Search NASA⌕ Search

SEARCH · Search NASA

Results for “Accelerated Life Testing”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 793 records · Page 44

SU-F-T-305: Clinical Effects of Dosimetric Leaf Gap (DLG) Values Between Matched Varian Truebeam (TB) Linacs

Purpose: The dosimetric leaf gap (DLG) is an important parameter to be measured for dynamic beam delivery of modern linacs, like the Varian Truebeam (TB). The clinical effects of DLG-values on IMRT and/or VMAT commissioning of two “matched” TB linacs will be presented.Methods and Materials: The DLG values on two TB linacs were measured for all energy modalities (filtered and FFF-modes) as part of the dynamic delivery mode commissioning (IMRT and/or VMAT. After the standard beam data was modeled in eclipse treatment planning system (TPS) and validated, IMRT validation was performed based on TG1191 benchmark, IROC Head-Neck (H&N) phantom and sample of clinical cases, all measured on both linacs. Although there was a single-set of data entered in the TPS, a noticeable difference was observed for the DLG-values between the linacs. The TG119, IROC phantom and selected patient plans were furnished with DLG-values of TB1 for both linacs and the delivery was performed on both TB linacs for comparison. Results: The DLG values of TB1 was first used for both linacs to perform the testing comparisons. The QA comparison of TG119 plans revealed a great dependence of the results to the DLG-values used for the linac for all energy modalities studied, especially when moving from 3%/3mm to 2%/2mm γ-analysis. Conclusion: The DLG-values have a definite influence on the dynamic dose, delivery that increases with the plan complexity. We recommend that the measured DLG-values are assigned to each of the “matched” linacs, even if a single set of beam data describes multiple linacs. The user should perform a detail test of the dynamic delivery of each linac based on end-to-end benchmark suites like TG119 and IROC phantoms.1Ezzel G., et al., “IMRT commissioning: Multiple institution planning and dosimetry comparisons, a report from AAPM Task Group 119.” Med. Phys. 36:5359–5373 (2009). partly supported by CAMC Cancer Center and Alliance Oncology.

60 APPLIED LIFE SCIENCES↗

Evaluation of Low-cost, Full HD, CMOS Cameras for Use in the Calcine Retrieval Project - 19530

This paper describes results from radiation testing conducted on low-cost, commercial off-the-shelf, full high-definition (HD) resolution (1920 x 1080 p), complementary metal-oxide-semiconductor (CMOS) camera sensors. The purpose of the testing was to evaluate the sensors' suitability for use in the Calcine Retrieval Project by determining their image quality and life expectancy while operating in an ionizing radiation field of 20.0 Gy/h. The two camera sensors tested were the Axis FA1105 and Axis FA1125. These commercial camera sensors were designed for retail security surveillance and have no radiation-hardened (rad-hard) components. In addition to radiation testing, the sensors' field-of-view, resolution, and low-light image quality were tested at several target distances to ensure they meet project requirements. Testing was divided into two phases. During Phase 1, four FA1105 sensors and four FA1125 sensors were tested simultaneously without any shielding in radiation fields of 25.5 Gy/h and 49.3 Gy/h. In Phase 2, three FA1105 and five FA1125 sensors were shielded by 22.2 mm of lead and tested simultaneously in radiation fields of 26.8 Gy/h, 52.3 Gy/h, 143.0 Gy/h, 200.7 Gy/h, 404.6 Gy/h, and 2,317.5 Gy/h. Dose rate values were established using film dosimetry readings. Apertures in the shielding allowed for a 40-degree field of view while shielding all parts of the sensor except for directly in front of the CMOS sensor array. All testing was conducted at the Idaho Accelerator Center in Pocatello, Idaho, using a 450 keV X-ray generator. Sensor images were automatically captured at regular intervals throughout the testing for qualitative evaluation by the test team. Film dosimetry was placed near the sensors to record actual dose totals. The 450 keV setting generates X-ray radiation with an energy level close to the primary gamma energy level produced by the Cesium-137 isotope in the calcine, which is 662 keV. Results from Phase 1 indicate the sensors failed at an average cumulative dose of 226.3 Gy. For a given 20.0 Gy/h field this results in a mean time to failure (MTTF) of 11.3 hours. Recorded images from all sensors showed minimal image degradation due to radiation-induced noise. When the sensors finally failed, the failure mode was an abrupt loss of video. The image went black suggesting some other component in the sensor head besides the CMOS sensor array was responsible for the failure. During a portion of Phase 1 testing, a commercial, rad-hard camera was irradiated in the 25.5 Gy/h field along with the eight Axis FA series sensors. Image quality from the FA series sensors significantly outperformed the image quality of the rad-hard camera in radiation-induced noise tolerance, image resolution, and dynamic range. During Phase 2 testing, all sensors produced excellent images in radiation fields as high as 404.6 Gy/h. One FA1125 sensor was tested at the highest dose rate of 2,317.5 Gy/h. At this dose rate, the image was color shifted towards red and contained a significant amount radiation-induced noise. The sensor did not fail and was producing usable imagery after one hour, at which time the test was ended due to allotted beam-time at the test facility. Eighteen hours after X-rays were shut off, the sensor image returned to normal color and all eight sensors continued to operate without any visible, permanent image degradation. For Phase 2 testing, it was not possible to establish a MTTF since none of the shielded sensors failed during the allotted test time. However, given the highest cumulative dose of 4,142.1 Gy received by a shielded FA1125 sensor, a minimum life expectancy of 207 hours (8.6 days) is predicted while operating in a 20.0 Gy/h field. Test results indicate the radiation tolerance of the FA series sensor's CMOS array, along with the small form factor, full HD image quality, wide dynamic range, and Ethernet standard makes it suitable for short-term use in monitoring and visually documenting waste remediation efforts for the Calcine Retrieval Project at the INL. The sensor's low-cost of about $140 US, compared to commercial rad-hard cameras costing between $5,000 and $7,000 US each, allow them to be used as an affordable, disposable resource for many short-duration, radioactive waste remediation efforts where decontamination of an expensive, commercial rad-hard camera is undesirable or not possible. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Energy Justice Framework for Marine Energy: Considerations from PacWave

