Search NASA⌕ Search

SEARCH · Search NASA

Results for “Life Testing”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 865 records · Page 48
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

FY 2016 Status Report: CIRFT Testing Data Analyses and Updated Curvature Measurements

This report provides a detailed description of FY15 test result corrections/analysis based on the FY16 Cyclic Integrated Reversible-Bending Fatigue Tester (CIRFT) test program methodology update used to evaluate the vibration integrity of spent nuclear fuel (SNF) under normal transportation conditions. The CIRFT consists of a U-frame testing setup and a real-time curvature measurement method. The three-component U-frame setup of the CIRFT has two rigid arms and linkages to a universal testing machine. The curvature of rod bending is obtained through a three-point deflection measurement method. Three linear variable differential transformers (LVDTs) are used and clamped to the side connecting plates of the U-frame to capture the deformation of the rod. The contact-based measurement, or three-LVDT-based curvature measurement system, on SNF rods has been proven to be quite reliable in CIRFT testing. However, how the LVDT head contacts the SNF rod may have a significant effect on the curvature measurement, depending on the magnitude and direction of rod curvature. It has been demonstrated that the contact/curvature issues can be corrected by using a correction on the sensor spacing. The sensor spacing defines the separation of the three LVDT probes and is a critical quantity in calculating the rod curvature once the deflections are obtained. The sensor spacing correction can be determined by using chisel-type probes. The method has been critically examined this year and has been shown to be difficult to implement in a hot cell environment, and thus cannot be implemented effectively. A correction based on the proposed equivalent gauge-length has the required flexibility and accuracy and can be appropriately used as a correction factor. The correction method based on the equivalent gauge length has been successfully demonstrated in CIRFT data analysis for the dynamic tests conducted on Limerick (LMK) (17 tests), North Anna (NA) (6 tests), and Catawba mixed oxide (MOX) (10 tests) SNF samples. These CIRFT tests were completed in FY14 and FY15. Specifically, the data sets obtained from measurement and monitoring were processed and analyzed. The fatigue life of rods has been characterized in terms of moment, curvature, and equivalent stress and strain..

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2018

Stromal interaction molecule 1 is required for neonatal testicular development in mice

Highlights: • STIM1 is found in Sertoli cells and associated with neonatal testicular development. • STIM1 is required for Sertoli cell orientation and germ cell survival. • Stim1 knockdown in neonatal testis altered the testicular phenotype and induced ROS. • ROS inhibition partially rescued the Stim1 knockdown phenotype in neonatal testes. • STIM1 can maintain neonatal testicular development by inhibiting ROS activation. Stromal interaction molecule 1 (STIM1) is a transmembrane endoplasmic reticulum protein, and it serves as a Ca{sup 2+} sensor and activator of store-operated Ca{sup 2+} entry (SOCE). We have previously identified STIM1 in the proteome profile of mice neonatal testes, revealing STIM1 to be associated with neonatal testicular development. Here, to further explore the location and function of STIM1 in mice testes, we studied the effect of Stim1 gene knockdown on neonatal testicular development by testicular culture. Our results revealed that STIM1 was primarily located in Sertoli cells. Knockdown of Stim1 gene using morpholino in neonatal testis caused the mislocation of Sertoli cells and loss of germ cells, which were associated with the aberrant reactive oxygen species (ROS) activation, while inhibition of ROS could partly rescue the phenotypes caused by Stim1 gene knockdown. In conclusion, our study suggests that STIM1 can maintain neonatal testicular development by inhibiting ROS activation.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

Evaluation of Radiolysis Data for Hydrogen Gas Generation During Gamma Irradiation of Pre-Corroded and Pristine Aluminum Samples - An Aluminum SNF Dry Storage Study Interim Report

