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Results for “Heavy Ions”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 325 records · Page 18
All sourcesNASA NTRSDOE OSTI
NASA NTRS2001

Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions

Gene amplification and microsatellite alteration are useful markers of genomic instability in tumor and transformed cell lines. It has been suggested that genomic instability contributes to the progression of tumorigenesis by accumulating genetic changes. In this study, amplification of the carbamyl-P-synthetase, aspartate transcarbamylase, dihydro-orotase (CAD) gene in transformed and tumorigenic human bronchial epithelial (BEP2D) cells induced by either alpha particles or (56)Fe ions was assessed by measuring resistance to N-(phosphonacetyl)-l-aspartate (PALA). In addition, alterations of microsatellite loci located on chromosomes 3p and 18q were analyzed in a series of primary and secondary tumor cell lines generated in nude mice. The frequency of PALA-resistant colonies was 1-3 x 10(-3) in tumor cell lines, 5-8 x 10(-5) in transformed cells prior to inoculation into nude mice, and less than 10(-7) in control BEP2D cells. Microsatellite alterations were detected in all 11 tumor cell lines examined at the following loci: D18S34, D18S363, D18S877, D3S1038 and D3S1607. No significant difference in either PALA resistance or microsatellite instability was found in tumor cell lines that were induced by alpha particles compared to those induced by (56)Fe ions.

Non-NASA Center↗
NASA NTRS1985

The plasma mechanism for preferential acceleration of heavy ions

The induced scattering of ion-acoustic waves on ions is considered for preferential preacceleration of heavy elements. The reconsidered diffusion coefficient in velocity space is used. If the threshold velocity for the main acceleration is linear in charge-to-mass ratio, the induced scattering can account for the observed heavy element abundances in solar cosmic rays.

Kocharov, L. G.↗
NASA NTRS2016

Heavy-Ion Testing of the Freescale Qorivva 32-bit Automotive-Grade MCU

We present single-event effects testing results from a commercially-available automotive microcontroller. We discuss the difficulties encountered testing with commercially-provided evaluation boards while attempting to classify the complex and varied failure modes of a modern 32-bit microcontroller. This work also describes some of the possible advantages to using off-the-shelf automotive-grade electronics for low-risk aerospace applications.

Heavy-Ion Testing↗
NASA NTRS2002

Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions

The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

NASA Center JSC↗
NASA NTRS2001

Clustered DNA damages induced by high and low LET radiation, including heavy ions

Clustered DNA damages--here defined as two or more lesions (strand breaks, oxidized purines, oxidized pyrimidines or abasic sites) within a few helical turns--have been postulated as difficult to repair accurately, and thus highly significant biological lesions. Further, attempted repair of clusters may produce double strand breaks (DSBs). However, until recently, there was no way to measure ionizing radiation-induced clustered damages, except DSB. We recently described an approach for measuring classes of clustered damages (oxidized purine clusters, oxidized pyrimidine clusters, abasic clusters, along with DSB). We showed that ionizing radiation (gamma rays and Fe ions, 1 GeV/amu) does induce such clusters in genomic DNA in solution and in human cells. These studies also showed that each damage cluster results from one radiation hit (and its track), thus indicating that they can be induced by very low doses of radiation, i.e. two independent hits are not required for cluster induction. Further, among all complex damages, double strand breaks comprise--at most-- ~20%, with the other clustered damages being at least 80%.

NASA Discipline Radiation Health↗
NASA NTRS2016

Heavy Ion Irradiation Fluence Dependence for Single-Event Upsets in a NAND Flash Memory

We investigated the single-event effect (SEE) susceptibility of the Micron 16 nm NAND flash, and found that the single-event upset (SEU) cross section varied inversely with cumulative fluence. We attribute the effect to the variable upset sensitivities of the memory cells. Furthermore, the effect impacts only single cell upsets in general. The rate of multiple-bit upsets remained relatively constant with fluence. The current test standards and procedures assume that SEU follow a Poisson process and do not take into account the variability in the error rate with fluence. Therefore, traditional SEE testing techniques may underestimate the on-orbit event rate for a device with variable upset sensitivity.

NAND flash memory↗
NASA NTRS1998

Effect of track structure and radioprotectors on the induction of oncogenic transformation in murine fibroblasts by heavy ions

The oncogenic potential of high-energy 56Fe particles (1 GeV/nucleon) accelerated with the Alternating Gradient Synchrotron at the Brookhaven National Laboratory was examined utilizing the mouse C3H 10T1/2 cell model. The dose-averaged LET for high-energy 56Fe is estimated to be 143 keV/micrometer with the exposure conditions used in this study. For 56Fe ions, the maximum relative biological effectiveness (RBEmax) values for cell survival and oncogenic transformation were 7.71 and 16.5 respectively. Compared to 150 keV/micrometer 4He nuclei, high-energy 56Fe nuclei were significantly less effective in cell killing and oncogenic induction. The prostaglandin E1 analog misoprostol, an effective oncoprotector of C3H 10T1/2 cells exposed to X rays, was evaluated for its potential as a radioprotector of oncogenic transformation with high-energy 56Fe. Exposure of cells to misoprostol did not alter 56Fe cytotoxicity or the rate of 56Fe-induced oncogenic transformation.