To accelerate the energy transition while addressing land use conflicts and community opposition, federal policies and incentives require that new energy infrastructure provide direct benefits to communities, and ensure that these benefits remain in the community. The objective of this study is to develop a framework for collecting demographic, socioeconomic, and environmental data and supporting communities in understanding how such data can support more just and equitable outcomes. Specifically, this study addresses two research questions: (1) How can energy justice be incorporated into ME project life cycle, and (2) what social and economic data are needed to assess how marine energy development supports energy justice? Based on our literature review and the data collection template, a case study of PacWave, a wave energy testing facility located on the central Oregon Coast, is employed to draw more specific implications for how energy justice can be integrated into marine energy. PacWave represents a flagship investment by Oregon State University, the State of Oregon, and the Department of Energy. The facility is situated in Lincoln County, which is home to the Confederated Tribes of Siletz Indians and family-scale fishing enterprises. PacWave has strong community support as a testing site and holds potential to provide valuable lessons for other communities.

16 TIDAL AND WAVE POWER↗

NASA's Evolutionary Xenon Thruster (NEXT) Project Qualification Propellant Throughput Milestone: Performance, Erosion, and Thruster Service Life Prediction After 450 kg

The NASA s Evolutionary Xenon Thruster (NEXT) program is tasked with significantly improving and extending the capabilities of current state-of-the-art NSTAR thruster. The service life capability of the NEXT ion thruster is being assessed by thruster wear test and life-modeling of critical thruster components, such as the ion optics and cathodes. The NEXT Long-Duration Test (LDT) was initiated to validate and qualify the NEXT thruster propellant throughput capability. The NEXT thruster completed the primary goal of the LDT; namely to demonstrate the project qualification throughput of 450 kg by the end of calendar year 2009. The NEXT LDT has demonstrated 28,500 hr of operation and processed 466 kg of xenon throughput--more than double the throughput demonstrated by the NSTAR flight-spare. Thruster performance changes have been consistent with a priori predictions. Thruster erosion has been minimal and consistent with the thruster service life assessment, which predicts the first failure mode at greater than 750 kg throughput. The life-limiting failure mode for NEXT is predicted to be loss of structural integrity of the accelerator grid due to erosion by charge-exchange ions.