Information and data from radiolysis testing to measure hydrogen (H₂) generated from hydrated oxides on aluminum exposed to ⁶⁰Co radiation were reviewed to evaluate hydrogen generation with radiation dose. Hydrogen generation rate is a primary input to the coupled thermal-chemical system model of the performance of aluminum-clad spent nuclear fuel in a dry storage canister (ASNF-in-canister) over its storage life. Hydrogen generation data and hydrogen generation rate (hydrogen generated per absorbed radiation dose, $\Delta$(H₂)/$\Delta$(dose)) were reported in two reports for radiolysis testing [1, 2]. The testing involved first-time data¹ for radiolytic yield of hydrogen from hydrated-oxides-on-aluminum substrates, and from pristine (non-corroded) aluminum substrates. The laboratory-grown hydrated-oxides-on-aluminum substrates contained a ~ 5 μm film consisting of the trihydroxide bayerite (Al(OH)₃) with amounts of the oxyhydroxide boehmite (AlOOH). These specimens were assumed to also contain physisorbed water (unquantified). The pristine substrates were flat coupons of aluminum that were ground to a 600-grit finish but were not immersed in water to grow a hydrated oxide. The pristine substrates were tested as companion specimens to provide information on hydrogen generation from material without chemisorbed water and were assumed to contain physisorbed water (unquantified).

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2019

A Practical Approach of Mining Operational Risks in Cigeo - A field-test - 19349

Andra is currently completing the detailed engineering phase of the stepwise design development of Cigeo (the French HLW and IL-LLW Deep Geological Repository, aka DGR). Various technical issues are at stake, including the risk management requirements linked to the safety of 'Mining Operations' (i.e. occupational safety issues related to underground excavation/dismantling works at some 500 m of depth), at different stages of the DGR life cycle (i.e. from its construction start-up to its final closure and future monitoring/or conversely a decision of waste retrieval). These occupational safety requirements have a significant impact on Cigeo's design, its progressive construction and later closure. On a shorter term, one must demonstrate that the design bases are technically sound and that the solutions selected (to build, operate, close the DGR infrastructures or conversely retrieve the waste) are both feasible and safe. In that sense (and following an identification of operational risks during construction), Andra focused on two sensitive cases: - The construction of large diameter drift crossings, in particular those related to the connection between a transfer drift (main) and a IL-LLW disposal vault (i.e. during construction operations), - The partial dismantling of a drift concrete lining (made of concrete segment rings, erected and placed by a TBM) at time of construction of a horizontal seal (i.e. during closure operations). The discussion starts with a description of the geotechnical conditions prevailing at the (French) Bure site, in the Callovo-Oxfordian (COx) claystone formation. Then the paper presents the Cigeo underground architecture (at large) and the specific structural choices made (at the end of the detailed engineering phase) for drifts, disposal vaults and seals. The discussion on construction - deconstruction challenges for each of the critical issues cited above provides an opportunity to explain the operational sequences (and how the methodology selected enables to reduce the risks). The following part of the paper focuses the technological demonstration (an in-situ test to be planned in detail) of a partial dismantling of the concrete segments rings forming the support lining of two tunnels previously built in the Meuse/Haute-Marne URL (Underground Research Laboratory) infrastructures, combined with the construction of a specific drift crossing. In this dismantling and construction test, the technical demonstration objective is three-fold: - The capacity to lay down compressible arch segments and support (by bolts and mesh) the rock after the lining removal, - The capacity to excavate and line the drift crossing, - The structural / geomechanical behavior (evolution with time) of the rock and lining compared with that of 'neighboring' zones. This paper provides a timeline of the tests. Should the results obtained deliver some positive perspectives of technical feasibility (and convincing operational safety) Andra will incorporate this dismantling/construction solution in the 'design freeze' of the DGR underground infrastructures. The positive outcomes of this technical test campaign will also provide 'elements of proof' for the instruction of the Cigeo licensing (a process likely to take place between 2020 and 2024) by the French Nuclear Safety Authority (ASN). (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2016