NASA Discipline Radiation Health↗
NASA NTRS1997

Ultra Heavy Ion Collector (UHIC)

The purpose of this final report is to study the propagation of heavy nuclei in cosmic radiation. Topics include: Mass Distributions of Fragments from the Interactions of 600 MeV/n Silver Nuclei; Charge-pickup by Heavy Relativistic Nuclei; Fragmentation and Propagation Heavy UH Cosmic Ray Nuclei; Nuclear Fragmentation Parameters Needed for Interpretation of Observed Fluxes of UH Cosmic Ray Nuclei; Fragmentation and Electromagnetic Dissociation of 10.6 GeV/nucleon (197) Au Nuclei; Nuclear Interaction Cross Sections for UltraHeavy Nuclei; The Charge-Changing Fragmentation of 10.6 GeV/nucleon 197 Au Nuclei; Fragmentation Cross Sections of Relativistic 84/36 Kr and 109/47 Ag Nuclei in Targets from Hydrogen to Lead; Mission Concept for the Study of Ultraheavy Galactic Cosmic Rays; and Propagation of the Heaviest UH - Cosmic Ray Nuclei.

Stone, E. C.↗
NASA NTRS1991

Cross section for production of low-energy electron-positron pairs by relativistic heavy ions

Starting with the lowest-order unscreened QED matrix element for electron-positron pair production by heavy charged particles, the paper calculates the cross section for this process differential in all independent variables and valid for all pair energies small compared to the incident particle energy. Integration over the possible emission angles of one of the pair members gives an expression that is valid for low-energy pairs that can be compared with previous work based on the Weizsaecker-Williams method. Integration over the possible angles of the other pair member then yields an expression identical to one derived by Racah. The high energy-transfer limit of the expression for the cross section integrated over electron and positron angles is found to be identical to that of Kelner in the unscreened case.

Eby, P. B.↗
NASA NTRS1992

Light-heavy ion measurements in CR-39 located on the Earth side of LDEF

The azimuthal angle distribution and the charge and energy spectra of selected light-heavy (3 less than or = Z less than or = 8) stopping particles were measured in a single layer of CR-39 plastic nuclear track detector (PNTD) from the stack of the A0015 experiment located on the Earth-end of the satellite. The directional incidence of the trapped protons is studied by comparing the azimuthal angle distribution of selected recoils, obtained in the LDEF detectors, to that obtained through calibrations of PNTDs with exposure performed with 200 MeV proton beams from different directions. Similar measurements will be performed in a CR-39 sample exposed on the space-end of the LDEF satellite for intercomparison. The experimental results will also be compared to theoretical calculations.

Csige, I.↗
NASA NTRS1993

Light-heavy ion measurements in CR-39 located on the Earth side of LDEF

The azimuthal angle distribution and the charge and energy spectra of selected light-heavy (5 less than or equal to Z less than or equal to 8) stopping particles were measured in a single layer of CR-39 plastic nuclear track detector (PNTD) from the stack of the A0015 experiment located on the Earth-end of the LDEF satellite. The directional incidence of the trapped protons is studied by comparing the azimuthal angle distribution of selected recoils, obtained in the LDEF detectors, to that obtained through calibrations of PNTD's with exposures performed with 200 MeV proton beams from different directions.

Csige, I.↗
NASA NTRS1979

Possible detection of energetic Jovian heavy ions at Skylab orbit

Evidence for the presence of sodium ions at a concentration about 10% that of oxygen among the particles with energies 10 to 20 MeV/nucleon seen with a detector on Skylab suggests that Jupiter is a significant source of energetic heavy particles inside the earth's magnetosphere. A numerical estimate based on the density of energetic sodium ions at 50 Jupiter radii measured on Voyager 1 indicates that the source strength is adequate.

Price, P. B.↗
NASA NTRS1977

Pauli correlations in heavy-ion collisions at high energies

We calculate the effects of short-range correlations on the Glauber expansion for nucleus-nucleus collisions using the Fermi gas model for nuclei. When we neglect the Pauli principle for collisions between heavy nuclei, calculation of the optical phase-shift function leads to non-unitary results and we cannot obtain cross sections. When we include Pauli correlations we find important cancellations in the optical phase-shift function, which make possible the calculation of total and differential cross sections for heavy nuclei.

Franco, V.↗
NASA NTRS2008

Heavy Ion Carcinogenesis and Human Space Exploration

Prior to the human exploration of Mars or long duration stays on the Earth s moon, the risk of cancer and other diseases from space radiation must be accurately estimated and mitigated. Space radiation, comprised of energetic protons and heavy nuclei, has been show to produce distinct biological damage compared to radiation on Earth, leading to large uncertainties in the projection of cancer and other health risks, while obscuring evaluation of the effectiveness of possible countermeasures. Here, we describe how research in cancer radiobiology can support human missions to Mars and other planets.

Cucinotta, Francis A.↗
NASA NTRS1977

High-energy heavy-ion scattering and the optical phase shift function

Within the framework of the Glauber approximation, an exact expression for the optical phase shift function is derived which takes into account the center-of-mass correlation function. We calculate total and differential cross sections using the first-order term for the shift function and compare them with the usual (first-order) optical limit results and, for the lighter nuclei, with the exact Glauber results. The nucleus-nucleus elastic scattering amplitude does not exhibit the large-q divergence which characterizes the usual optical limit. The obtained results improve the calculated total and differential cross sections dramatically for light nuclei, and significantly for medium and heavy nuclei.

Franco, V.↗