Herman, Daniel A.↗

NESC Ceramic Oxygen Generator (COG) Technology Development

The NASA Engineering and Safety Center (NESC) sponsored a project to accelerate the pace of technology development of a ceramic oxygen generator (COG), for NASA and COVID related medical use. NASA applications for this technology include spacesuit oxygen tank recharge, medical applications include providing medical oxygen in remote and low resource settings. During this project, five full-scale (i.e., 30 wafer) cell stacks were built and tested in prototype systems capable of producing pressurized oxygen. System testing measured oxygen product purity, delivery pressure, production rate, and energy use. This report describes ion transport membrane mechanisms, cell stack configuration, and test results.

Oxygen↗

Development of a novel ArcCHECK{sup Trade-Mark-Sign} insert for routine quality assurance of VMAT delivery including dose calculation with inhomogeneities

Purpose: To design a versatile, nonhomogeneous insert for the dose verification phantom ArcCHECK{sup Trade-Mark-Sign} (Sun Nuclear Corp., FL) and to demonstrate its usefulness for the verification of dose distributions in inhomogeneous media. As an example, we demonstrate it can be used clinically for routine quality assurance of two volumetric modulated arc therapy (VMAT) systems for lung stereotactic body radiation therapy (SBRT): SmartArc{sup Registered-Sign} (Pinnacle{sup 3}, Philips Radiation Oncology Systems, Fitchburg, WI) and RapidArc{sup Registered-Sign} (Eclipse{sup Trade-Mark-Sign }, Varian Medical Systems, Palo Alto, CA). Methods: The cylindrical detector array ArcCHECK{sup Trade-Mark-Sign} has a retractable homogeneous acrylic insert. In this work, we designed and manufactured a customized heterogeneous insert with densities that simulate soft tissue, lung, bone, and air. The insert offers several possible heterogeneity configurations and multiple locations for point dose measurements. SmartArc{sup Registered-Sign} and RapidArc{sup Registered-Sign} plans for lung SBRT were generated and copied to ArcCHECK{sup Trade-Mark-Sign} for each inhomogeneity configuration. Dose delivery was done on a Varian 2100 ix linac. The evaluation of dose distributions was based on gamma analysis of the diode measurements and point doses measurements at different positions near the inhomogeneities. Results: The insert was successfully manufactured and tested with different measurements of VMAT plans. Dose distributions measured with the homogeneous insert showed gamma passing rates similar to our clinical results ({approx}99%) for both treatment-planning systems. Using nonhomogeneous inserts decreased the passing rates by up to 3.6% in the examples studied. Overall, SmartArc{sup Registered-Sign} plans showed better gamma passing rates for nonhomogeneous measurements. The discrepancy between calculated and measured point doses was increased up to 6.5% for the nonhomogeneous insert depending on the inhomogeneity configuration and measurement location. SmartArc{sup Registered-Sign} and RapidArc{sup Registered-Sign} plans had similar plan quality but RapidArc{sup Registered-Sign} plans had significantly higher monitor units (up to 70%). Conclusions: A versatile, nonhomogeneous insert was developed for ArcCHECK{sup Trade-Mark-Sign} for an easy and quick evaluation of dose calculations with nonhomogeneous media and for comparison of different treatment planning systems. The device was tested for SmartArc{sup Registered-Sign} and RapidArc{sup Registered-Sign} plans for lung SBRT, showing the uncertainties of dose calculations with inhomogeneities. The new insert combines the convenience of the ArcCHECK{sup Trade-Mark-Sign} and the possibility of assessing dose distributions in inhomogeneous media.

60 APPLIED LIFE SCIENCES↗

Degradation in photovoltaic encapsulant transmittance: Results of the first PVQAT TG5 artificial weathering study

