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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 55 records · Page 3
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NASA NTRS2004

Bioavailability and Pharmacodynamics of Promethazine on Long Duration Missions to the International Space Station

Space motion sickness (SMS) is often treated in space with promethazine (PMZ). Common side effects of PMZ administration (50 mg intramuscular) on the ground are drowsiness and impaired cognitive performance. Anecdotal reports indicate that these effects are absent or less pronounced in space. This suggests that the availability of PMZ to the body (bioavailability) and/or the response of the body to PMZ (pharmacodynamics) may change during space flight. Opportunities for clinical research in space are limited. The study described here is our response to a NASA Research Announcement for proposals for flight-based research needed to improve, or answer specific questions about, diagnosis and therapy during space flight, and post-flight rehabilitation. We propose here to evaluate noninvasive methods for determining the bioavailability and pharmacodynamics of PMZ. The specific objectives of the proposed research are to 1) compare pharmacokinetic and pharmacodynamic parameters of PMZ, estimated from saliva and plasma levels after administration of PMZ, 2) estimate the relative bioavailability of the three dosage forms of PMZ that are often administered to control motion sickness symptoms in space, and 3) establish the dose-response relationship of PMZ. We will estimate the bioavailability of an intramuscular injection (IM), oral tablet, and rectal suppository of PMZ in noma1 subjects during ambulatory and antiorthostatic bed rest (ABR) conditions using novel stable isotope techniques. We will compare and contrast the bioavailability of PMZ during normal and microgravity conditions to examine changes in drug absorption and bioavailability during microgravit. Results of this study will validate methods for an approved in-flight investigation with this medication awaiting an opportunity for manifestation..

Putcha, Lakshmi↗
NASA NTRS2012

Design, Development, Test, and Evaluation of Atmosphere Revitalization and Environmental Monitoring Systems for Long Duration Missions

The Advanced Exploration Systems Program's Atmosphere Resource Recovery and Environmental Monitoring (ARREM) project is working to mature optimum atmosphere revitalization and environmental monitoring system architectures. It is the project's objective to enable exploration beyond Lower Earth Orbit (LEO) and improve affordability by focusing on three primary goals: 1) achieving high reliability, 2) reducing dependence on a ground-based logistics resupply model, and 3) maximizing commonality between atmosphere revitalization subsystem components and those needed to support other exploration elements. The ARREM project's strengths include using existing developmental hardware and testing facilities, when possible, and and a well-coordinated effort among the NASA field centers that contributed to past ARS and EMS technology development projects.

Roman, Monsi C.↗
NASA NTRS2014

ECLSS Reliability for Long Duration Missions Beyond Lower Earth Orbit

Reliability has been highlighted by NASA as critical to future human space exploration particularly in the area of environmental controls and life support systems. The Advanced Exploration Systems (AES) projects have been encouraged to pursue higher reliability components and systems as part of technology development plans. However there is no consensus on what is meant by improving on reliability; nor on how to assess reliability within the AES projects. This became apparent when trying to assess reliability as one of several figures of merit for a regenerable water architecture trade study. In the spring of 2013, the AES Water Recovery Project (WRP) hosted a series of events at the NASA Johnson Space Center (JSC) with the intended goal of establishing a common language and understanding of our reliability goals, and equipping the projects with acceptable means of assessing our respective systems. This campaign included an educational series in which experts from across the agency and academia provided information on terminology, tools and techniques associated with evalauating and designing for system reliability. The campaign culminated in a workshop at JSC with members of the ECLSS and AES communities with the goal of developing a consensus on what reliability means to AES and identifying methods for assessing our low to mid-technology readiness level (TRL) technologies for reliability. This paper details the results of the workshop.

Sargusingh, Miriam J.↗
NASA NTRS2014

Environmental Control and Life Support System Reliability for Long-Duration Missions Beyond Lower Earth Orbit

NASA has highlighted reliability as critical to future human space exploration, particularly in the area of environmental controls and life support systems. The Advanced Exploration Systems (AES) projects have been encouraged to pursue higher reliability components and systems as part of technology development plans. However, no consensus has been reached on what is meant by improving on reliability, or on how to assess reliability within the AES projects. This became apparent when trying to assess reliability as one of several figures of merit for a regenerable water architecture trade study. In the spring of 2013, the AES Water Recovery Project hosted a series of events at Johnson Space Center with the intended goal of establishing a common language and understanding of NASA's reliability goals, and equipping the projects with acceptable means of assessing the respective systems. This campaign included an educational series in which experts from across the agency and academia provided information on terminology, tools, and techniques associated with evaluating and designing for system reliability. The campaign culminated in a workshop that included members of the Environmental Control and Life Support System and AES communities. The goal of this workshop was to develop a consensus on what reliability means to AES and identify methods for assessing low- to mid-technology readiness level technologies for reliability. This paper details the results of that workshop.

