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At least 379 records · Page 21

Shuttle/spacelab contamination environment and effects handbook

This handbook is intended to assist users of the Spacelab/Space Transportation System by providing contamination environments and effects information that may be of value in planning, designing, manufacturing, and operating a space flight experiment. A summary of available molecular and particulate contamination data on the Space Transportation System and its facilities is presented. Contamination models, contamination effects, and protection methods information are also presented. In addition to contamination, the effects of the space environments at STS altitudes on spacecraft materials are included. Extensive references, bibliographies, and contacts are provided.

Bareiss, L. E.↗

Automated Miniaturized Instrument for Space Biology Applications and the Monitoring of the Astronauts Health Onboard the ISS

Human space travelers experience a unique environment that affects homeostasis and physiologic adaptation. The spacecraft environment subjects the traveler to noise, chemical and microbiological contaminants, increased radiation, and variable gravity forces. As humans prepare for long-duration missions to the International Space Station (ISS) and beyond, effective measures must be developed, verified and implemented to ensure mission success. Limited biomedical quantitative capabilities are currently available onboard the ISS. Therefore, the development of versatile instruments to perform space biological analysis and to monitor astronauts' health is needed. We are developing a fully automated, miniaturized system for measuring gene expression on small spacecraft in order to better understand the influence of the space environment on biological systems. This low-cost, low-power, multi-purpose instrument represents a major scientific and technological advancement by providing data on cellular metabolism and regulation. The current system will support growth of microorganisms, extract and purify the RNA, hybridize it to the array, read the expression levels of a large number of genes by microarray analysis, and transmit the measurements to Earth. The system will help discover how bacteria develop resistance to antibiotics and how pathogenic bacteria sometimes increase their virulence in space, facilitating the development of adequate countermeasures to decrease risks associated with human spaceflight. The current stand-alone technology could be used as an integrated platform onboard the ISS to perform similar genetic analyses on any biological systems from the tree of life. Additionally, with some modification the system could be implemented to perform real-time in-situ microbial monitoring of the ISS environment (air, surface and water samples) and the astronaut's microbiome using 16SrRNA microarray technology. Furthermore, the current system can be enhanced substantially by combining it with other technologies for automated, miniaturized, high-throughput biological measurements, such as fast sequencing, protein identification (proteomics) and metabolite profiling (metabolomics). Thus, the system can be integrated with other biomedical instruments in order to support and enhance telemedicine capability onboard ISS. NASA's mission includes sustained investment in critical research leading to effective countermeasures to minimize the risks associated with human spaceflight, and the use of appropriate technology to sustain space exploration at reasonable cost. Our integrated microarray technology is expected to fulfill these two critical requirements and to enable the scientific community to better understand and monitor the effects of the space environment on microorganisms and on the astronaut, in the process leveraging current capabilities and overcoming present limitations.

Human space travelers↗

The effect of the low Earth orbit environment on space solar cells: Results of the advanced photovoltaic experiment (S0014)

The Advanced Photovoltaic Experiment (APEX), containing over 150 solar cells and sensors, was designed to generate laboratory reference standards as well as to explore the durability of a wide variety of space solar cells. Located on the leading edge of the Long Duration Exposure Facility (LDEF), APEX received the maximum possible dosage of atomic oxygen and ultraviolet radiation, as well as enormous numbers of impacts from micrometeoroids and debris. The effect of the low earth orbital (LEO) environment on the solar cells and materials of APEX will be discussed in this paper. The on-orbit performance of the solar cells, as well as a comparison of pre- and postflight laboratory performance measurements, will be presented.

Brinker, David J.↗

Long Duration Exposure Facility (LDEF) results

This paper presents an overview of the initial observations of the Long Duration Exposure Facility and the 57 onboard experiments which were retrieved from space on January 12, 1990, during the Space Shuttle STS Mission 32. The facility and the 57 science, technology, and applications experiments had remained in space for almost 6 years. The initial and the continuing observations of this retrieved hardware have provided, and will continue to provide for a number of years in the future, a wealth of basic science data on the environments of near-earth space and a unique opportunity to observe and study long duration synergistic effects of these space environments on a large array of typical spacecraft materials and systems.