Reduced optical transmittance of encapsulants resulting from ultraviolet (UV) degradation is frequently identified as a cause of decreased performance through the service life of photovoltaic modules. However, the present module safety and qualification standards apply short UV doses, only capable of examining design robustness and 'infant mortality' failures. Furthermore, essential information remains unknown that might be used to screen encapsulants through product lifetime. We conducted an interlaboratory study to provide the understanding that will be used toward developing a higher-fidelity, more-rigorous UV weathering test. Five representative known formulations of poly (ethylene-co-vinyl acetate) were studied, in addition to one thermoplastic polyurethane material. Replicate laminated silica/polymer/silica specimens were examined at seven institutions using a variety of indoor chambers (including xenon, UVA-340, and metal-halide light sources). Specimens were artificially weathered for 180 cumulative days at steady-state accelerated test conditions, predesignated relative to the default irradiance of 1.0 W m-2 nm-1 at 340 nm, chamber temperature of 60 degrees C, and chamber relative humidity of 30%. The solar-weighted transmittance, yellowness index, and the UV cut-off wavelength - each determined from the measured hemispherical transmittance - are examined to provide understanding and guidance for the UV light source (type lamp and filters), temperature, and humidity used in accelerated UV aging tests. The relative efficacy of xenon-arc and UVA-340 fluorescent sources and the typical range of activation energy for degradation is quantified from the experiments.

14 SOLAR ENERGY↗

Cohesive and adhesive degradation in PET-based photovoltaic backsheets subjected to ultraviolet accelerated weathering

Delamination between layers in photovoltaic (PV) backsheets is often reported in the literature, causing voids that can collect moisture, diminish module backside heat dissipation, and reduce the backsheet’s effectiveness as a physical barrier. While backsheets with weathering-resistant fluoropolymer outer layers have traditionally been used in modules, more recent backsheets using non-fluoropolymer outer layers, such as polyethylene terephthalate (PET), have been developed. These backsheets have shown signs of premature degradation, and their adhesion degradation, in particular, has not been widely studied. In the present work, the single cantilever beam (SCB) adhesion test was used to quantify the adhesion energy in two commercially available PET-based backsheets. To study the effect of minor changes in formulation, the backsheets were obtained from same manufacturer and product line but during different years. To study the effect of environmental variables on adhesion degradation, the backsheets were subjected to artificial weathering at controlled temperature, humidity, and ultraviolet (UV) radiation in an indoor weathering chamber, and the adhesion energy was quantified at several intervals of exposure time. Layering structure, composition, and adhesion failure mode were compared between the backsheets, using Raman and infrared spectroscopy and thermogravimetric analysis. The results show a large difference in initial (unexposed) adhesion energy between the backsheets, despite very similar structures and compositions. Following exposure, adhesion energy dropped significantly, primarily due to thermo-hydrolytic degradation of the polyurethane (PU)-based adhesive layers. Significant UV-induced adhesion degradation of the PET outer layer surface was also observed. The study represents an important step in understanding adhesion degradation in PET-based backsheets, suggesting ways in which adhesion integrity – and, correspondingly, module service life – can be improved.

14 SOLAR ENERGY↗

Calculation of collisionless pitch-angle scattering of runaway electrons with synchrotron radiation via high-order guiding-centre equation

Recently, the collisionless pitch-angle scattering for relativistic runaway electrons (REs) in toroidal geometries such as tokamaks was discovered through a full orbit simulation approach (Liu et al., Nucl. Fusion, vol. 56, 2016, p. 064002), and it was then theoretically investigated that a new expression for the magnetic moment, including the second-order corrections, could essentially reproduce the so-called collisionless pitch-angle scattering process (Liu et al., Nucl. Fusion, vol. 58, 2018, p. 106018). In this paper, with synchrotron radiation, extensive numerical verification of the validity of the high-order guiding-centre theory is given for simulations involving REs by incorporating such an expression for the magnetic moment into our particle tracing code. A high-order guiding-centre simulation approach with synchrotron radiation (HGSA) is applied. Synchrotron radiation plays an essential role in the life cycle of REs. The energy of REs first increases and then becomes saturated until the electric field acceleration is balanced by the radiation dissipation. Unfortunately, the process cannot be simulated accurately with the standard guiding-centre model, i.e. the first-order guiding-centre model. Remarkably, it is found that the HGSA can effectively produce the fundamental process of REs. Since the time scale of the energy saturation of REs is close to seconds, the computational cost becomes significant. In order to save costs, it is necessary to estimate the time of energy saturation. An analytical estimate is derived for the time it takes for synchrotron drag to balance an accelerating electric field and the provided formula has been numerically verified. Finally, test calculations reveal that HGSA is favourable for exploiting the dynamics of REs in tokamak plasmas.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The ESS spoke cavity cryomodules

