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At least 37 records · Page 2

System for particle concentration and detection

A new microfluidic system comprising an automated prototype insulator-based dielectrophoresis (iDEP) triggering microfluidic device for pathogen monitoring that can eventually be run outside the laboratory in a real world environment has been used to demonstrate the feasibility of automated trapping and detection of particles. The system broadly comprised an aerosol collector for collecting air-borne particles, an iDEP chip within which to temporarily trap the collected particles and a laser and fluorescence detector with which to induce a fluorescence signal and detect a change in that signal as particles are trapped within the iDEP chip.

47 OTHER INSTRUMENTATION↗

Search for photons above 10 18 eV by simultaneously measuring the atmospheric depth and the muon content of air showers at the Pierre Auger Observatory

The Pierre Auger Observatory is the most sensitive instrument to detect photons with energies above 1 0 17 eV . It measures extensive air showers generated by ultrahigh energy cosmic rays using a hybrid technique that exploits the combination of a fluorescence detector with a ground array of particle detectors. The signatures of a photon-induced air shower are a larger atmospheric depth of the shower maximum ( X max ) and a steeper lateral distribution function, along with a lower number of muons with respect to the bulk of hadron-induced cascades. In this work, a new analysis technique in the energy interval between 1 and 30 EeV ( 1 EeV = 1 0 18 eV ) has been developed by combining the fluorescence detector-based measurement of X max with the specific features of the surface detector signal through a parameter related to the air shower muon content, derived from the universality of the air shower development. No evidence of a statistically significant signal due to photon primaries was found using data collected in about 12 years of operation. Thus, upper bounds to the integral photon flux have been set using a detailed calculation of the detector exposure, in combination with a data-driven background estimation. The derived 95% confidence level upper limits are 0.0403, 0.01113, 0.0035, 0.0023, and 0.0021 km − 2 sr − 1 yr − 1 above 1, 2, 3, 5, and 10 EeV, respectively, leading to the most stringent upper limits on the photon flux in the EeV range. Compared with past results, the upper limits were improved by about 40% for the lowest energy threshold and by a factor 3 above 3 EeV, where no candidates were found and the expected background is negligible. The presented limits can be used to probe the assumptions on chemical composition of ultrahigh energy cosmic rays and allow for the constraint of the mass and lifetime phase space of super-heavy dark matter particles. Published by the American Physical Society 2024

79 ASTRONOMY AND ASTROPHYSICS↗

Auger at the Telescope Array: Recent Progress Toward a Direct Cross-Calibration of Surface-Detector Stations

Since 2007 the Telescope Array Project (TA) and the Pierre Auger Observatory (Auger) have collected extensive data sets spanning several orders of magnitude in energy of the cosmic-ray spectrum. In both experiments the bulk of data is generated from the surface-detector (SD) array, which is energetically calibrated with fluorescence detectors using a hybrid approach. However, each experiment has implemented a different SD station design, resulting in different sensitivities of extensive air-shower channels. Understanding these differences and any potential unforeseen systematic errors is essential for future joint analyses. In this paper we present an update on the progress of an in-situ cross-calibration program. We focus on recent hardware installations which enable the read out of co-located Auger and TA SD stations at the TA central laser facility (CLF). We also present a preliminary analysis of event signals observed at the CLF.

79 ASTRONOMY AND ASTROPHYSICS↗

The Pierre Auger Observatory Upgrade - Preliminary Design Report

The Pierre Auger Observatory has begun a major Upgrade of its already impressive capabilities, with an emphasis on improved mass composition determination using the surface detectors of the Observatory. Known as AugerPrime, the upgrade will include new 4 m 2 plastic scintillator detectors on top of all 1660 water-Cherenkov detectors, updated and more flexible surface detector electronics, a large array of buried muon detectors, and an extended duty cycle for operations of the fluorescence detectors. This Preliminary Design Report was produced by the Collaboration in April 2015 as an internal document and information for funding agencies. It outlines the scientific and technical case for AugerPrime. We now release it to the public via the arXiv server. We invite you to review the large number of fundamental results already achieved by the Observatory and our plans for the future.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Nanoscale measurements of proton tracks using fluorescent nuclear track detectors