Sargusingh, Miriam J.↗
NASA NTRS2014

ECLSS Reliability for Long Duration Missions Beyond Lower Earth Orbit

Reliability has been highlighted by NASA as critical to future human space exploration particularly in the area of environmental controls and life support systems. The Advanced Exploration Systems (AES) projects have been encouraged to pursue higher reliability components and systems as part of technology development plans. However, there is no consensus on what is meant by improving on reliability; nor on how to assess reliability within the AES projects. This became apparent when trying to assess reliability as one of several figures of merit for a regenerable water architecture trade study. In the Spring of 2013, the AES Water Recovery Project (WRP) hosted a series of events at the NASA Johnson Space Center (JSC) with the intended goal of establishing a common language and understanding of our reliability goals and equipping the projects with acceptable means of assessing our respective systems. This campaign included an educational series in which experts from across the agency and academia provided information on terminology, tools and techniques associated with evaluating and designing for system reliability. The campaign culminated in a workshop at JSC with members of the ECLSS and AES communities with the goal of developing a consensus on what reliability means to AES and identifying methods for assessing our low to mid-technology readiness level (TRL) technologies for reliability. This paper details the results of the workshop.

Sargusingh, Miriam J.↗
NASA NTRS2017

Getting Out of Orbit: Water Recycling Requirements and Technology Needs for Long Duration Missions Away from Earth

Deep-space crewed missions will not have regular access to the Earth's resources or the ability to rapidly return to Earth if a system fails. As crewed missions extend farther from Earth for longer periods, habitation systems must become more self-sufficient and reliable for safe, healthy, and sustainable human exploration. For human missions to Mars, Environmental Control and Life Support Systems (ECLSS) must be able operate for up to 1,100 days with minimal spares and consumables. These missions will require capabilities to more fully recycle atmospheric gases and wastewater to substantially reduce mission costs. Even with relatively austere requirements for use, water represents one of the largest consumables by mass. Systems must be available to extract and recycle water from all sources of waste. And given that there will be no opportunity to send samples back to Earth for analysis, analytical measurements will be limited to monitoring hardware brought on board the spacecraft. The Earth Reliant phase of NASA's exploration strategy includes leveraging the International Space Station (ISS) to demonstrate advanced capabilities for a robust and reliable ECLSS. The ISS Water Recovery System (WRS) includes a Urine Processor Assembly (UPA) for distillation and recovery of water from urine and a Water Processor Assembly (WPA) to process humidity condensate and urine distillate into potable water. Possible enhancements to more fully "close the water loop" include recovery of water from waste brines and solid wastes. A possible game changer is the recovery of water from local planetary resources through use of In Situ Resource Utilization (ISRU) technologies. As part of the development and demonstration sequence, NASA intends to utilize cis-Lunar space as a Proving Ground to verify systems for deep space habitation by conducting extended duration missions to validate our readiness for Mars.

Barta, Daniel J.↗
NASA NTRS2019

Astronaut Mass Balance for Long Duration Missions

Human spaceflight logistics requirements are strongly driven by the daily living needs of the astronauts, including their biological functions. Oxygen, water and food are absolute requirements to sustain life and must be supplied at adequate rates. However, these rates can vary from day to day and from person to person. Beyond the body's immediate physical needs, water is also required for important health and hygiene functions within the spacecraft. Undesirable weight loss or gain aside, human waste product mass outputs will equal the inputs over time, resulting in an average astronaut mass balance. Best values, as well as range of variability for inputs and outputs are explored at both the individual physiological level and the spacecraft level. These values are important for design of life support and habitability systems as well as for mission planning of consumables. Current spacecraft life support systems are not fully closed loop, but the International Space Station (ISS) does recycle most of its air and water. The astronaut mass balances at the personal and vehicle level can have different impacts at different levels of system closure. Recommendations are made for a consistent set of values representing a realistic average astronaut mass balance over reasonable durations for exploration missions.