The European Spallation Source (ESS) is a multi-disciplinary research centre under design and construction in Lund, Sweden. This new facility is funded by a collaboration of 17 European countries and is expected to be up to 30 times brighter than today’s leading facilities and neutron sources. The ESS will enable new opportunities for researchers in the fields of life sciences, energy, environmental technology, cultural heritage and fundamental physics. A 5 MW long pulse proton accelerator is used to reach this goal. The pulsed length is 2.86 ms, the repetition frequency is 14 Hz (4 % duty cycle), and the beam current is 62.5 mA. It is composed of one string of spoke cavity cryomodule and two strings of elliptical cavity cryomodules. This paper introduces the thermo-mechanical design and expected operation of the ESS spoke cavity cryomodules. These cryomodules contain two double spoke bulk Niobium cavities operating at 2 K and at a frequency of 352.21 MHz. The superconducting section of the Spoke Linac accelerates the beam from 90 MeV to 220 MeV. A Spoke Cavity Cryomodule Technology Demonstrator will be built and tested in order to validate the ESS series production.

43 PARTICLE ACCELERATORS↗

SAMS Acceleration Measurement on Mir From March to September 1996

During NASA Increment 2 (March to September 1996), over 15 gigabytes of acceleration data were collected by the Space Acceleration Measurement System (SAMS) onboard the Russian Space Station, Mir. The data were recorded on 55 optical disks and were returned to Earth on STS-79. During this time, SAMS data were collected in the Kristall and Kvant modules, and in the Priroda module to support the following experiments: the Queen's University Experiments in Liquid Diffusion (QUELD), the Technological Evaluation of the MIM (TEM), the Forced Flow Flame Spreading Test (FFFT), and Candle Flames in Microgravity (CFM). This report points out some of the salient features of the microgravity environment to which these experiments were exposed. Also documented are mission events of interest such as the docked phase of STS-76 operations, an extravehicular activity (EVA) to install and deploy solar panels on the Kvant module, a Progress engine burn to raise Mir's altitude, and an on-orbit SAMS calibration procedure. Also included are a description of the Mir module orientations, and the panel notations within the modules. This report presents an overview of the SAMS acceleration measurements recorded by 10 Hz and 100 Hz sensor heads. Variations in the acceleration environment caused by unique activities such as crew exercise and life-support fans are presented. The analyses included herein complement those presented in previous mission summary reports published by the Principal Investigator Microgravity Services (PIMS) group.

Moskowitz, Milton E.↗

SU-E-T-631: Commissioning and Comprehensive Evaluation of the ArcCHECK Cylindrical Diode Array for VMAT QA

Purpose: Commissioning and comprehensive evaluation of ArcCHECK phantom for dosimetry of VMAT QA, using 6MV photon beam with and without the flattening filter. Methods: ArcCHECK was evaluated for response dependency on linac dose rate, instantaneous dose rate, radiation field size, beam angle and couch insertion. Scatter dose characterization, consistency and symmetry of response, dosimetric accuracy of fixed aperture arcs and clinical VMAT plans were investigated. Measurements were done using TrueBeam™ STx accelerator (Console version 1.6) with a 6 MV beam with and without flattening filter. Reference dose-grids were calculated using Eclipse TPS Analytical Anisotropic Algorithm (AAA version 10.0.39). Planned doses were calculated using symmetric 2mm 3D dose grids with 4 degree angular resolution defaulted to each control point. Gamma evaluations were performed in absolute dose mode, with default normalization to maximum dose in the curved plane and a low dose threshold of 10% to restrict the analysis to clinically relevant areas. Global and local gamma indices at 3mm/3% and 2mm/2% level were computed using SNC software (version 6.0). Results: Results of gamma analysis demonstrated an overall agreement between ArcCHECK measured and TPS calculated reference doses. Field size dependency was within 0.5% of the reference. Dose-rate based dependency was well within 1% of the TPS reference and the angular dependency was ±3% of the reference, as tested for BEV angles. At the level of 3%/3mm, narrow and wide open arcs as well as clinical VMAT cases demonstrated high level of dosimetry accuracy in global gamma passing rates for both 6X and 6F beams. At the level of 2%/2mm two VMAT cases involving the narrow heavily modulated arcs demonstrated lower passing rates. Conclusion: ArcCHECK phantom with latest software and hardware upgrades is suitable for VMAT QA. For higher sensitivity of 2%/2mm gamma analysis, we intend to use it as one of the VMAT QA evaluation metrics.

