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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 91 records · Page 5

Increased susceptibility to Pseudomonas aeruginosa infection under hindlimb-unloading conditions

It has been reported that spaceflight conditions alter the immune system and resistance to infection [Belay T, Aviles H, Vance M, Fountain K, and Sonnenfeld G. J Allergy Clin Immunol 170: 262-268, 2002; Hankins WR and Ziegelschmid JF. In: Biomedical Results of Apollo. Washington, DC: NASA, 1975, p. 43-81. (NASA Spec. Rep. SP-368)]. Ground-based models, including the hindlimb-unloading model, have become important tools for increasing understanding of how spaceflight conditions can influence physiology. The objective of the present study was to determine the effect of hindlimb unloading on the susceptibility of mice to Pseudomonas aeruginosa infection. Hindlimb-unloaded and control mice were subcutaneously infected with 1 LD50 of P. aeruginosa. Survival, bacterial organ load, and antibody and corticosterone levels were compared among the groups. Hindlimb unloading had detrimental effects for infected mice. Animals in the hindlimb-unloaded group, compared with controls, 1). showed significantly increased mortality and reduced time to death, 2). had increased levels of corticosterone, and 3). were much less able to clear bacteria from the organs. These results suggest that hindlimb unloading may induce the production of corticosterone, which may play a critical role in the modulation of the immune system leading to increased susceptibility to P. aeruginosa infection.

Non-NASA Center↗

Determining Appropriate Risk Remediation Thresholds from Empirical Conjunction Data Using Survival Probability Methods

Satellites sometimes maneuver before conjunctions to remediate the risk of an on-orbit collision. Many missions use probability of collision (P(sub c)) thresholds to decide when such maneuvers should be performed. These thresholds tend to be conservative because of policies that require satellites survive their lifetimes without collision with high confidence (e.g., 99.9%). This study presents a semi-empirical method to estimate remediation P(sub c) thresholds that satisfy such lifetime risk requirements. The formulation combines survival probability analysis with empirical conjunction histories to estimate remediation thresholds as a function of satellite size, remaining on-orbit duration, lifetime collision probability limit, collision consequence, and other parameters.

Risk remediation thresholds↗

Determining Appropriate Risk Remediation Thresholds from Empirical Conjunction Data Using Survival Probability Methods

Satellites sometimes maneuver before conjunctions to remediate the risk of an on-orbit collision. Many missions use probability of collision (P_c) thresholds to decide when such maneuvers should be performed. These thresholds tend to be conservative because of policies that require satellites survive their lifetimes without collision with high confidence (e.g., 99.9%). This study presents a semi-empirical method to estimate remediation P_c thresholds that satisfy such lifetime risk requirements. The formulation combines survival probability analysis with empirical conjunction histories to estimate remediation thresholds as a function of satellite size, remaining on-orbit duration, lifetime collision probability limit, collision consequence, and other parameters.

Risk Remediation↗

Re-Entry Survivability Risk Assessment of the Extreme Ultraviolet Explorer (EUVE)

A reentry analysis of the Extreme Ultraviolet Explorer (EUVE) spacecraft was performed using the Object Reentry Survival Analysis Tool (ORSAT) - Version 5.0. The analysis was done in response to a request by NASA Headquarters and Goddard Space Flight Center (GSFC) after a preliminary assessment using the NASA Johnson Space Center Debris Assessment Software (DAS) - Version 1.0 had shown that the EUVE reentry may produce a debris area greater than the limit set within the NASA Safety Standard 1740.14 guidelines. DAS predicted that an uncontrolled reentry of the EUVE spacecraft would result in a total casualty area of 12.41 sq m, which exceeds the 8 sq m limit set in the NASA standards and implies a potential human casualty risk of approximately 1 in 5300. The ORSAT model enabled a higher fidelity thermal analysis of the EUVE spacecraft, utilizing sophisticated material and thermal properties such as emissivity, heat of oxidation, thermal conductivity, and material thickness inputs, which provided a foundation for a more in depth analysis of the reentering objects. Due to the conservative nature of the DAS study, it was reasonable to run ORSAT for only the ten objects shown to survive in the original DAS analysis. The result of the ORSAT study was a reduced casualty area of only 5.95 sq m, well within NASA safety limits. With the risk to human life now acceptably low, NASA can avoid having to take mitigation measures and allow EUVE to reenter the Earth's atmosphere uncontrolled.