Kinard, William H.↗

A Comparison of Molecular and Histopathological Changes in Mouse Intestinal Tissue Following Whole-Body Proton- or Gamma-Irradiation

There are many consequences following exposure to the space radiation environment which can adversely affect the health of a crew member. Acute radiation syndrome (ARS) involving nausea and vomiting, damage to radio-sensitive tissue such as the blood forming organs and gastrointestinal tract, and cancer are some of these negative effects. The space radiation environment is ample with protons and contains gamma rays as well. Little knowledge exists to this point, however, regarding the effects of protons on mammalian systems; conversely several studies have been performed observing the effects of gamma rays on different animal models. For the research presented here, we wish to compare our previous work looking at whole-body exposure to protons using a mouse model to our studies of mice experiencing whole-body exposure to gamma rays as part of the radio-adaptive response. Radio-adaptation is a well-documented phenomenon in which cells exposed to a priming low dose of radiation prior to a higher dose display a reduction in endpoints like chromosomal aberrations, cell death, micronucleus formation, and more when compared to their counterparts receiving high dose-irradiation only. Our group has recently completed a radio-adaptive experiment with C57BL/6 mice. For both this study and the preceding proton research, the gastrointestinal tract of each animal was dissected four hours post-irradiation and the isolated small intestinal tissue was fixed in formalin for histopathological examination or snap-frozen in liquid nitrogen for RNA isolation. Histopathologic observation of the tissue using standard H&E staining methods to screen for morphologic changes showed an increase in apoptotic lesions for even the lowest doses of 0.1 Gy of protons and 0.05 Gy of gamma rays, and the percentage of apoptotic cells increased with increasing dose. A smaller percentage of crypts showed 3 or more apoptotic lesions in animals that received 6 Gy of gamma-irradiation compared to mice receiving only 2 Gy of protons. Tissue of the gastrointestinal tract was also homogenized and RNA was isolated for cDNA synthesis and real-time PCR analysis. Inspecting apoptotic lesions of the duodenum of the small intestine as an endpoint of damage did not reveal a radio-adaptive response in C57BL/6 mice at the four hour time point. Results of gene expression changes showed consistent up or down regulation of a number of genes for all of the exposure doses that may play a role in proton-induced apoptosis. Preliminary results of gene expression alterations as a result of gamma-irradiation revealed a wealth of genes involved in oxidative stress and antioxidant defense processes being up- or down-regulated only at the highest exposure dose of 6 Gy and the combined dose of 5 cGy with 6 Gy. Those animals undergoing only 5 cGy of gamma-irradiation showed very little modification of gene expression. Taken together these results lead us to conclude that protons cause more severe morphologic damage to the duodenum of the small intestine at a dose of 2 Gy than a higher dose of 6 Gy of gamma rays to the same organ. Both protons and gamma rays lead to significant variation in gene expression at high doses in the small intestine and these changes may provide insight into the mechanism of injury seen in the gastrointestinal tract following radiation exposure. Astronauts experiencing prolonged exposure to protons in the low Earth orbit and in deep space, and experiencing acute exposure to protons from solar particle events, may face biological consequences that will impact a mission s success. We will continue this work by studying, quantifying, and comparing damage due to protons and gamma rays in the small intestine as well as other organs in a time-dependent manner.

Purgason, Ashley↗

Degradation of optical components in a space environment

The objective of the Phillips Laboratory (PL) Long Duration Exposure Facility (LDEF) experiment is to determine the adverse effects of the natural space environment on laser optical component and coating materials. The LDEF experiment provides a unique opportunity for the study of optical material response to an extended low earth orbit space exposure. The PL samples consist of 10 sets of the six materials each. The materials are uncoated fused silica, magnesium fluoride coated fused silica, uncoated molybdenum, molybdenum coated with chromium, silver and thorium fluoride, diamond turned copper, and diamond turned nickel plated copper. Performance degradation will be correlated to establish trends between sample location, duration of exposure, atomic oxygen exposure and other space environmental conditions. This paper discusses the results of the tests thus far performed on the LDEF samples and the plans for the future.