Purpose: The authors describe a method in which fluorescence nuclear track detectors (FNTDs), novel track detectors with nanoscale spatial resolution, are used to determine the linear energy transfer (LET) of individual proton tracks from proton therapy beams by allowing visualization and 3D reconstruction of such tracks. Methods: FNTDs were exposed to proton therapy beams with nominal energies ranging from 100 to 250 MeV. Proton track images were then recorded by confocal microscopy of the FNTDs. Proton tracks in the FNTD images were fit by using a Gaussian function to extract fluorescence amplitudes. Histograms of fluorescence amplitudes were then compared with LET spectra. Results: The authors successfully used FNTDs to register individual proton tracks from high-energy proton therapy beams, allowing reconstruction of 3D images of proton tracks along with delta rays. The track amplitudes from FNTDs could be used to parameterize LET spectra, allowing the LET of individual proton tracks from therapeutic proton beams to be determined. Conclusions: FNTDs can be used to directly visualize proton tracks and their delta rays at the nanoscale level. Because the track intensities in the FNTDs correlate with LET, they could be used further to measure LET of individual proton tracks. This method may be useful for measuring nanoscale radiation quantities and for measuring the LET of individual proton tracks in radiation biology experiments.

60 APPLIED LIFE SCIENCES↗

Mass composition studies of Ultra High Energy cosmic rays through the measurement of the Muon Production Depths at the Pierre Auger Observatory

The Pierre Auger Observatory (Auger) in Argentina studies Ultra High Energy Cosmic Rays (UHECRs) physics. The flux of cosmic rays at these energies (above 1018 eV) is very low (less than 100 particle/km2-year) and UHECR properties must be inferred from the measurements of the secondary particles that the cosmic ray primary produces in the atmosphere. These particles cascades are called Extensive Air Showers (EAS) and can be studied at ground by deploying detectors covering large areas. The EAS physics is complex, and the properties of secondary particles depend strongly on the first interaction, which takes place at an energy beyond the ones reached at accelerators. As a consequence, the analysis of UHECRs is subject to large uncertainties and hence many of their properties, in particular their composition, are still unclear. Two complementary techniques are used at Auger to detect EAS initiated by UHE- CRs: a 3000 km2 surface detector (SD) array of water Cherenkov tanks which samples particles at ground level and fluorescence detectors (FD) which collect the ultraviolet light emitted by the de-excitation of nitrogen nuclei in the atmosphere, and can operate only in clear, moonless nights. Auger is the largest cosmic rays detector ever built and it provides high-quality data together with unprecedented statistics. The main goal of this thesis is the measurement of UHECR mass composition using data from the SD of the Pierre Auger Observatory. Measuring the cosmic ray composition at the highest energies is of fundamental importance from the astrophysical point of view, since it could discriminate between different scenarios of origin and propagation of cosmic rays. Moreover, mass composition studies are of utmost importance for particle physics. As a matter of fact, knowing the composition helps in exploring the hadronic interactions at ultra-high energies, inaccessible to present accelerator experiments.

79 ASTRONOMY AND ASTROPHYSICS↗

Method for determining surface coverage by materials exhibiting different fluorescent properties

An improved method for detecting, measuring, and distinguishing crop residue, live vegetation, and mineral soil is presented. By measuring fluorescence in multiple bands, live and dead vegetation are distinguished. The surface of the ground is illuminated with ultraviolet radiation, inducing fluorescence in certain molecules. The emitted fluorescent emission induced by the ultraviolet radiation is measured by means of a fluorescence detector, consisting of a photodetector or video camera and filters. The spectral content of the emitted fluorescent emission is characterized at each point sampled, and the proportion of the sampled area covered by residue or vegetation is calculated.

Chappelle, Emmett W.↗

Final Report for DoE Grant DE-SC-0011689 - Studies of Particle Astrophysics at the Cosmic Frontier

Our research focuses on the “Cosmic Frontier”, one of the three principle thrusts of the DoE Office of Science High Energy Physics research program. The 2013 community summer study “Snowmass on the Mississippi” catalyzed joint work to describe the status and future prospects of this research thrust. Over its history, the field of cosmic ray studies has provided many discoveries of central importance to the the progress of high energy physics, including the identification of new elementary particles, measurements of particle interactions far above accelerator energies, and the confirmation of neutrino oscillations. In our research we continued this tradition, employing 2 instruments (the Auger Observatory and the HAWC Observatory) to study high energy physics questions using cosmic rays. One approach to addressing particle physics questions at the cosmic frontier is to study the very highest energy cosmic rays. This has been the major thrust of our research effort. The two largest currently operating ultra-high energy cosmic ray (UHECR) observatories are the Pierre Auger Observatory in the Southern hemisphere, covering an area of 3000 km 2 and the Telescope Array (TA) in the Northern hemisphere, covering about 700 km 2 . The observatories sample the cosmic ray air showers at ground level (with 1660 water Cerenkov stations in the Auger surface detector), and also measure the longitudinal development of air showers on clear moonless nights (approx. 10% of the events) using atmospheric fluorescence detectors. The observatories have recently installed low energy extensions, which provide an overlap with the LHC energy regime. The Auger and TA teams have established joint working groups to discuss experimental methods, compare data analyses and modeling, and perform cross calibrations. Another approach is to study high energy gamma rays. The High Altitude Water Cerenkov (HAWC) gamma-ray observatory is located at 4100 m above sea level near Pico de Orizaba in central Mexico. HAWC is the most sensitive, wide field of view, TeV gamma-ray observatory in operation. After 4 years of construction, operation of the full detector began in March 2015. The HAWC detector contains 300 tanks each 7.3 m in diameter and 4.5 m deep containing pure water. Each water tank is instrumented with 4 upward-viewing photomultiplier tubes mounted at their bottom. The water tanks record the energy deposited by and arrival times of the constituent components of impinging extensive air showers (EAS). The tanks are close-packed to optimize the spatial sampling of the shower front. The distribution of deposited energy across the shower is used for gamma-hadron rejection. Showers with large energy deposit away from the core are rejected as being hadron-initiated. The detector operates at full efficiency above 3 TeV. The angular resolution above that energy approaches 0.1 degree. As the detector operates both day and night, the wide field of view of ~2 sr, allows ~2/3 of the sky to be observed each day.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