FY 2017 Stockpile Stewardship and Management Plan - Biennial Plan Summary

This year’s summary report updates the Fiscal Year 2016 Stockpile Stewardship and Management Plan (FY 2016 SSMP), the 25-year strategic program of record that captures the plans developed across numerous NNSA programs and organizations to maintain and modernize the scientific tools, capabilities, and infrastructure necessary to ensure the success of NNSA’s nuclear weapons mission. The SSMP is a companion to the Prevent, Counter, and Respond: A Strategic Plan to Reduce Global Nuclear Threats (FY 2017-2021) report, the planning document for NNSA’s nuclear threat reduction mission. New versions of both reports are published each year in response to new requirements and challenges. Much was accomplished in FY 2015 as part of the program of record described in this year’s SSMP. The science-based Stockpile Stewardship Program allowed the Secretaries of Energy and Defense to certify for the twentieth time that the stockpile remains safe, secure, and effective without the need for underground nuclear explosive testing. The talented scientists, engineers, and technicians at the three national security laboratories, the four nuclear weapons production plants, and the national security site are primarily responsible for this continued success. Research, development, test, and evaluation programs have advanced NNSA’s understanding of weapons physics, component aging, and material properties through first-of-a-kind shock physics experiments, along with numerous other critical experiments conducted throughout the nuclear security enterprise. The multiple life extension programs (LEPs) that are under way made progress toward their first production unit dates. The W76-1 LEP is past the halfway point in total production, and the B61-12 completed three development flight tests. Critical to this success is the budget. The Administration’s budget request for NNSA’s Weapons Activities has increased for all but one of the past seven years, resulting in a total increase of approximately 45 percent since 2010. If adopted by Congress, the FY 2017 budget request will increase funding by $396 million (about 4.5 percent) from the enacted FY 2016 level. A significant portion of the increase would fund the research for multiple life extension programs, support the programs in Directed Stockpile Work, and modernize the physical infrastructure of the nuclear security enterprise.

Source record↗
DOE OSTI2014

Chemo-physical properties of renal capsules under ultraviolet-c exposure

The renal capsule tissue of lamb was irradiated with ultraviolet-C light and the treated samples were analyzed by uniaxial tensile test, dynamic mechanical analysis, attenuated total reflectance Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and contact angle measurements. It was shown that the skin cross-linking is dominant in low doses in accordance with the contact angle assessment. Conversely, the strong bulk degradation takes place at high doses. Similarly, the bulk cross-linking affects the mechanical tests as to enhance the stiffness at low doses, whereas strong degradation occurs at high doses that mainly arises from the strong bulk chain scission.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

SU-F-T-480: Evaluation of the Role of Varian Machine Performance Check (MPC) in Our Daily QA Routine

Purpose: (A) To assess the role of Varian MPC in our daily QA routine, and (B) evaluate the accuracy and precision of MPC. Methods: The MPC was performed weekly, for five months, on a Varian TrueBeam for five photon (6x, 10x, 15x, 6xFFF, and 10xFFF) and electron (6e, 9e, 12e, 16e, and 20e) energies. Output results were compared to those determined with an ionization chamber (TN30001, PTW-Freiburg) in plastic and a daily check device (DQA3, Sun Nuclear). Consistency of the Mechanical measurements over five months was analyzed and compared to monthly IsoCal results. Results: The MPC randomly showed large deviations (3–7%) that disappeared upon reacquisition. The MPC output closely matched monthly ion chamber and DQA3 measurements. The maximum and mean absolute difference between monthly and MPC was 1.18% and 0.28±0.21% for all energies. The maximum and mean absolute difference between DQA3 and MPC was 3.26% and 0.85±0.61%. The results suggest the MPC is comparable to the DQA3 for measuring output. The DQA3 provides wedge output, flatness, symmetry, and energy constancy checks, which are missing from the current implementation of the MPC. However, the MPC provides additional mechanical tests, such as size of the radiation isocenter (0.33±0.02 mm) and its coincidence with MV and kV isocenters (0.17±0.05 and 0.21±0.03 mm). It also provides positional accuracy of individual jaws (maximum σ, 0.33mm), all the MLC leaves (0.08mm), gantry (0.05°) and collimator (0.13°) rotation angles, and couch positioning (0.11mm) accuracy. MPC mechanical tests could replace our current daily on-board imaging QA routine and provide some additional QA not currently performed. Conclusion: MPC has the potential to be a valuable tool that facilitates reliable daily QA including many mechanical tests that are not currently performed. This system can add to our daily QA, but further development would be needed to fully replace our current Daily QA device.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2017

