Emergent strongly coupled ultraviolet fixed point in four dimensions with eight Kähler-Dirac fermions
Not Available
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
SEARCH · Search NASA
Results for “Conformal models”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Dark matter from a conformal Dark Sector
We consider theories in which a dark sector is described by a Conformal Field Theory (CFT) over a broad range of energy scales. A coupling of the dark sector to the Standard Model breaks conformal invariance. While weak at high energies, the breaking grows in the infrared, and at a certain energy scale the theory enters a confined (hadronic) phase. One of the hadronic excitations can play the role of dark matter. We study a “Conformal Freeze-In” cosmological scenario, in which the dark sector is populated through its interactions with the SM at temperatures when it is conformal. In this scenario, the dark matter relic density is determined by the CFT data, such as the dimension of the CFT operator coupled to the Standard Model. We show that this simple and highly predictive model of dark matter is phenomenologically viable. The observed relic density is reproduced for a variety of SM operators (“portals”) coupled to the CFT, and the resulting models are consistent with observational constraints. The mass of the COFI dark matter candidate is predicted to be in the keV-MeV range.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Soft pion scattering in infrared-conformal gauge-fermion theories
Not Available
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Infrared fixed point of the SU(3) gauge theory with 𝑁 𝑓 = 10 flavors
We use lattice simulations and the continuous renormalization group method, based on the gradient flow, to calculate the 𝛽 function and anomalous dimensions of the SU(3) gauge theory with 𝑁 𝑓 = 10 flavors of fermions in the fundamental representation. We employ several improvements to extend the range of available renormalized couplings, including the addition of heavy Pauli-Villars bosons to reduce cutoff effects and the combination of a range of gradient flow transformations. While in the weak coupling regime our result is consistent with those of earlier studies, our techniques allow us to study the system at much stronger couplings than previously possible. We find that the renormalization group 𝛽 function develops a zero, corresponding to an infrared-stable fixed point, at gradient-flow coupling 𝑔 2 = 15.0(5). We also determine the mass and tensor anomalous dimensions: At the fixed point we find 𝛾 𝑚 ≃0.6, suggesting that this system might be deep inside the conformal window.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Molecular-dynamics simulation methods for macromolecular crystallography
It is investigated whether molecular-dynamics (MD) simulations can be used to enhance macromolecular crystallography (MX) studies. Historically, protein crystal structures have been described using a single set of atomic coordinates. Because conformational variation is important for protein function, researchers now often build models that contain multiple structures. Methods for building such models can fail, however, in regions where the crystallographic density is difficult to interpret, for example at the protein–solvent interface. To address this limitation, a set of MD–MX methods that combine MD simulations of protein crystals with conventional modeling and refinement tools have been developed. In an application to a cyclic adenosine monophosphate-dependent protein kinase at room temperature, the procedure improved the interpretation of ambiguous density, yielding an alternative water model and a revised protein model including multiple conformations. The revised model provides mechanistic insights into the catalytic and regulatory interactions of the enzyme. The same methods may be used in other MX studies to seek mechanistic insights.
59 BASIC BIOLOGICAL SCIENCES↗
Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population
Highlights: • Screening of 300 CHD patients revealed two rare missense variants (p.P51L & p.D327E) in NODAL. • A novel missense variation p.M345I was identified in ACVR1B. • Bioinformatic analyses suggested that these variants could have deleterious role. • Three-dimensional modelling suggested conformation changes in the mutated proteins compared to wild-type. • In vitro studies demonstrated that missense variants affect the function of NODAL and ACVR1B. NODAL signaling plays an essential role in vertebrate embryonic patterning and heart development. Accumulating evidences suggest that genetic mutations in TGF-β/NODAL signaling pathway can cause congenital heart disease in humans. To investigate the implication of NODAL signaling in isolated cardiovascular malformation, we have screened 300 non-syndromic CHD cases and 200 controls for NODAL and ACVR1B by Sanger sequencing and identified two rare missense (c.152C > T; p.P51L and c.981 T > A; p.D327E) variants in NODAL and a novel missense variant c.1035G > A; p.M345I in ACVR1B. All these variants are absent in 200 controls. Three-dimensional protein-modelling demonstrates that both p.P51L and p.D327E variations of NODAL and p.M345I mutation of ACVR1B, affect the tertiary structure of respective proteins. Variants of NODAL (p.P51L and p.D327E) and ACVR1B (p.M345I), significantly reduce the transactivation of AR3-Luc, (CAGA){sub 12}-Luc and (SBE){sub 4}-Luc promoters. Moreover, qRT-PCR results have also deciphered a reduction in the expression of cardiac-enriched transcription factors namely Gata4, Nkx2-5, and Tbx5 in both the mutants of NODAL. Decreased expression of, Gata4, Nkx2-5, Tbx5, and lefty is observed in p.M345I mutant of ACVR1B as well. Additionally, reduced phosphorylation of SMAD2/3 in response to these variants, suggests impaired NODAL signaling and possibly responsible for defective cell fate decision and differentiation of cardiomyocytes leading to CHD phenotype.