07 ISOTOPE AND RADIATION SOURCES↗

The ESS elliptical cavity cryomodules

The European Spallation Source (ESS) is a multi-disciplinary research centre under design and construction in Lund, Sweden. This new facility is funded by a collaboration of 17 European countries and is expected to be up to 30 times brighter than today’s leading facilities and neutron sources. The ESS will enable new opportunities for researchers in the fields of life sciences, energy, environmental technology, cultural heritage and fundamental physics. A 5 MW long pulse proton accelerator is used to reach this goal. The pulsed length is 2.86 ms, the repetition frequency is 14 Hz (4 % duty cycle), and the beam current is 62.5 mA. The superconducting section of the Linac accelerates the beam from 80 MeV to 2.0 GeV. It is composed of one string of spoke cavity cryomodule and two strings of elliptical cavity cryomodules. These cryomodules contain four elliptical Niobium cavities operating at 2 K and at a frequency of 704.42 MHz. This paper introduces the thermo-mechanical design, the prototyping and the expected operation of the ESS elliptical cavity cryomodules. An Elliptical Cavity Cryomodule Technology Demonstrator (ECCTD) will be built and tested in order to validate the ESS series production.

43 PARTICLE ACCELERATORS↗

A New Analysis Tool Assessment for Rotordynamic Modeling of Gas Foil Bearings

Gas foil bearings offer several advantages over traditional bearing types that make them attractive for use in high-speed turbomachinery. They can operate at very high temperatures, require no lubrication supply (oil pumps, seals, etc.), exhibit very long life with no maintenance, and once operating airborne, have very low power loss. The use of gas foil bearings in high-speed turbomachinery has been accelerating in recent years, although the pace has been slow. One of the contributing factors to the slow growth has been a lack of analysis tools, benchmarked to measurements, to predict gas foil bearing behavior in rotating machinery. To address this shortcoming, NASA Glenn Research Center (GRC) has supported the development of analytical tools to predict gas foil bearing performance. One of the codes has the capability to predict rotordynamic coefficients, power loss, film thickness, structural deformation, and more. The current paper presents an assessment of the predictive capability of the code, named XLGFBTH (Texas A&M University). A test rig at GRC is used as a simulated case study to compare rotordynamic analysis using output from the code to actual rotor response as measured in the test rig. The test rig rotor is supported on two gas foil journal bearings manufactured at GRC, with all pertinent geometry disclosed. The resulting comparison shows that the rotordynamic coefficients calculated using XLGFBTH represent the dynamics of the system reasonably well, especially as they pertain to predicting critical speeds.

Howard, Samuel A.↗

Observation Platform for Dynamic Biomedical and Biotechnology Experiments Using the International Space Station (ISS) Light Microscopy Module (LMM)

Techshot, Inc., has developed an observation platform for the LMM on the ISS that will enable biomedical and biotechnology experiments. The LMM Dynamic Stage consists of an electronics module and the first two of a planned suite of experiment modules. Specimens and reagent solutions can be injected into a small, hollow microscope slide-the heart of the innovation-via a combination of small reservoirs, pumps, and valves. A life science experiment module allows investigators to load up to two different fluids for on-orbit, real-time image cytometry. Fluids can be changed to initiate a process, fix biological samples, or retrieve suspended cells. A colloid science experiment module conducts microparticle and nanoparticle tests for investigation of colloid self-assembly phenomena. This module includes a hollow glass slide and heating elements for the creation of a thermal gradient from one end of the slide to the other. The electronics module supports both experiment modules and contains a unique illuminator/condenser for bright and dark field and phase contrast illumination, power supplies for two piezoelectric pumps, and controller boards for pumps and valves. This observation platform safely contains internal fluids and will greatly accelerate the research and development (R&D) cycle of numerous experiments, products, and services aboard the ISS.