MOD: An Organic Detector for the Future Exploration of Mars

The Mars Organic Detector (MOD) is designed to assess whether organic compounds, possibly associated with life, are present in Martian rock and soil samples. MOD has a detection limit that is at least two orders of magnitude more sensitive than the Viking GCMS. MOD is focused on detecting amino acids, amines and PAH (polycyclic aromatic hydrocarbons). Amino acids play an essential role in biochemistry on Earth and PAH are widespread throughout the universe and can provide an indication of the delivery of meteoritic organic material to Mars. The advantage of MOD is the absence of wet chemistry and its simple and robust design. The sample will be extracted from the mineral matrix (0.1 - 1 g of rock-powder) using sublimation and analyzed with a fluorescence detector. The isolation method is based on the fact that amino acids and PAH are volatile at temperatures greater than 150C. The fluorescence detection scheme is based on UV excitation with LED's, optical filters, PrN diode photon detector and a sample calibration reservoir. Fluorescamine is used as a fluorescing reagent for amino acids and amines, while PAH are naturally fluorescent. There is no sample preparation required and the turnaround time for a single analysis is on the order of minutes.

Kminek, G.↗

The cloud monitor by an infrared camera at the Telescope Array experiment

The mesurement of the extensive air shower using the fluorescence detectors (FDs) is affected by the condition of the atmosphere. In particular, FD aperture is limited by cloudiness. If cloud exists on the light path from extensive air shower to FDs, fluorescence photons will be absorbed drastically. Therefore cloudiness of FD's field of view (FOV) is one of important quality cut condition in FD analysis. In the Telescope Array (TA), an infrared (IR) camera with 320x236 pixels and a filed of view of 25.8 deg. x19.5 deg. has been installed at an observation site for cloud monitoring during FD observations. This IR camera measures temperature of the sky every 30 min during FD observation. IR camera is mounted on steering table, which can be changed in elevation and azimuthal direction. Clouds can be seen at a higher temperature than areas of cloudless sky from these temperature maps. In this paper, we discuss the quality of the cloud monitoring data, the analysis method, and current quality cut condition of cloudiness in FD analysis.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Measurement of the Muon Atmospheric Production Depth with the Water Cherenkov Detectors of the Pierre Auger Observatory

Ultra-high-energy cosmic rays (UHECR) are particles of uncertain origin and composition, with energies above 1 EeV (10 18 eV or 0.16 J). The measured flux of UHECR is a steeply decreasing function of energy. The largest and most sensitive apparatus built to date to record and study cosmic ray Extensive Air Showers (EAS) is the Pierre Auger Observatory. The Pierre Auger Observatory has produced the largest and finest amount of data ever collected for UHECR. A broad physics program is being carried out covering all relevant topics of the field. Among them, one of the most interesting is the problem related to the estimation of the mass composition of cosmic rays in this energy range. Currently the best measurements of mass are those obtained by studying the longitudinal development of the electromagnetic part of the EAS with the Fluorescence Detector. However, the collected statistics is small, specially at energies above several tens of EeV. Although less precise, the volume of data gathered with the Surface Detector is nearly a factor ten larger than the fluorescence data. So new ways to study composition with data collected at the ground are under investigation. The subject of this thesis follows one of those new lines of research. Using preferentially the time information associated with the muons that reach the ground, we try to build observables related to the composition of the primaries that initiated the EAS. A simple phenomenological model relates the arrival times with the depths in the atmosphere where muons are produced. The experimental confirmation that the distributions of muon production depths (MPD) correlate with the mass of the primary particle has opened the way to a variety of studies, of which this thesis is a continuation, with the aim of enlarging and improving its range of applicability. We revisit the phenomenological model which is at the root of the analysis and discuss a new way to improve some aspects of the model. We carry out a thorough revision of the original analysis with the aim of understanding the different contributions to the total bias and resolution when building MPDs on an event-by-event basis. We focus on an alternative way to build MPDs by considering average MPDs for ensembles of air-showers, with the aim of enlarging the range of applicability of this kind of analysis. Finally, we analyze how different improvements in the Surface Detector electronics and its internal configuration affect the resolution of the MPD. We conclude by summarizing the main results and discussing potential ways to improve MPD-based mass composition studies.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of the depth of maximum of air-shower profiles with energies between 10 18.5 and 10 20 eV using the surface detector of the Pierre Auger Observatory and deep learning