60 APPLIED LIFE SCIENCES↗
Global flow structure and exact formal transseries of the Gubser flow in kinetic theory
In this work we introduce the generic conditions for the existence of a non-equilibrium attractor that is an invariant manifold determined by the long-wavelength modes of the physical system. We investigate the topological properties of the global flow structure of the Gubser flow for the Israel-Stewart theory and a kinetic model for the Boltzmann equation by employing Morse-Smale theory. We present a complete classification of the invariant submanifolds of the flow and determine all the possible flow lines connecting any pair of UV/IR fixed points. The formal transseries solutions to the Gubser dynamical system around the early-time (UV) and late-time (IR) fixed points are constructed and analyzed. It is proven that these solutions are purely perturbative (or power-law asymptotic) series with a finite radius of convergence. Based on these analyses, we find that Gubser-like expanding kinetic systems do not hydrodynamize owing to the failure of the hydrodynamization process which heavily relies on the classification of (non)hydrodynamic modes in the IR regime. This is in contrast to longitudinal boost-invariant plasmas where the asymptotic dynamics is described by a few terms of the hydrodynamic gradient expansion. We finally compare our results for both Bjorken and Gubser conformal kinetic models.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
Phases of $ \mathcal{N} $ = 2 Sachdev-Ye-Kitaev models
We study N = 2 supersymmetric Sachdev-Ye-Kitaev (SYK) models with com- plex fermions at non-zero background charge. Motivated by multi-charge supersymmetric black holes, we propose a new N = 2 SYK model with multiple U(1) symmetries, integer charges, and a non-vanishing supersymmetric index, realizing features not present in known SYK models. In both models, a conformal solution with a super-Schwarzian mode emerges at low temperatures, signaling the appearance of nearly AdS2/BPS physics. However, in contrast to complex SYK, the fermion scaling dimension depends on the background charge in the conformal limit. For a critical charge, we find a high to low entropy phase transition in which the conformal solution ceases to be valid. This transition has a simple interpretation– the fermion scaling dimension violates the unitarity bound. We offer some comments on a holographic interpretation for supersymmetric black holes.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Correction to “Frank–Kasper Phases of Diblock Copolymer Melts Studied with the DPD Model: SCF Results”
In a recent study, (1) we performed the self-consistent field (SCF) calculations of a dissipative particle dynamics (DPD) model of conformationally asymmetric diblock copolymer A-B melts to study the stability of various Frank–Kasper (FK) phases formed by such A-B melts. While all the equations in ref (1) are correct, we did not calculate the dimensionless (mean-field) Helmholtz free energies per chain βf c = βu c,χ + βu c,κ – s c /k B and the dimensionless stresses dβf c /dθ of ordered phases accurately. For example, the dimensionless (nonbonded) internal energy per chain due to the system compressibility βu c,κ = (N/2κ)∑ q βû 0 (|q|)(ϕ̂ A (q) + ϕ̂ B (q) – δ q,0 )(ϕ̂ A (−q) + ϕ̂ B (−q) – δ– q,0 ) should be calculated in the reciprocal space as given (note that βû 0 (|q|) is obtained analytically, and that since ϕ A (r) is real 𝜙̂ A (−𝐪)= $\overline{𝜙̂ A}$(𝐪), i.e., the complex conjugate of ϕ̂ A (q)); this corresponds to numerically evaluating βu c,κ = (N/2κ)∫dr(ϕ A (r) + ϕ B (r) – 1)ψ(r) with ψ(r) ≡ (∫dr′βu 0 (|r–r′|)(ϕ A (r′) + ϕ B (r′) – 1)/V in the real space via the (composite) trapezoidal rule. While the trapezoidal rule is less accurate than the Romberg integration (2) in general, the opposite occurs when the integration domain is periodic; this was pointed out by Matsen in ref (3) and explained in detail in refs (4and5). With our ignorance of this exceptional convergence property of the trapezoidal rule for periodic functions, we calculated all convolutions having the form of ψ(r) in the reciprocal space via the fast Fourier transforms (6) but those having the form of βu c,κ in the real space via Romberg integration; the latter leads to inaccurate results and unfortunately incorrect phase diagrams reported in ref (1), which are corrected here.