Ewert, Michael K.↗
NASA NTRS2022

Regenerative Life Support Systems for Exploration Habitats: Unique Capabilities and Challenges to Enable Long-Duration-Mission Habitats Beyond Low Earth Orbit

The Artemis I launch of NASA’s Space Launch System and Orion crew vehicle will mark a major milestone in the agency’s efforts to return humans to the Moon. Work is underway on the Human Landing System that will carry the next astronauts to the lunar surface, and the lunar orbiting Gateway that will host science and serve as a platform to support sustained human presence on the Moon and ultimately crewed missions to Mars. Two decades of continuous human presence on the International Space Station has provided a wealth of experience operating, upgrading, and demonstrating advanced Regenerative Environmental Control and Life Support Systems (Regen ECLSS). However, habitats that enable sustained lunar surface presence and transit to Mars will encounter many unique conditions and challenges. System characteristics including reliability, maintainability, mass, and power become significantly more critical. Operating environments associated with lower total pressure, low gravity, contingency protocols, and extensive un-crewed and dormant periods impose additional functionality requirements and alter the performance of certain critical systems. Integration and combined operations with other elements such as orbiting outposts, logistics suppliers, and mobility platforms impact capability and interface requirements. Limits on allocated water and oxygen consumable mass influence the need for higher levels of water and oxygen recovery from waste products. Impacts and challenges these unique exploration circumstances impose on the suite of Regen ECLSS systems are explored and discussed herein.

David F Howard↗
NASA NTRSDate not supplied

Comparison Between Continuous and Intermittent Actigraphy Outcomes During Long-Duration Missions

INTRODUCTION Historically, astronauts have worn actigraphy watches continuously throughout their missions. This has enabled reliable sleep estimation and comparisons between sleep and other outcomes and mission activities such as the arrival of a visiting vehicle. However in late 2020, astronauts were scheduled to wear an actiwatch for one 2-week period every two months, substantially decreasing availability of data. Our aim was to compare sleep and mission events between data collected continuously and data collected intermittently to identify any differences. METHODS Crewmembers (n = 19) who volunteered for the NASA Standard Measures protocol between January 2019 and March 2022 were provided with actiwatches (Phillips, Respironics, Bend OR) that they wore either continuously (C; n = 9) or for two weeks every two months while in space (2W; n = 10). We used crew schedules to identify mission events that were asynchronous with actigraphy. We further compared sleep outcomes (sleep duration, wake after sleep onset [WASO], sleep efficiency) between the C and 2W actigraphy collection. RESULTS In the 2W group, sleep data was not available for 52% of EVAs, 67% of visiting vehicle events, and 67% of commander turnovers. Average sleep duration for the 2W group (M = 6.91, ± 1.24 SD) was significantly lower compared to the C group (7.51 ± 1.08, p < .01). Sleep efficiency was better for those in the C group (90.56 ± 5.19) than for those in the 2W group (87.02 ± 6.47 p < .01). There were no significant differences in WASO (C = 26.66 ±12.99; 2W = 32.38 ± 18.83). DISCUSSION Continuous actigraphy data collection yields different sleep outcomes compared to intermittent data collection. In addition, many mission events were not captured with intermittent data collection. Our findings support the use of continuous actigraphy data collection.

fatigue↗
NASA NTRSDate not supplied

Low Leakage Valves for Long Duration Missions

This paper presents a status update on the low leakage cryogenic test valves currently under development at NASA’s Marshall Space Flight Center. These valves consist of a 3-inch isolation valve, a 3-inch relief valve, and an 8-inch pre-valve. Each of these valves contain a self-aligning seat and poppet design to significantly reduce the quantity of propellant flowing past the seat when the valve is in its closed state (internal leakage). This self-aligning design utilizes a metallic poppet head with five degrees of freedom and is intended to allow a valve to be more tolerant of the imperfect contacts and misalignments that are commonly found between sealing surfaces. This paper covers the test articles, facilities, objectives, and preliminary results.

Cryogenic Fluid Management↗
NASA NTRS2023

Low Leakage Valves for Long Duration Missions

This paper presents a status update on the low leakage cryogenic test valves currently under development at NASA’s Marshall Space Flight Center. These valves consist of a 3-inch isolation valve, a 3-inch relief valve, and an 8-inch pre-valve. Each of these valves contain a self-aligning seat and poppet design to significantly reduce the quantity of propellant flowing past the seat when the valve is in its closed state (internal leakage). This self-aligning design utilizes a metallic poppet head with five degrees of freedom and is intended to allow a valve to be more tolerant of the imperfect contacts and misalignments that are commonly found between sealing surfaces. This paper covers the test articles, facilities, objectives, and preliminary results.

Cryogenic Fluid Management↗
NASA NTRSDate not supplied

Comparison Between Continuous and Intermittent Actigraphy Outcomes During Long Duration Missions

Astronauts typically wear actigraphy watches continuously during their missions inflight. In late 2020, astronauts were scheduled to wear an actiwatch for one 2-week period every two months. Our aim was to compare sleep outcomes between data collected continuously vs intermittently to identify whether intermittently collected sleep data would yield similar results.

fatigue↗