Dehainaut, Linda L.↗

Study of the space environmental effects on spacecraft engineering materials

The space environment in which the Space Station Freedom and other space platforms will orbit is truly a hostile environment. For example, the current estimates of the integral fluence for electrons above 1 Mev at 2000 nautical miles is above 2 x 10(exp 10) electrons/sq cm/day. and the proton integral fluence is above 1 x 109 protons/sq cm/day. At the 200 - 400 nautical miles, which is more representative of the altitude which will provide the environment for the Space Station, each of these fluences will be proportionately less; however, the data indicates that the radiation environment will obviously have an effect on structural materials exposed to the environment for long durations. The effects of this combined environment is the issue which needs to be understood for the long term exposure of structures in space. In order to better understand the effect of these hostile phenomena on spacecraft, several types of studies are worth performing in order to simulate at some level the effect of the environment. For example the effect of protons and electrons impacting structural materials are easily simulated through experiments using the Van de Graff and Pelletron accelerators currently housed in the Environmental Effects Facility at MSFC. Proton fluxes with energies of 700 Kev-2.5 Mev can be generated and used to impinge on sample targets to determine the effects of the particles. Also the Environmental Effects Facility has the capability to generate electron beams with energies from 700 Kev to 2.5 Mev. These facilities will be used in this research to simulate space environmental effects from energetic particles. Ultraviolet radiation, particularly in the ultraviolet (less than 400 nm wavelength) is less well characterized at this time. The Environmental Effects Facility has a vacuum system dedicated to studying the effects of ultraviolet radiation on specific surface materials. This particular system was assembled in a previous study (NAS8-38609) in order to perform a variety of experiments on materials proposed for the Space Station. That system has continued to function as planned and has been used in carrying out portions of the proposed study.

Obrien, Susan K.↗

Results from investigations in the NASA/MSFC TWT on a .004 scale model space shuttle launch vehicle (model 13P-OTS) to determine gas supply strut effects on model pressure environment (IA53)

The Rockwell Space Shuttle Launch Vehicle components were tested in a Trisonic Wind Tunnel. Pressure measurements were made on the aft portion, in the base regions, and on the wing surfaces. Axial force determination were made from the pressure data. Data were recorded with the model at zero degrees angle of attack and sideslip through a Mach number from 0.9 to 3.0. The only configuration changes investigated were strut mounting techniques and gas line fairing location between the external tank and the orbiter.

Garton, W. P.↗

Radiation Effects on Emerging Technologies: Implications of Space Weather Risk Management

As NASA and its space partners endeavor to develop a network of satellites capable of supporting humankind's needs for advanced space weather prediction and understanding, one of the key challenges is to design a space system to operate in the natural space radiation environment In this paper, we present a description of the natural space radiation environment, the effects of interest to electronic or photonic systems, and a sample of emerging technologies and their specific issues. We conclude with a discussion of operations in the space radiation hazard and considerations for risk management.

LaBel, Kenneth A.↗

Second Symposium on Protection Against Radiations in Space

All space vehicles will be exposed to natural charged particle radiation fields. The effects and possible problems imposed by such radiations are of great concern to those actively engaged in the exploration of space. Materials and components, which may be damaged by the radiation, frequently can be replaced by more radiation resistant items; however, replacement systems are not always possible or practical and, hence, protective measures in the form of shielding must be employed. (One of the more radiation-sensitive systems to be flown in space is man himself.) Many groups are engaged in research on the attenuation and penetration of high-energy space radiation and on the development of methods for the design of shielding which affords protection against the radiation. The purpose of the Second Symposium on Protection Against Radiations in Space, like that of the First, was to bring these groups together to exchange information and share ideas. These proceedings are the written record of the Second Symposium. Invited papers covering the space radiation environment, radiobiological effects, and radiation effects on materials and components comprised the first three sessions. By defining the radiation problems in space and providing for the proper assessment of the radiation effects and shielding requirements, these papers helped to establish the necessary background for the shielding papers which followed in the fourth session.

radiation protection↗

Environmental effects on spacecraft materials

The effects on the natural space environments on materials are presented, which may be used for SDI applications. The current state-of-the-art knowledge of those effects was studied, and a literature search, a questionnaire mailing, and some visits to NASA and Air Force research facilities were performed. Phase 2 will be a study of what materials may be used for SDI applications and to what natural space environments they may be vulnerable. Deficiencies in knowledge of the effects of the natural space environments on these materials are to be identified and recommendations are to be made to eliminate these knowledge deficiencies.