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database

The contribution of animal testing in drug development has been widely debated and challenged. An industry-wide nonclinical to clinical translational database was created to determine how safety assessments in animal models translate to First-In-Human clinical risk. The blinded database was composed of 182 molecules and contained animal toxicology data coupled with clinical observations from phase I human studies. Animal and clinical data were categorized by organ system and correlations determined. The 2 × 2 contingency table (true positive, false positive, true negative, false negative) was used for statistical analysis. Sensitivity was 48% with a 43% positive predictive value (PPV). The nonhuman primate had the strongest performance in predicting adverse effects, especially for gastrointestinal and nervous system categories. When the same target organ was identified in both the rodent and nonrodent, the PPV increased. Specificity was 84% with an 86% negative predictive value (NPV). The beagle dog had the strongest performance in predicting an absence of clinical adverse effects. If no target organ toxicity was observed in either test species, the NPV increased. While nonclinical studies can demonstrate great value in the PPV for certain species and organ categories, the NPV was the stronger predictive performance measure across test species and target organs indicating that an absence of toxicity in animal studies strongly predicts a similar outcome in the clinic. These results support the current regulatory paradigm of animal testing in supporting safe entry to clinical trials and provide context for emerging alternate models. - Highlights: • Translational database created to determine animal to human safety concordance. • 182 molecules with animal and clinical data; concordance parameters determined • Positive predictive value of 43%; Negative predictive value of 86% • Absence of toxicity in animal study strongly predicts similar outcome in the clinic. • Database supports animal testing to ensure human safety in the clinic.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Advanced High Torque Density Magnetically Geared Generator

The objective of this research project was to investigate the fundamental torque density limitations of multistage flux focusing magnetic gears and magnetically geared direct-drive generators for wind turbines. Magnetic gears create non-contact speed amplification by modulating the air-gap magnetic field harmonics created by magnetic rotors. By integrating a stator into the magnetic gear structure a very high torque density direct-drive generator can be created. Magnetic geared systems offer unique capabilities that are currently not available using existing mechanically geared systems, such as overload protection. Magnetic gears also offer the potential for higher reliability, higher efficiency and quieter operation than is currently achievable using a mechanically geared generator. By increasing reliability and design life magnetic gears could decrease the overall life-cycle costs when compared with equivalent mechanical or direct-drive drivetrains. This research project investigated and experimentally testing two sub-scale magnetic gearboxes (0.12 m diameter) and two large diameter magnetic gearboxes (0.56m and 0.63m diameter). The goal of the project was to demonstrate a torque density >300Nm/L for a multistage magnetic gearbox with integrated stator. A nested multistage magnetic gear structure was first proposed and studied. However, it was shown that the nested design greatly increased mechanical complexity and therefore a two-stage series typology was utilized. A multi-stage magnetic gear with a 59:1 gear ratio was successfully experimentally tested. A peak torque of 4.25 kN·m was measured and this resulted in an overall active region torque density of 141 N·m/L (when including support rings). The torque density was significantly reduced from what was computed using 2-D electromagnetic analysis. This reduction was due to the 3-D edge effects, increased power losses and the inclusion of additional mechanical support rings as well as other mechanical assembly design changes. At large diameters contiguous lamination parts could not be fabricated and so a segmented laminated rotor design had to be used. This reduced the mechanical strength of the design when compared to small diameter magnetic gears and resulted in the need for the addition of mechanical support rings to prevent deflection. The final experimentally tested design also had a high torque ripple and the power loss within the magnetic gear did not change significantly with load. This therefore resulted in the efficiency being high only at peak loads. Despite not experimentally achieving the 2-D calculated high torque density the analysis has shown that the problems encountered with the scaling can be overcome with careful design changes. For example, understanding the unique mechanical deflection requirements during the electromagnetic design of the large diameter magnetic gears is key to achieving both a high torque density based on the electromagnetic analysis and a high torque density based on the mechanical support needs. Furthermore, ensuring that end plates are made of non-conductive material and minimizing other conductive support elements within the magnetic structure is a key requirement for reducing eddy current losses. In summary, if the mechanical design can be made more robust and eddy current loss mitigation strategies are used in the mechanical design phase then the magnetic gear is capable of being scaled up whilst operating at a very high torque density. This will then enable it to be potentially performance and cost competitive with alternative direct-drive and mechanically geared wind turbine drivetrains.

