, NASA has entered a study agreement with the Italian Space Agency (Agenzia Spaziale Italiana – ASI) to investigation a possible Multi-Purpose Habitat (MPH) as an additional or augmenting habit-able element for the lunar surface [6]. Mars Transit Habitat. NASA’s current architectural concept for initial human missions to Mars entails the utilization of a transit habitat (TH) to transport a four-person crew to and from Mars orbit, departing from and returning to a lunar near-rectilinear halo orbit (NRHO), over the course of a ~1,200-day mission [5]. While holding a similar 15-year design lifetime, TH will also support a series of analog mission activities in NRHO to gradually test the systems and interaction with lunar surface elements, some of which may be adapted for Mars surface exploration. Holding similar functional capabilities as SH, TH is sized to support much longer durations in space and greater logistical independence. Mars Surface Habitat. NASA is still exploring the concept of operations for initial crewed missions to Mars. As such, the Mars Surface Habitat (MSH) concept is still in its infancy as options for mobile, pressurized habitation and stationary habitats are being explored. It is expected MSH will leverage heavily from the lunar SH and possible lunar pressurized rover, however the very different Martian environment will likely necessitate modifications. ISRU Opportunities: Despite the advancements under NASA’s NextSTEP habitation work and continually optimized reference concepts, NASA is facing near-term mass and power challenges that may create opportunities to the ISRU community by providing yet another possible customer for space resources. While NASA desires to use regenerative ECLS systems (ECLSS) for all habitation concepts, their operation comes with initial mass penalties and maintenance overheads when compared to simpler open-loop architectures. Because of this, NASA is currently pro-posing an open-loop, consumables-based architecture for its surface habitats to achieve initial launch and delivery lander mass targets while scarring for the in-corporation of regenerative ECLSS to meet longer mission durations and sustained presence. With such an architecture, oxygen and potable water are needed consumables, which initial ISRU systems may be able to provide in a pilot capacity. Although the TH is expecting to utilize regenerative ECLSS, advancements in lunar surface-based ISRU and possible re-supply of spacecraft in lunar or Mars orbit could significantly reduce the logistical need for ECLSS related spares on TH and possibly allow a similar open-loop and consumables-based architecture. Table 1 Notional ECLSS consumables per mission use for SH and TH [5]. SH (28-day) Open Loop: Water (kg) 288 | Oxygen (kg) 30 TH (1110-day) Closed-Loop: Water (kg) 182 | Oxygen (kg) 123 In addition to ECLSS mass concerns, the SH is facing challenges with energy storage to support operations over periods of darkness exceeding 100 hours. Both battery and fuel cell-based power architectures are being traded, opening options for external power generation and energy storage. One possibility is ISRU-produced H2 and O2 feeding external primary fuel cell systems which could supplement habitation power generation while reducing initial mass and volume until much more powerful fission power systems might be deployed. Conclusion: Significant advancements are being made in evolvable habitation concepts that span from near-term technologies, such as inflatable structures under NextSTEP, to potentially revolutionary capabilities like the lunar surface construction as funded through the Moon-to-Mars Planetary Autonomous Construction Technologies (MMPACT) project [7]. As NASA investigates both heritage capabilities and rap-idly advancing, disruptive technologies, there are likely many near-term opportunities for initial ISRU capabilities to significantly aid human habitation and increase self-sufficiency beyond Earth.

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