Kurk, Michael A. (Andy)↗

Observation Platform for Dynamic Biomedical and Biotechnology Experiments Using the International Space Station (ISS) Light Microscopy Module (LMM)

Techshot, Inc., has developed an observation platform for the LMM on the ISS that will enable biomedical and biotechnology experiments. The LMM Dynamic Stage consists of an electronics module and the first two of a planned suite of experiment modules. Specimens and reagent solutions can be injected into a small, hollow microscope slide-the heart of the innovation-via a combination of small reservoirs, pumps, and valves. A life science experiment module allows investigators to load up to two different fluids for on-orbit, real-time image cytometry. Fluids can be changed to initiate a process, fix biological samples, or retrieve suspended cells. A colloid science experiment module conducts microparticle and nanoparticle tests for investigation of colloid self-assembly phenomena. This module includes a hollow glass slide and heating elements for the creation of a thermal gradient from one end of the slide to the other. The electronics module supports both experiment modules and contains a unique illuminator/condenser for bright and dark field and phase contrast illumination, power supplies for two piezoelectric pumps, and controller boards for pumps and valves. This observation platform safely contains internal fluids and will greatly accelerate the research and development (R&D) cycle of numerous experiments, products, and services aboard the ISS.

Kurk, Michael A. (Andy)↗

SU-E-T-226: Correction of a Standard Model-Based Dose Calculator Using Measurement Data

Purpose: To propose a hybrid method that combines advantages of the model-based and measurement-based method for independent dose calculation. Modeled-based dose calculation, such as collapsed-cone-convolution/superposition (CCCS) or the Monte-Carlo method, models dose deposition in the patient body accurately; however, due to lack of detail knowledge about the linear accelerator (LINAC) head, commissioning for an arbitrary machine is tedious and challenging in case of hardware changes. On the contrary, the measurement-based method characterizes the beam property accurately but lacks the capability of dose disposition modeling in heterogeneous media. Methods: We used a standard CCCS calculator, which is commissioned by published data, as the standard model calculator. For a given machine, water phantom measurements were acquired. A set of dose distributions were also calculated using the CCCS for the same setup. The difference between the measurements and the CCCS results were tabulated and used as the commissioning data for a measurement based calculator. Here we used a direct-ray-tracing calculator (ΔDRT). The proposed independent dose calculation consists of the following steps: 1. calculate D-model using CCCS. 2. calculate D-ΔDRT using ΔDRT. 3. combine Results: D=D-model+D-ΔDRT. Results: The hybrid dose calculation was tested on digital phantoms and patient CT data for standard fields and IMRT plan. The results were compared to dose calculated by the treatment planning system (TPS). The agreement of the hybrid and the TPS was within 3%, 3 mm for over 98% of the volume for phantom studies and lung patients. Conclusion: The proposed hybrid method uses the same commissioning data as those for the measurement-based method and can be easily extended to any non-standard LINAC. The results met the accuracy, independence, and simple commissioning criteria for an independent dose calculator.

60 APPLIED LIFE SCIENCES↗

Poster - 53: Improving inter-linac DMLC IMRT dose precision by fine tuning of MLC leaf calibration

Purpose: To develop a method to improve the inter-linac precision of DMLC IMRT dosimetry. Methods: The distance between opposing MLC leaf banks (“gap size”) can be finely tuned on Varian linacs. The dosimetric effect due to small deviations from the nominal gap size (“gap error”) was studied by introducing known errors for several DMLC sliding gap sizes, and for clinical plans based on the TG119 test cases. The plans were delivered on a single Varian linac and the relationship between gap error and the corresponding change in dose was measured. The plans were also delivered on eight Varian 2100 series linacs (at two institutions) in order to quantify the inter-linac variation in dose before and after fine tuning the MLC calibration. Results: The measured dose differences for each field agreed well with the predictions of LoSasso et al. Using the default MLC calibration, the variation in the physical MLC gap size was determined to be less than 0.4 mm between all linacs studied. The dose difference between the linacs with the largest and smallest physical gap was up to 5.4% (spinal cord region of the head and neck TG119 test case). This difference was reduced to 2.5% after fine tuning the MLC gap calibration. Conclusions: The inter-linac dose precision for DMLC IMRT on Varian linacs can be improved using a simple modification of the MLC calibration procedure that involves fine adjustment of the nominal gap size.

60 APPLIED LIFE SCIENCES↗