O'Hara, Robin E.↗

mBAND Analysis of Late Chromosome Aberrations in Human Lymphocytes Induced by Gamma Rays and Fe Ions

Chromosomal translocations and inversions are considered stable, and cells containing these types of chromosome aberrations can survive multiple cell divisions. An efficient method to detect an inversion is multi-color banding fluorescent in situ hybridization (mBAND) which allows identification of both inter- and intrachromosome aberrations simultaneously. Post irradiation, chromosome aberrations may also arise after multiple cell divisions as a result of genomic instability. To investigate the stable or late-arising chromosome aberrations induced after radiation exposure, we exposed human lymphocytes to gamma rays and Fe ions ex vivo, and cultured the cells for multiple generations. Chromosome aberrations were analyzed in cells collected at first mitosis and at several time intervals during the culture period post irradiation. With gamma irradiation, about half of the damages observed at first mitosis remained after 7 day- and 14 day- culture, suggesting the transmissibility of damages to the surviving progeny. Detailed analysis of chromosome break ends participating in exchanges revealed a greater fraction of break ends involved in intrachromosome aberrations in the 7- and 14-day samples in comparison to the fraction at first mitosis. In particular, simple inversions were found at 7 and 14 days, but not at the first mitosis, suggesting that some of the aberrations might be formed days post irradiation. In contrast, at the doses that produced similar frequencies of gamma-induced chromosome aberrations as observed at first mitosis, a significantly lower yield of aberrations remained at the same population doublings after Fe ion exposure. At these equitoxic doses, more complex type aberrations were observed for Fe ions, indicating that Fe ion-induced initial chromosome damages are more severe and may lead to cell death. Comparison between low and high doses of Fe ion irradiation in the induction of late damages will also be discussed.

Sunagawa, Mayumi↗

Incorporating finite element analysis into component life and reliability

A method for calculating a component's design survivability by incorporating finite element analysis and probabilistic material properties was developed. The method evaluates design parameters through direct comparisons of component survivability expressed in terms of Weibull parameters. The analysis was applied to a rotating disk with mounting bolt holes. The highest probability of failure occurred at, or near, the maximum shear stress region of the bolt holes. Distribution of failure as a function of Weibull slope affects the probability of survival. Where Weibull parameters are unknown for a rotating disk, it may be permissible to assume Weibull parameters, as well as the stress-life exponent, in order to determine the disk speed where the probability of survival is highest.

August, Richard↗

Early and Late Chromosome Damages in Human Lymphocytes Induced by Gamma Rays and Fe Ions

Chromosomal translocations and inversions are considered stable, and cells containing these types of chromosome aberrations can survive multiple cell divisions. An efficient method to detect an inversion is multi-color banding fluorescent in situ hybridization (mBAND) which allows identification of both inter- and intrachromosome aberrations simultaneously. Post irradiation, chromosome aberrations may also arise after multiple cell divisions as a result of genomic instability. To investigate the stable or late-arising chromosome aberrations induced after radiation exposure, we exposed human lymphocytes to gamma rays and Fe ions ex vivo, and cultured the cells for multiple generations. Chromosome aberrations were analyzed in cells collected at first mitosis and at several time intervals during the culture period post irradiation. With gamma irradiation, about half of the damages observed at first mitosis remained after 7 day- and 14 day- culture, suggesting the transmissibility of damages to the surviving progeny. Detailed analysis of chromosome break ends participating in exchanges revealed a greater fraction of break ends involved in intrachromosome aberrations in the 7- and 14-day samples in comparison to the fraction at first mitosis. In particular, simple inversions were found at 7 and 14 days, but not at the first mitosis, suggesting that some of the aberrations might be formed days post irradiation. In contrast, at the doses that produced similar frequencies of gamma-induced chromosome aberrations as observed at first mitosis, a significantly lower yield of aberrations remained at the same population doublings after Fe ion exposure. At these equitoxic doses, more complex type aberrations were observed for Fe ions, indicating that Fe ion-induced initial chromosome damages are more severe and may lead to cell death. Comparison between low and high doses of Fe ion irradiation in the induction of late damages will also be discussed.