We report an investigation of the mass composition of cosmic rays with energies from 3 to 100 EeV ( 1 EeV = 10 18 eV ) using the distributions of the depth of shower maximum X max . The analysis relies on ∼ 50 , 000 events recorded by the surface detector of the Pierre Auger Observatory and a deep-learning-based reconstruction algorithm. Above energies of 5 EeV, the dataset offers a 10-fold increase in statistics with respect to fluorescence measurements at the Observatory. After cross-calibration using the fluorescence detector, this enables the first measurement of the evolution of the mean and the standard deviation of the X max distributions up to 100 EeV. Our findings are threefold: (i) The evolution of the mean logarithmic mass toward a heavier composition with increasing energy can be confirmed and is extended to 100 EeV. (ii) The evolution of the fluctuations of X max toward a heavier and purer composition with increasing energy can be confirmed with high statistics. We report a rather heavy composition and small fluctuations in X max at the highest energies. (iii) We find indications for a characteristic structure beyond a constant change in the mean logarithmic mass, featuring three breaks that are observed in proximity to the ankle, instep, and suppression features in the energy spectrum. Published by the American Physical Society 2025

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Tre-DST: A Drug Susceptibility Test for Mycobacterium tuberculosis Using Solvatochromic Trehalose Probes

In 2024, an estimated 10 million people developed Tuberculosis (TB), nearly half a million of whom were infected with drug-resistant tuberculosis (DR-TB). Early detection of infection and drug resistance enables rapid engagement in effective care. Bacterial culture and nucleic acid testing remain the primary diagnostic methods, with smear microscopy being phased out. However, these methods present significant limitations for diagnosing drug resistance, such as lengthy time-to-result for phenotypic tests, as well as the need for prior knowledge of resistance mutations and prohibitive cost for molecular tests. To address this, we developed a rapid phenotypic TB drug susceptibility test, termed Tre-DST, based on novel metabolically incorporated trehalose probes, which specifically detect live mycobacteria. We used the nonpathogenic Mycobacterium smegmatis and the virulence-attenuated Mycobacterium tuberculosis (Mtb) H37Ra or auxotrophic Mtb to demonstrate a strong correlation between cost-effective plate reader results and flow cytometry data, suggesting that the plate reader is a suitable fluorescence detector for Tre-DST. We determined that adding a 1-week incubation step allowed Mtb samples originally seeded at 10 4 CFU/mL to become detectable, over 2 weeks earlier than colony-forming unit analysis. We found that Tre-DST reports on drug susceptibility in a drug-agnostic manner, demonstrating loss of fluorescence with frontline TB drugs as well as the newer drug bedaquiline. Tre-DST distinguished RIF- and INH-resistant auxotrophs from susceptible controls and accurately reported the resistance activity. Ultimately, because Tre-DST is agnostic to mechanisms of drug resistance, this assay is likely compatible with all WHO-recommended and future DR-TB drugs as a diagnostic in reference laboratories.

diagnostics↗

Inference of the Mass Composition of Cosmic Rays with Energies from 10 18.5 to 10 20 eV Using the Pierre Auger Observatory and Deep Learning

We present measurements of the atmospheric depth of the shower maximum X max , inferred for the first time on an event-by-event level using the surface detector of the Pierre Auger Observatory. Using deep learning, we were able to extend measurements of the X max distributions up to energies of 100 EeV ( 10 20 eV ), not yet revealed by current measurements, providing new insights into the mass composition of cosmic rays at extreme energies. Gaining a 10-fold increase in statistics compared to the fluorescence detector data, we find evidence that the rate of change of the average X max with the logarithm of energy features three breaks at 6.5 ± 0.6 ( stat ) ± 1 ( syst ) EeV , 11 ± 2 ( stat ) ± 1 ( syst ) EeV , and 31 ± 5 ( stat ) ± 3 ( syst ) EeV , in the vicinity to the three prominent features (ankle, instep, suppression) of the cosmic-ray flux. The energy evolution of the mean and standard deviation of the measured X max distributions indicates that the mass composition becomes increasingly heavier and purer, thus being incompatible with a large fraction of light nuclei between 50 and 100 EeV. Published by the American Physical Society 2025