17 WIND ENERGY↗
DOE OSTI2015

Mechanism of the Delithiation/Lithiation Process in LiFe 0.4 Mn 0.6 PO 4 : in Situ and ex Situ Investigations on Long-Range and Local Structures

LiFe 0.4 Mn 0.6 PO 4 olivine was prepared by a sol–gel route, using citric acid as a chelating agent and NH 4 H 2 PO 4 as a phosphorus source. Sucrose was used as the source for the carbon-coating of the particles. The correlation between the physicochemical and the electrochemical properties of this positive electrode material was explored. The electrochemical tests showed an initial discharge capacity of 121 mAh/g at a C/20 rate with a good reversibility of the lithiation/delithiation reactions. In situ XRD on LiFe 0.4 Mn 0.6 PO 4 reveals the occurrence of new phases upon cycling, which disappeared again at the end of discharge. The single phase observed after one complete cycle is identical to the pristine one. In situ XAS spectroscopy in combination with 57 Fe Mössbauer and 7 Li NMR spectroscopy were used to investigate the changes in the local structure and the oxidation states of the transition metals and thus to complete the overall characterization of the lithiation/delithiation mechanism. All findings reveal a high reversibility of the reactions in this electrode material.

36 MATERIALS SCIENCE↗
DOE OSTI2019

Microstructure and Three-Point Bending Fatigue Behavior of Al-Cu-Mg-Ag Alloys with Various Mg Contents

This paper presents an investigation on the influence of Mg content on the microstructures, tensile properties and three-point bending fatigue behavior of Al-Cu-Mg-Ag alloys. The results indicate that the alloy containing 0.70 wt.% Mg possesses lower tensile properties and higher fatigue performance compared to the one with 1.15 wt.% Mg. Increasing Mg content in Al-Cu-Mg-Ag alloys can enhance the nucleation and precipitation of Ω phase, as well as increase the volume fraction and number density of constituent particles. The investigation of the fatigue crack initiation and growth behavior of Al-Cu-Mg-Ag alloy using interrupted fatigue tests suggests that micro-cracks mainly nucleate on Al{sub 2}Cu constituent particles and the fatigue life is mainly associated with the density of constituent particles.

36 MATERIALS SCIENCE↗
DOE OSTI2026

Drive Cycles, Battery Pack Scaling, and Usage Considerations for Long-Haul and Regional-Haul Electric Trucks

Electrifying Class-8 heavy-duty trucks presents a promising opportunity to enhance energy efficiency and reduce freight transport costs. Battery electric trucks (BETs), once considered niche, are gaining traction due to advancements in battery technology and cost reductions. However, accurately predicting battery lifespan under realistic usage conditions remains a key challenge. Understanding battery failure mechanisms and their links to design, operation, and management is essential for developers and fleet operators. This study introduces a method to develop simplified, lab-testable dynamic stress test (DST) cycles for regional and long-haul Class-8 BETs, derived from real-world diesel truck usage. These DSTs enable benchmarking of battery technologies, identification of aging stressors, and optimization of battery design, life, and cost. The approach supports evaluation of key metrics such as levelized cost of driving and total cost of ownership, aiding fair comparisons and adoption decisions. We also propose feasible battery pack sizes that meet current driving demands with strategic charging, and a method to scale pack-level DSTs to cell-level cycles for lab-based testing. These tools facilitate tradeoff analysis across battery chemistries, pack sizing, and charging strategies, while offering means to get insights into battery aging under realistic conditions-ultimately supporting informed BET deployment decisions.