Sunagawa, Mayumi↗

Safety in earth orbit study. Volume 2: Analysis of hazardous payloads, docking, on-board survivability

Detailed and supporting analyses are presented of the hazardous payloads, docking, and on-board survivability aspects connected with earth orbital operations of the space shuttle program. The hazards resulting from delivery, deployment, and retrieval of hazardous payloads, and from handling and transport of cargo between orbiter, sortie modules, and space station are identified and analyzed. The safety aspects of shuttle orbiter to modular space station docking includes docking for assembly of space station, normal resupply docking, and emergency docking. Personnel traffic patterns, escape routes, and on-board survivability are analyzed for orbiter with crew and passenger, sortie modules, and modular space station, under normal, emergency, and EVA and IVA operations.

Source record↗

Experiment S010: Agena micrometeorite collection

A study was made of the micrometeoroid content of the upper atmosphere and the near-earth space environment. Highly polished collection surfaces attached to the target docking adapter (TDA) were exposed to micrometeorite impact and debris collection during the Gemini 8, 9, and 10 missions. Also, the device was attached to the Gemini Agena target vehicle (GATV) during the Gemini 12 mission. The effects of space environment exposure on viable microorganisms were recorded. No substantive data regarding space environment micrometeorite content were derived from the Gemini 9 or 12 missions. However, some substantive data were obtained from the experiment package that was retrieved from the Gemini 10 mission. The micrometeorite-flux values obtained were in general agreement with values obtained from previous experiments by the use of other experimental equipment. The microorganisms that were retrieved from the Gemini 10 experiment package did not survive. However, the same kinds of specimens inside the package had good survival rates. Upon initial analysis, it appeared that the closed-cover shielding was a contributing factor in the protection and survival of the microorganisms.

Hemenway, C. L.↗

Fatigue criterion to system design, life and reliability: A primer

A method for estimating a component's design survivability by incorporating finite element analysis and probabilistic material properties was developed. The method evaluates design parameters through direct comparisons of component survivability expressed in terms of Weibull parameters. The analysis was applied to a rotating disk with mounting bolt holes. The highest probability of failure occurred at, or near, the maximum shear stress region of the bolt holes. Distribution of material failure as a function of Weibull slope affects the probability of survival. Where Weibull parameters are unknown for a rotating disk, it may be permissible to assume Weibull parameters, as well as the stress-life exponent, in order to determine the qualitative effect of disk speed on the probability of survival.

Zaretsky, Erwin V.↗

Design/Analysis of the JWST ISIM Bonded Joints for Survivability at Cryogenic Temperatures

A major design and analysis challenge for the JWST ISIM structure is thermal survivability of metal/composite bonded joints below the cryogenic temperature of 30K (-405 F). Current bonded joint concepts include internal invar plug fittings, external saddle titanium/invar fittings and composite gusset/clip joints all bonded to M55J/954-6 and T300/954-6 hybrid composite tubes (75mm square). Analytical experience and design work done on metal/composite bonded joints at temperatures below that of liquid nitrogen are limited and important analysis tools, material properties, and failure criteria for composites at cryogenic temperatures are sparse in the literature. Increasing this challenge is the difficulty in testing for these required tools and properties at cryogenic temperatures. To gain confidence in analyzing and designing the ISIM joints, a comprehensive joint development test program has been planned and is currently running. The test program is designed to produce required analytical tools and develop a composite failure criterion for bonded joint strengths at cryogenic temperatures. Finite element analysis is used to design simple test coupons that simulate anticipated stress states in the flight joints; subsequently the test results are used to correlate the analysis technique for the final design of the bonded joints. In this work, we present an overview of the analysis and test methodology, current results, and working joint designs based on developed techniques and properties.

Bartoszyk, Andrew↗

Are You In or Out: the Influence of Sea Ice Drift on Sea Ice Survivability

The state of Arctic sea ice influences aspects of many global systems including ecosystems, economies, geopolitics, and climate. And, it is in severe decline. Numerous studies have considered the factors that influence Arctic sea ice decline using monthly mean or gridded data. However, these methods struggle to cleanly separate the influences on sea ice melt because the sea ice cover is always moving; thus, different sea ice floes and sea ice regimes constitute the monthly average sea ice state within the Eulerian frame. This study uses a LaGrangian sea ice parcel tracking satellite database to investigate the factors that influence sea ice parcel survivability. The concept of sea ice survivability is defined as the likelihood that a sea ice parcel will last through the summer melt season. Survivability can be stratified in many ways to analyze how it changes as a function of sea ice regime, region, and sea ice characteristics. How is the survivability of first year (FY) and multi-year (MY) ice classes influenced by sea ice motion? This is the central question addressed in this presentation. Specifically, this analysis determines sea ice survivability as a function of distance traveled by sea ice parcels and compares the survivability statistics for sea ice parcels that stay in their starting region versus those that leave their starting region. The preliminary results indicate that the influence of sea ice movement on survivability depends strongly on which region the sea ice resides in at the beginning of the growth season. Lastly, we find substantial inter-annual variability in the regional distribution of sea ice survivability that seems to be strongly linked to sea ice parcel drift between regions of the Arctic Ocean. Moreover, we use these results to discuss the potential contribution of changes in sea ice motion on the observed slowdown in Arctic sea ice extent loss.