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Measuring excited state lifetime of Rb atoms with pump-probe technique

A technique for measuring the excited state lifetime τ{sub ex} of optical transitions in alkali atoms is presented. It is a form of pump-probe technique based on time-resolved optical transmission through the atomic vapor cell. This technique can serve as an alternative to the traditionally used time-resolved photofluorescence methods when measuring alkali vapor cells with heavily quenched fluorescence, where the τ{sub ex} is expected to be on the order of a few nanoseconds, and the highly sensitive fluorescence detectors with sub-nanosecond temporal resolution that are required may not be available. We use this technique to measure the τ{sub ex} of Rb atoms in vapor cells with different buffer gas pressures.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Photon-counting 1.0 GHz-phase-modulation fluorometer

We have constructed an improved version of a photon-counting phase-modulation fluorometer (PC-PMF) with a maximum modulation frequency of 1.0 GHz, where a phase domain measurement is conducted with a time-correlated single-photon-counting electronics. While the basic concept of the PC-PMF has been reported previously by one of the authors, little attention has been paid to its significance, other than its weak fluorescence measurement capability. Recently, we have recognized the importance of the PC-PMF and its potential for fluorescence lifetime measurements. One important aspect of the PC-PMF is that it enables us to perform high-speed measurements that exceed the frequency bandwidths of the photomultiplier tubes that are commonly used as fluorescence detectors. We describe the advantages of the PC-PMF and demonstrate its usefulness based on fundamental performance tests. In our new version of the PC-PMF, we have used a laser diode (LD) as an excitation light source rather than the light-emitting diode that was used in the primary version. We have also designed a simple and stable LD driver to modulate the device. Additionally, we have obtained a sinusoidal histogram waveform that has multiple cycles within a time span to be measured, which is indispensable for precise phase measurements. With focus on the fluorescence intensity and the resolution time, we have compared the performance of the PC-PMF with that of a conventional PMF using the analogue light detection method.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Techniques for measuring aerosol attenuation using the Central Laser Facility at the Pierre Auger Observatory

The Pierre Auger Observatory in Malargüe, Argentina, is designed to study the properties of ultra-high energy cosmic rays with energies above 10(18)eV. It is a hybrid facility that employs a Fluorescence Detector to perform nearly calorimetric measurements of Extensive Air Shower energies. To obtain reliable calorimetric information from the FD, the atmospheric conditions at the observatory need to be continuously monitored during data acquisition. In particular, light attenuation due to aerosols is an important atmospheric correction. The aerosol concentration is highly variable, so that the aerosol attenuation needs to be evaluated hourly. We use light from the Central Laser Facility, located near the center of the observatory site, having an optical signature comparable to that of the highest energy showers detected by the FD. This paper presents two procedures developed to retrieve the aerosol attenuation of fluorescence light from CLF laser shots. Cross checks between the two methods demonstrate that results from both analyses are compatible, and that the uncertainties are well understood. The measurements of the aerosol attenuation provided by the two procedures are currently used at the Pierre Auger Observatory to reconstruct air shower data.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Absolute energy calibration of FD by an electron linear accelerator for Telescope Array

The primary energy of the ultra-high energy cosmic rays(UHECR) are measured with the number of fluorescence photons which are detected with fluorescence detectors(FD) in the Telescope Array experiment(TA). Howevery since there is large uncertinty as 19% in the measurement of the energy scale, the most important theme is improvement of the energy calibration. The electron light source(ELS) is a small electron linear accelerator for new energy calibration. The ELS is located 100 m far from the FD station, and injects electron beam which is accelerated to 40 MeV energy into the sky. We can calibrate the FD energy scale by detection the air shower directly which is generated by the electron beam. The ELS was developed in KEK Japan, and moved to the TA site in March 2009. We started the beam operation in September 2010, in consequence we detected the air shower which was generated by electron beam in the air. The output kinetic energy of the electron beam was 41.1 MeV, we adjusted the output charge from 40 to 140 pC/pulse. We expect that we can improve the uncertinty of the energy scale to about 10% with the ELS, futhermore ELS will be a very useful apparatus for R and D of future UHECR observation.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