He, Juntong↗
Taming lattice artifacts with Pauli-Villars fields
Not Available
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Postquantum Quench Growth of Renyi Entropies in Low-Dimensional Continuum Bosonic Systems
The growth of Renyi entropies after the injection of energy into a correlated system provides a window upon the dynamics of its entanglement properties. Here we develop a simulation scheme by which this growth can be determined in Luttinger liquids systems with arbitrary interactions, even those introducing gaps into the liquid. We apply this scheme to an experimentally relevant quench in the sine-Gordon field theory. While for short times we provide analytic expressions for the growth of the second and third Renyi entropy, to access longer times, we combine our scheme with truncated spectrum methods.
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
Nramp: Deprive and conquer?
Solute carriers 11 (Slc11) evolved from bacterial permease (MntH) to eukaryotic antibacterial defense (Nramp) while continuously mediating proton (H+)-dependent manganese (Mn2+) import. Also, Nramp horizontal gene transfer (HGT) toward bacteria led to mntH polyphyly. Prior demonstration that evolutionary rate-shifts distinguishing Slc11 from outgroup carriers dictate catalytic specificity suggested that resolving Slc11 family tree may provide a function-aware phylogenetic framework. Hence, MntH C (MC) subgroups resulted from HGTs of prototype Nramp (pNs) parologs while archetype Nramp (aNs) correlated with phagocytosis. PHI-Blast based taxonomic profiling confirmed MntH B phylogroup is confined to anaerobic bacteria vs. MntH A (MA)’s broad distribution; suggested niche-related spread of MC subgroups; established that MA-variant MH, which carries ‘eukaryotic signature’ marks, predominates in archaea. Slc11 phylogeny shows MH is sister to Nramp. Site-specific analysis of Slc11 charge network known to interact with the protonmotive force demonstrates sequential rate-shifts that recapitulate Slc11 evolution. 3D mapping of similarly coevolved sites across Slc11 hydrophobic core revealed successive targeting of discrete areas. The data imply that pN HGT could advantage recipient bacteria for H+-dependent Mn2+ acquisition and Alphafold 3D models suggest conformational divergence among MC subgroups. It is proposed that Slc11 originated as a bacterial stress resistance function allowing Mn2+-dependent persistence in conditions adverse for growth, and that archaeal MH could contribute to eukaryogenesis as a Mn2+ sequestering defense perhaps favoring intracellular growth-competent bacteria.
59 BASIC BIOLOGICAL SCIENCES↗
SN 2019yvq Does Not Conform to SN Ia Explosion Models
We present new photometric and spectroscopic observations of SN 2019yvq, a Type Ia supernova (SN Ia) exhibiting several peculiar properties including an excess of UV/optical flux within days of explosion, a high Si ii velocity, and a low peak luminosity. Photometry near the time of first light places new constraints on the rapid rise of the UV/optical flux excess. Furthermore, a near-infrared spectrum at +173 days after maximum light places strict limits on the presence of H or He emission, effectively excluding the presence of a nearby nondegenerate star at the time of explosion. New optical spectra, acquired at +128 and +150 days after maximum light, confirm the presence of [Ca ii] λ7300 and persistent Ca ii NIR triplet emission as SN 2019yvq transitions into the nebular phase. The lack of [O i]$\lambda 6300$ emission disfavors the violent merger of two C/O white dwarfs (WDs) but the merger of a C/O WD with a He WD cannot be excluded. We compare our findings with several models in the literature postulated to explain the early flux excess including double-detonation explosions, 56 Ni mixing into the outer ejecta during ignition, and interaction with H- and He-deficient circumstellar material. Each model may be able to explain both the early flux excess and the nebular [Ca ii] emission, but none of the models can reconcile the high photospheric velocities with the low peak luminosity without introducing new discrepancies.
