Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations
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Open Charge Point Protocol (OCPP) 1.6 is widely used in the electric vehicle (EV) charging industry to communicate between Charging System Management Services (CSMSs) and Electric Vehicle Supply Equipment (EVSE). Unlike OCPP 2.0.1, OCPP 1.6 uses unencrypted websocket communications to exchange information between EVSE devices and an onpremise or cloud-based CSMS. In this work, we demonstrate two machine-in-the-middle (MITM) attacks on OCPP sessions to terminate charging sessions and gain root access to the EVSE equipment via remote code execution (RCE). Second, we demonstrate a malicious firmware update with a code injection payload to compromise an EVSE. Lastly, we demonstrate two methods to prevent availability of the EVSE or CSMS. One of these, originally reported by SaiFlow, prevents traffic to legitimate EVSE equipment using a DoS-like attack on CSMSs by repeatedly connecting and authenticating several CPs with the same identities as the legitimate CP. These vulnerabilities were demonstrated with proof-of-concept exploits in a virtualized Cyber Range at Wright State University and/or with a 350 kW Direct Current Fast Charger (DCFC) at Idaho National Laboratory. The team found that OCPP 1.6 could be protected from these attacks by adding secure shell (SSH) tunnels to the protocol, if upgrading to OCPP 2.0.1 was not an option. Index Terms—Electric vehicle charging, cybersecurity, OCPP, cyberattack, cyber-resilience. INSPEC Accession Number: 23981565
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We present results of a spectroscopic campaign around the diffuse dwarf galaxy Crater 2 (Cra2) and its tidal tails as part of the Southern Stellar Stream Spectroscopic Survey ($S^5$). Cra2 is a Milky Way dwarf spheroidal satellite with extremely cold kinematics, but a huge size similar to the Small Magellanic Cloud, which may be difficult to explain within collisionless cold dark matter. We identify 143 Cra2 members, of which 114 belong to the galaxy's main body and 29 are deemed part of its stellar stream. We confirm that Cra2 is dynamically cold (central velocity dispersion $2.51^{+0.33}_{-0.30}\,{\rm km\,s^{-1}}$) and also discover a $\approx$7$Ï$ velocity gradient consistent with its tidal debris track. We separately estimate the stream velocity dispersion to be $5.74^{+0.98}_{-0.83}\,{\rm km\,s^{-1}}$. We develop a suite of $N$-body simulations with both cuspy and cored density profiles on a realistic Cra2 orbit to compare with $S^5$ observations. We find that the velocity dispersion ratio between Cra2 stream and galaxy ($2.30^{+0.41}_{-0.35}$) is difficult to reconcile with a cuspy halo with fiducial concentration and an initial mass predicted by standard stellar mass$-$halo mass relationships. Instead, either a cored halo with relatively small core radius or a low-concentration cuspy model can reproduce this ratio. Despite tidal mass loss, Cra2 is metal-poor ($\langle \rm[Fe/H]\rangle=-2.16\pm0.04$) compared to the stellar mass$-$metallicity relation for its luminosity. Other diffuse dwarf galaxies similar to Cra2 in the Local Group (Antlia 2 and Andromeda 19) also challenge galaxy formation models. Finally, we discuss possible formation scenarios for Cra2, including ram-pressure stripping of a gas-rich progenitor combined with tides.
ISSCC paper on nanoprober
The Center for Tokamak Transients Simulations (CTTS) consists of computational plasma physicists, computer scientists, and applied mathematicians who are together developing and applying simulation software to improve our understanding of and ability to predict and control transient events in tokamak discharges, particularly those that lead to violent disruptions. We have major simulation activities concerning disruptions that are caused by violating ideal MHD stability criteria, vertical displacement events, resistive wall modes, and tearing modes. We are performing comprehensive modeling of disruption mitigation techniques, particularly by shattered pellet injection (SPI). The Center is built around two mature extended MHD codes: NIMROD and M3D-C1. These codes are being extended in a number of ways as required by the demands of disruption modeling, and are being optimized to work well for larger problem size and modern computer architectures as required to model tokamak plasmas with realistic parameters over the required timescales. The codes will be coupled to the FronTier code for state-of-the-art modeling of SPI. Validation with experimental data on DIII-D, NSTX, and JET is being facilitated by rigorous uncertainty quantification (UQ). The high-level objectives of the center are to: (1) Develop better understanding and improved predictive capability of when crossing a linear stability boundary will likely lead to a disruption, (2) Provide a tool for calculating vessel forces, both axisymmetric and non-axisymmetric, for worst case VDE and other disruptions in tokamaks, (3) Develop increased understanding and improved predictive capability for locked mode disruptions and how best to avoid them, (4) Develop, verify, and validate 3D models for disruption mitigation by shattered pellets that can be used to design and optimize a system for future tokamaks, and (5) Increase the efficiency and scalability of the M3D-C1 and NIMROD codes so that they can model disruptions in ITER scale devices using the most powerful DOE HPC hardware, and (6) Demonstrate code-coupling via FronTier coupling with NIMROD and M3D-C1 and by interfacing these codes within a WDM framework.