25 ENERGY STORAGE↗
DOE OSTI2014

Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: Effects of CREB pathway inhibition

According to the advocated paradigm shift in toxicology, acquisition of knowledge on the mechanisms underlying the toxicity of chemicals, such as perturbations of biological pathways, is of primary interest. Pluripotent stem cells (PSCs), such as human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), offer a unique opportunity to derive physiologically relevant human cell types to measure molecular and cellular effects of such pathway modulations. Here we compared the neuronal differentiation propensity of hESCs and hiPSCs with the aim to develop novel hiPSC-based tools for measuring pathway perturbation in relation to molecular and cellular effects in vitro. Among other fundamental pathways, also, the cAMP responsive element binding protein (CREB) pathway was activated in our neuronal models and gave us the opportunity to study time-dependent effects elicited by chemical perturbations of the CREB pathway in relation to cellular effects. We show that the inhibition of the CREB pathway, using 2-naphthol-AS-E-phosphate (KG-501), induced an inhibition of neurite outgrowth and synaptogenesis, as well as a decrease of MAP2{sup +} neuronal cells. These data indicate that a CREB pathway inhibition can be related to molecular and cellular effects that may be relevant for neurotoxicity testing, and, thus, qualify the use of our hiPSC-derived neuronal model for studying chemical-induced neurotoxicity resulting from pathway perturbations. - Highlights: • HESCs derived neuronal cells serve as benchmark for iPSC based neuronal toxicity test development. • Comparisons between hESCs and hiPSCs demonstrated variability of the epigenetic state • CREB pathway modulation have been explored in relation to the neurotoxicant exposure KG-501 • hiPSC might be promising tools to translate theoretical AoPs into toxicological in vitro tests.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2014

SU-C-9A-04: Alternative Analytic Solution to the Paralyzable Detector Model to Calculate Deadtime and Deadtime Loss

Purpose: Some common methods to solve for deadtime are (1) dual-source method, which assumes two equal activities; (2) model fitting, which requires multiple acquisitions as source decays; and (3) lossless model, which assumes no deadtime loss at low count rates. We propose a new analytic alternative solution to calculate deadtime for paralyzable gamma camera. Methods: Deadtime T can be calculated analytically from two distinct observed count rates M1 and M2 when the ratio of the true count rates alpha=N2/N1 is known. Alpha can be measured as a ratio of two measured activities using dose calibrators or via radioactive decay. Knowledge of alpha creates a system with 2 equations and 2 unknowns, i.e., T and N1. To verify the validity of the proposed method, projections of a non-uniform phantom (4GBq 99mTc) were acquired in using Siemens SymbiaS multiple times over 48 hours. Each projection has >100kcts. The deadtime for each projection was calculated by fitting the data to a paralyzable model and also by using the proposed 2-acquisition method. The two estimates of deadtime were compared using the Bland-Altmann method. In addition, the dependency of uncertainty in T on uncertainty in alpha was investigated for several imaging conditions. Results: The results strongly suggest that the 2-acquisition method is equivalent to the fitting method. The Bland-Altman analysis yielded mean difference in deadtime estimate of ∼0.076us (95%CI: -0.049us, 0.103us) between the 2-acquisition and model fitting methods. The 95% limits of agreement were calculated to be -0.104 to 0.256us. The uncertainty in deadtime calculated using the proposed method is highly dependent on the uncertainty in the ratio alpha. Conclusion: The 2-acquisition method was found to be equivalent to the parameter fitting method. The proposed method offers a simpler and more practical way to analytically solve for a paralyzable detector deadtime, especially during physics testing.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2015

Technical Report: TG-142 compliant and comprehensive quality assurance tests for respiratory gating