79 ASTRONOMY AND ASTROPHYSICS↗
Supercooled phase transitions in conformal dark sectors explain NANOGrav data
According to recent lore, it is difficult to explain the evidence for a stochastic gravitational wave background obtained by pulsar timing arrays with supercooled first-order phase transitions (FOPTs). We demonstrate that supercooled FOPTs in dark U(1) models with a conformal dark sector easily explain the nHz signal at NANOGrav.
Conformal models↗
Collider phenomenology of a gluino continuum
Continuum supersymmetry is a class of models in which the supersymmetric partners together with part of the standard model come from a conformal sector, broken in the IR near the TeV scale. Such models not only open new doors for addressing the problems of the standard model, but also have unique signatures at hadron colliders, which might explain why we have not yet seen any superpartners at the LHC. Here we use gauge-gravity duality to model the conformal sector, generate collider simulations, and finally analyze continuum gluino signatures at the LHC. Due to the increase in the number of jets produced the bounds are weaker than for the minimal supersymmetric standard model with the same gluino mass threshold.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Integrating AlphaFold and deep learning for atomistic interpretation of cryo-EM maps
Abstract Interpretation of cryo-electron microscopy (cryo-EM) maps requires building and fitting 3D atomic models of biological molecules. AlphaFold-predicted models generate initial 3D coordinates; however, model inaccuracy and conformational heterogeneity often necessitate labor-intensive manual model building and fitting into cryo-EM maps. In this work, we designed a protein model-building workflow, which combines a deep-learning cryo-EM map feature enhancement tool, CryoFEM (Cryo-EM Feature Enhancement Model) and AlphaFold. A benchmark test using 36 cryo-EM maps shows that CryoFEM achieves state-of-the-art performance in optimizing the Fourier Shell Correlations between the maps and the ground truth models. Furthermore, in a subset of 17 datasets where the initial AlphaFold predictions are less accurate, the workflow significantly improves their model accuracy. Our work demonstrates that the integration of modern deep learning image enhancement and AlphaFold may lead to automated model building and fitting for the atomistic interpretation of cryo-EM maps.
59 BASIC BIOLOGICAL SCIENCES↗
Near conformal perturbation theory in SYK type models
We present a systematic procedure to extract the dynamics of the low energy soft mode in SYK type models with a single energy scale J and emergent reparametrization symmetry in the IR. This is given in the framework of the perturbative scheme of arXiv:1608.07567 based on a specific (off-shell) breaking of conformal invariance in the UV, adjusted to yield the exact large-N saddle point. While this breaking term formally vanishes on-shell, it has a non-trivial effect on correlation functions and the effective action. In particular, it leads to the Schwarzian action with a specific coupling to bi-local matter. The method is applied to the evaluation of O(1) corrections to the correlation function of bi-locals. As a byproduct we confirm precise agreement with the explicit, symmetry breaking procedure. We provide a verification in the large q limit (Liouville theory), where the correlators can be calculated exactly at all length scales. In this case, our scheme illuminates how the enhanced O(J) and the subleading O(1) contributions originate from the Schwarzian dynamics of the soft mode and its interaction with h = 2 (bi-local) matter.
1/N expansion↗
Machine Learning with Gradient-Based Optimization of Nuclear Waste Vitrification with Uncertainties and Constraints
Gekko is an optimization suite in Python that solves optimization problems involving mixed-integer, nonlinear, and differential equations. The purpose of this study is to integrate common Machine Learning (ML) algorithms such as Gaussian Process Regression (GPR), support vector regression (SVR), and artificial neural network (ANN) models into Gekko to solve data based optimization problems. Uncertainty quantification (UQ) is used alongside ML for better decision making. These methods include ensemble methods, model-specific methods, conformal predictions, and the delta method. An optimization problem involving nuclear waste vitrification is presented to demonstrate the benefit of ML in this field. ML models are compared against the current partial quadratic mixture (PQM) model in an optimization problem in Gekko. GPR with conformal uncertainty was chosen as the best substitute model as it had a lower mean squared error of 0.0025 compared to 0.018 and more confidently predicted a higher waste loading of 37.5 wt% compared to 34 wt%. The example problem shows that these tools can be used in similar industry settings where easier use and better performance is needed over classical approaches. Future works with these tools include expanding them with other regression models and UQ methods, and exploration into other optimization problems or dynamic control.
12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