The National Spherical Torus Experiment Upgrade (NSTX-U) centerstack casing surrounds the central magnet core of NSTXU. It provides the inner vacuum boundary of the plasma chamber and supports the radially inboard plasma facing components lining the plasma chamber. The casing is supported like a cantilever, fixed at the lower flange by a connection to the TF Bundle through a G-10 ring. It is flexibly supported at the top by bellows, and insulated shims intended to react the largest part of the inventory of the disruption loads at the upper support, thereby protecting the upper and lower connections from excessive loads. A large part of the qualification of the casing and tiles requires addressing and quantifying disruption loads. These have been estimated based on extensions of the behavior of NSTX during its run period roughly 15 years ago. Structural qualification of the Upgrade used these estimates of the loading as input to calculations to demonstrate adequacy for a “most probable” disruption. The estimates are included in a requirements document to guide conservative design of all components loaded by disruptions. However, the changes made for the upgrade made the extrapolation of disruption behavior uncertain. Disruptions include axisymmetric loading from axisymmetric currents induced in the vessel shells. In addition, more complex currents called Halo currents are a result of plasma poloidal currents impinging on the casing. The halo currents add another layer of uncertain behavior and net lateral loading to the casing. As a result, NSTX-U is equipped with a number of instruments intended to assess the nature and severity of disruptions. The casing shims are required for lateral support of the casing, but these have also been converted to load cells to provide another measure of the magnitude of symmetric and asymmetric loading. Some of the logic in the development of the requirements document are presented. Electromagnetic analysis of axisymmetric and halo loading is described. Global simulations of the casing transient dynamic response, and local analysis and testing of the shim/load cell are included. The shim load cells and other instrumentation will be an important guide in planning NSTX-U experiments beyond its next run period expected in late 2026 or early 2027.
This paper reports the multisatellite and ground observations of two pseudo-substorm onset events that occurred successively at 0747 UT and 0811 UT, May 30, 1985, with more attention to the 0747 UT onset. The distinguishing features of the 0747 UT event are as follows. (1) The substorm-associated tail reconfiguration started in a very localized region in the near-Earth magnetotail. (2) The magnitude of the current disruption decreased markedly as the disruption region expanded tailward. (3) On the ground the onset of a very small negative bay (approx. 40 nT) was observed simultaneously with the onset of the current disruption, but over a much wider local time sector than the near-Earth tail reconfiguration. Positive bay onsets at mid-latitudes also had a longitudinally wide distribution. From these features we infer than in the present event the current disruption took place filamentarily near AMPTE/CCE at approx. 8.8 R(sub E). It is also inferred that pseudo-substorm onsets are distinguished from standard substorm onsets by the absence of a global expansion of the current disruption, and that the spatial scales of the onset region in the magnetosphere is not a major difference between the two. The present study suggests that the spatial distribution of the magnetic distortion before onsets is an important factor to determine the expansion scale of the current disruption. It is also suggested that the current disruption is basically an internal process of the magnetosphere.
OBJECTIVE: To concisely review the field of cell plasma membrane disruption (torn cell surface) and repair. MAIN POINTS: Plasma membrane disruption is a common form of cell injury under physiologic conditions, after trauma, in certain muscular dystrophies, and during certain forms of clinical intervention. Rapid repair of a disruption is essential to cell survival and involves a complex and active cell response that includes membrane fusion and cytoskeletal activation. Tissues, such as cardiac and skeletal muscle, adapt to a disruption injury by hypertrophying. Cells adapt by increasing the efficiency of their resealing response. CONCLUSION: Plasma membrane disruption is an important cellular event in both health and disease. The disruption repair mechanism is now well understood at the cellular level, but much remains to be learned at the molecular level. Cell and tissue level adaptational responses to the disruption either prevent its further occurrence or facilitate future repairs. Therapeutically useful drugs might result if, using this accumulating knowledge, chemical agents can be developed that can enhance repair or adaptive responses.
This is the final report for the early career award for Prof. Egemen Kolemen that aimed to develop the physics and technical basis of real-time transient – i.e. disruptions and Edge Localized Modes (ELMs) – avoidance and feedback control at the DIII-D nuclear fusion facility for the ITER era. During this project, we reconstructed high quality real-time DIII-D equilibria using kinetic information from the motional Stark effect (MSE), Thomson Scattering (TS), and Charge Exchange Recombination (CER) spectroscopy. These equilibria were analyzed in real-time to determine the low-n ideal MHD stability and the pedestal stability thresholds, and to obtain plasma response models. These calculations were used to understand which physical process evolves to lead to the onset of disruption in ITER-relevant scenarios at DIII-D, and how disruption can be predicted using stability analysis as opposed to the current methods of correlation of various signals, which are descriptive but lack predictive power. In the disruption studies, we focused on tearing modes, since these constitute the vast majority of disruptions in this regime. With this knowledge, real-time disruption avoidance algorithms were developed and tested. The enhanced situation awareness and physics insight were used in advanced real-time feedback control of pedestal and core profiles, which allowed the pursuit and sustainment of transient-free high-confinement regimes that cannot be achieved via feed-forward design based on in-between shot analysis.