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It has been estimated that on a 1-year mission, a four-astronaut crew will produce approximately 2,600 kg of waste materials. The current International Space Station practice for waste management is a stow and jettison model in which the trash is simply ejected. The immediate challenge waste poses for long duration space flight is that it represents unproductive mass. Longer term, waste accumulation on planetary surfaces will also pose challenges. A waste management/disposal solution is greatly needed. Simultaneously, significant research and development efforts are being made to enable in-situ resource extraction and recovery for lunar and Mars surface operations. A waste management solution could free up volume, reduce mass and thereby propellant needs, as well as contribute to resource recovery for spacecraft, and eventually, surface operations. The adaptation of many chemical engineering unit operations to the microgravity environment is critical to achieve this goal. An ideal spacecraft waste treatment system would convert waste into useful gases. It should be largely self-sustaining in that it should have the ability to recycle commodities to avoid imposing mass penalties associated with transporting feedstock on the spacecraft at launch. At NASA KSC, a model of what such a system would look like is being developed. In addition, the team has recently completed a suborbital flight campaign with a combustion reactor to demonstrate rudimentary conversion in a microgravity environment and identify challenges for future design. This presentation will discuss what a full waste treatment system could look like, point out challenges relating to various unit operations involved in such a system, and highlight recent progress in space waste management research and development.