Haffner, J. W.↗

The flight telerobotic servicer project: A technical overview

The Flight Telerobotic Servicer (FTS) technical challenge is the development and integration of a spaceflight quality system with both teleoperative and autonomous capabilities. The system must be safe and reliable in the space environment. Background and rationale leading to the desired FTS telerobotic capabilities are provided. Some of the specific technical requirements to which the FTS must be designed in order to meet the projects goals and operate effectively in the space environment are described.

Mccain, Harry G.↗

Effects Of Five-Ion Galactic Cosmic Radiation Simulation On Immune Function, Brain, And Behavior In Male And Female Mice

Exposure to galactic cosmic radiation is a principal consideration of spaceflight missions, and with upcoming missions to the Moon and Mars, it is increasingly imperative to elucidate the effects of space travel beyond the lower Earth orbit. Additionally, with the first female astronaut to soon travel to the Moon there is a strong need to understand the biological sex differences to adaptation to the deep space environment. While the effects of spaceflight on the nervous system are not fully known, studies in animal models have shown that exposure to ionizing radiation can cause neuronal damage and lead to downstream cognitive and behavioral deficits. To simulate the type of radiation exposure occurring during spaceflight, model organisms can be exposed to relevant doses via Five-Ion Galactic Cosmic Radiation Simulation at the NASA National Space Radiation Laboratory at Brookhaven National Laboratory. We have investigated the neurobehavioral responses to space environment-like radiation exposure. Male and female 23–24-week-old mice (age-matched to average astronaut age) were exposed to 5, 15 and 50 cGy. Following exposure, immune, brain and behavioral (sensorimotor, risk-taking and cognitive) measures were acquired at ‘Acute’ (IR+24hrs, IR+72hrs), ‘Intermediate’ (IR+14 days) and ‘Delayed’ (IR+28 to IR+124 days) to inform biological responses anticipated during a transit to Moon and Mars. There were pronounced sex differences observed in all outcome measurements, while very few radiation induced effects were observed. Those dose effects that were observed were primarily in cytokine expression and less so in behavioral measurements. Further studies will investigate if radiation, microgravity and social isolation combine synergistically to trigger an oxidative stress response that alters immune homeostasis, brain structure/function, and neurobehavioral/cognitive performance, ultimately to characterize risks and identify appropriate countermeasures in both women and men in anticipation of future deep space missions.

Stephanie Puukila↗

Space Active Modular Materials Experiments (SAMMES): Low Earth Orbital mission aboard the Space Test Experiments STEP-3 platform

The requirement of satellite systems to survive in the space environment for 5 to 10 years to achieve greater cost effectiveness is discussed. Characterization of the orbital space environment and its effects on spacecraft systems have received considerable research attention. Instrumentation for long term measurement of key physical parameters characterizing the low Earth orbit (LEO) environment and its effects on degradation of spacecraft materials and solar arrays is reported. These measurements enable active, real time monitoring of the health of spacecraft and payload systems. SAMMES is designed to be autonomous, compact, low power, and lightweight.

Joshi, P.↗

Space Environment Testing of Photovoltaic Array Systems

To successfully operate a photovoltaic (PV) array system in space requires planning and testing to account for the effects of the space environment. It is critical to understand space environment interactions not only on the PV components, but also the array substrate materials, wiring harnesses, connectors, and protection circuitry.

Phillips, Brandon↗

Response of composite materials to the Space Station orbit environment

The rationale for selecting composite materials with an anodized aluminum foil coating for the Space Station is presented. Data on the effects of the space service environment on these materials are given. Results are also presented on the effect of optical properties of an aluminum/aluminum oxide coating on the thermal balance of the cylindrical structural members. The resistance of this coating to solar ultraviolet degradation is discussed.

Tompkins, S. S.↗

Spacecraft environments interactions: Protecting against the effects of spacecraft charging

The effects of the natural space environments on spacecraft design, development, and operation are the topic of a series of NASA Reference Publications currently being developed by the Electromagnetics and Environments Branch, Systems Analysis and Integration Laboratory, Marshall Space Flight Center. This primer, second in the series, describes the interactions between a spacecraft and the natural space plasma. Under certain environmental/spacecraft conditions, these interactions result in the phenomenon known as spacecraft charging. It is the focus of this publication to describe the phenomenon of spacecraft charging and its possible adverse effects on spacecraft and to present the key elements of a Spacecraft Charging Effects Protection Plan.

Herr, J. L.↗