Purpose: To develop and establish a comprehensive gating commissioning and quality assurance procedure in compliance with TG-142. Methods: Eight Varian TrueBeam Linacs were used for this study. Gating commissioning included an end-to-end test and baseline establishment. The end-to-end test was performed using a CIRS dynamic thoracic phantom with a moving cylinder inside the lung, which was used for carrying both optically simulated luminescence detectors (OSLDs) and Gafchromic EBT2 films while the target is moving, for a point dose check and 2D profile check. In addition, baselines were established for beam-on temporal delay and calibration of the surrogate, for both megavoltage (MV) and kilovoltage (kV) beams. A motion simulation device (MotionSim) was used to provide periodic motion on a platform, in synchronizing with a surrogate motion. The overall accuracy and uncertainties were analyzed and compared. Results: The OSLD readings were within 5% compared to the planned dose (within measurement uncertainty) for both phase and amplitude gated deliveries. Film results showed less than 3% agreement to the predicted dose with a standard sinusoid motion. The gate-on temporal accuracy was averaged at 139 ± 10 ms for MV beams and 92 ± 11 ms for kV beams. The temporal delay of the surrogate motion depends on the motion speed and was averaged at 54.6 ± 3.1 ms for slow, 24.9 ± 2.9 ms for intermediate, and 23.0 ± 20.1 ms for fast speed. Conclusions: A comprehensive gating commissioning procedure was introduced for verifying the output accuracy and establishing the temporal accuracy baselines with respiratory gating. The baselines are needed for routine quality assurance tests, as suggested by TG-142.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

SU-F-T-475: An Evaluation of the Overlap Between the Acceptance Testing and Commissioning Processes for Conventional Medical Linear Accelerators

Purpose: This work’s objective is to determine the overlap of processes, in terms of sub-processes and time, between acceptance testing and commissioning of a conventional medical linear accelerator and to evaluate the time saved by consolidating the two processes. Method: A process map for acceptance testing for medical linear accelerators was created from vendor documentation (Varian and Elekta). Using AAPM TG-106 and inhouse commissioning procedures, a process map was created for commissioning of said accelerators. The time to complete each sub-process in each process map was evaluated. Redundancies in the processes were found and the time spent on each were calculated. Results: Mechanical testing significantly overlaps between the two processes - redundant work here amounts to 9.5 hours. Many beam non-scanning dosimetry tests overlap resulting in another 6 hours of overlap. Beam scanning overlaps somewhat - acceptance tests include evaluating PDDs and multiple profiles but for only one field size while commissioning beam scanning includes multiple field sizes and depths of profiles. This overlap results in another 6 hours of rework. Absolute dosimetry, field outputs, and end to end tests are not done at all in acceptance testing. Finally, all imaging tests done in acceptance are repeated in commissioning, resulting in about 8 hours of rework. The total time overlap between the two processes is about 30 hours. Conclusion: The process mapping done in this study shows that there are no tests done in acceptance testing that are not also recommended to do for commissioning. This results in about 30 hours of redundant work when preparing a conventional linear accelerator for clinical use. Considering these findings in the context of the 5000 linacs in the United states, consolidating acceptance testing and commissioning would have allowed for the treatment of an additional 25000 patients using no additional resources.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2022

LANL Contributions to pyiron: An integrated development environment for computational materials science

To support and accelerate the development of simulation protocols in atomistic modelling, we introduce an integrated development environment (IDE) for computational materials science called pyiron (http://pyiron.org). The pyiron IDE combines a web based source code editor, a job management system for build automation, and a hierarchical data management solution. The core components of the pyiron IDE are pyiron objects based on an abstract class, which links application structures such as atomistic structures, projects, jobs, simulation protocols and computing resources with persistent storage and an interactive user environment. The simulation protocols within the pyiron IDE are constructed using the Python programming language. To highlight key concepts of this tool as well as to demonstrate its ability to simplify the implementation and testing of simulation protocols we discuss two applications. In these examples we show how pyiron supports the whole life cycle of a typical simulation, seamlessly combines ab initio with empirical potential calculations, and how complex feedback loops can be implemented. While originally developed with focus on ab initio thermodynamics simulations, the concepts and implementation of pyiron are general thus allowing to employ it for a wide range of simulation topics.

Janssen, Jan↗