Patrick C Taylor↗

Improvement of the mechanical and thermal properties of the metallized polycarbonate capacitor

Changes were studied which enable polycarbonate metallized film capacitors to withstand 500 thermal shock cycles while maintaining electrical characteristic integrity without becoming intermittent, and without losing hermeticity. The task was for metallized polycarbonate film capacitors designed to meet MIL-C-39022/9 and MIL-C-83421/1. The capacitor design improvements implemented were the insertion of a rubber washer between spray cap and end seal and the utilization of a flexible lead assembly. One hundred fifty capacitors incorporating the design improvements were manufactured and subsequently underwent 500 thermal shock cycles. One hundred forty nine capacitors survived the test. Failure analysis revealed that the lone failure was due to a poor solder joint, initially detected in pre-screening tests as having poor dissipation factor and equivalent series resistance measurement readings.

Kellerman, H. J.↗

Evidence for Changes in 81PIWild 2 Organic Matter Since Collection and Comparison of 82PIWild 2 and IDP Organic Matter to Access the Thermal Effects of Aerogel Capture

NASA s Stardust spacecraft collected cometary material during its passage through the dust coma of comet 81P/Wild 2 on January 2nd, 2004 and delivered this material to Earth on January 15th 2006. The first fragment we analyzed during the preliminary examination was partially vaporized by the X-ray beam. The carbonaceous material that survived was re-analysis approx.2 months later and the carbon spectrum for this material had significantly changed from what we first observed.. We have observed similar changes to the carbonaceous matter in some interplanetary dust particles ( IDPs). Some of the 81P/Wild 2 organic matter volatilized upon impact with the aerogel as observed using IR spectroscopy where IR spectra were collected several mms away from sample tracks [1]. The time-temperature profile experienced by any particular 81P/Wild 2 grain during aerogel capture is not known, although Brownlee, et al. suggest that fine-grained materials, <1 micron in size, fragmented and then partially vaporized during collection, while particles much larger then 1 micron in size were captured intact [2]. Nearly all organic matter is subject to thermal alteration. To assess the heating and alteration experienced by the 81P/Wild 2 organic matter during capture we are comparing 81P/Wild2 organic matter with IDP organic matter where we have evidence of heating in the IDP [3,4].

Wirick, S.↗

Haiti Agriculture: Utilizing NASA Earth Observations to Evaluate the Success of Reforestation Practices in Haiti

Haiti is one of the world’s most deforested and environmentally degraded countries. Over the past 30 years, the Haiti Reforestation Partnership (HRP) has provided resources, education, and expertise to support reforestation work in Haiti. The HRP has planted over 15 million trees through their partnership with Comprehensive Development Program (CODEP). However, they have yet to conduct a comprehensive analysis of forest stand survival. The NASA DEVELOP team partnered with the HRP to aid their future silvicultural decisions using satellite imagery. Through the creation of the Monitoring of Vegetation Presence (MVP) tool in Google Earth Engine, the team produced a time series showing trends in enhanced vegetation index (EVI) from 1984 to 2021, as well as a habitat suitability map using a general model for all tree species. These provided the partner with visuals to communicate their reforestation efforts and guidance on where to apply their future efforts. The team utilized Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper Plus (ETM+), Landsat 8 Operational Land Imager (OLI), Landsat 9 OLI-2 and Sentinel-2 Multispectral Instrument (MSI) vegetation indices as indicators of stand success over time. The team also incorporated WorldClim bioclimatic variables such as precipitation and temperature, Centre National de L’Information Geo-Spatiale (CNIGS) Airborne Lidar elevation, and ancillary datasets areas suitable for future reforestation efforts. Overall, the time series showed that the demonstration forest increased in EVI at a greater rate than the surrounding area and the habitat model suggested there are 49,000 hectares of suitable habitat for planting using slope, aspect and temperature as predictor variables.

Kelli Roberts↗