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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
NASA NTRS2005

Tissue Engineering Using Transfected Growth-Factor Genes

A method of growing bioengineered tissues includes, as a major component, the use of mammalian cells that have been transfected with genes for secretion of regulator and growth-factor substances. In a typical application, one either seeds the cells onto an artificial matrix made of a synthetic or natural biocompatible material, or else one cultures the cells until they secrete a desired amount of an extracellular matrix. If such a bioengineered tissue construct is to be used for surgical replacement of injured tissue, then the cells should preferably be the patient s own cells or, if not, at least cells matched to the patient s cells according to a human-leucocyteantigen (HLA) test. The bioengineered tissue construct is typically implanted in the patient's injured natural tissue, wherein the growth-factor genes enhance metabolic functions that promote the in vitro development of functional tissue constructs and their integration with native tissues. If the matrix is biodegradable, then one of the results of metabolism could be absorption of the matrix and replacement of the matrix with tissue formed at least partly by the transfected cells. The method was developed for articular chondrocytes but can (at least in principle) be extended to a variety of cell types and biocompatible matrix materials, including ones that have been exploited in prior tissue-engineering methods. Examples of cell types include chondrocytes, hepatocytes, islet cells, nerve cells, muscle cells, other organ cells, bone- and cartilage-forming cells, epithelial and endothelial cells, connective- tissue stem cells, mesodermal stem cells, and cells of the liver and the pancreas. Cells can be obtained from cell-line cultures, biopsies, and tissue banks. Genes, molecules, or nucleic acids that secrete factors that influence the growth of cells, the production of extracellular matrix material, and other cell functions can be inserted in cells by any of a variety of standard transfection techniques.

Madry, Henning↗
NASA NTRS1974

Effects of positive acceleration /+Gz/ on renal function and plasma renin in normal man

The effects of positive radial centrifugation (+Gz) on plasma resin activity (PRA) and renal function were assessed in 15 normal male subjects under carefully controlled conditions of Na, K, and water intake. Twenty minutes of +2.0 Gz resulted in significant decreases in the mean rate of sodium excretion and creatine clearance and in a doubling of PRA in seven sodium-depleted subjects (10 meq Na intake). In eight sodium-replete subjects (200 mq Na intake), 30 min of +2.0 Gz was also associated with a decrease in the mean rate of sodium excretion. As a consequence of a concurrent decrease in creatine clearance, the fractional excretion of sodium during centrifugation did not differ from control, suggesting that the changes in Na excretion were mediated primarily by renal hemodynamic factors, although enhanced renal tubular sodium reabsorption may also have played a role.

Epstein, M.↗
NASA NTRS1980

Scratch encourages selective doping

Dislocations induced by scratching produce deep narrow spikes of zinc diffused in gallium arsenide. Density of defects formed locally increases zinc diffusion coefficient. Enhancements by factor of 6 have been observed. Technique works for other dopants than zinc and for other semiconductors besides GaAs.

Hawrylo, F. Z.↗
NASA NTRS1981

The abundance of argon at the galactic center

Measurements of forbidden line Ar II 6.99 micron and Pf alpha 7.45 micron made from the Kuiper Airborne Observatory are presented for Sgr A, the H II region at the center of the Galaxy. These line strengths, when combined with ground-based measurements, suggest a factor of enhancement of two in the Ar/H ratio in the galactic center region relative to that in the sun and in the solar neighborhood. The accuracy of the determination is presently limited by the uncertainty in the collision strength for Ar(+).

Lester, D. F.↗
NASA NTRS1981

Use of software tools in the development of real time software systems

The transformation of a preexisting software system into a larger and more versatile system with different mission requirements is discussed. The history of this transformation is used to illustrate the use of structured real time programming techniques and tools to produce maintainable and somewhat transportable systems. The predecessor system is a single ground diagnostic system; its purpose is to exercise a computer controlled hardware set prior to its deployment in its functional environment, as well as test the equipment set by supplying certain well known stimulas. The successor system (FTE) is required to perform certain testing and control functions while this hardware set is in its functional environment. Both systems must deal with heavy user input/output loads and a new I/O requirement is included in the design of the FTF system. Human factors are enhanced by adding an improved console interface and special function keyboard handler. The additional features require the inclusion of much new software to the original set from which FTF was developed. As a result, it is necessary to split the system into a duel programming configuration with high rates of interground communications. A generalized information routing mechanism is used to support this configuration.

Garvey, R. C.↗
NASA NTRS1987

Group-level issues in the design and training of cockpit crews

Cockpit crews always operate in an organizational context, and the transactions between the crew and representatives of that context (e.g., organizational managers, air traffic controllers) are consequential for any crew's performance. For a complete understanding of crew performance a look beyond the traditional focus on individual pilots is provided to see how team- and organization-level factors can enhance (or impede) the ability of even well-trained individuals to work together effectively. This way of thinking about cockpit crews (that is, viewing them as teams that operate in organizations) offers some potentially useful avenues for thinking about next steps in the development of CRM training programs. Those possibilities are explored, emphasizing how they can enrich (not replace) individually-focussed CRM training.

Hackman, J. Richard↗
NASA NTRS1989

Erosive burning threshold conditions in solid rocket motors

Erosive burning has been predicted to be enhanced by factors that increase the level of turbulence close to the propellant surface, such a high cross flow velocity, low surface blowing rate, propellant surface roughness, and adverse pressure gradient. A study is reported which was carried out with the objective of measuring the effects of these parameters on the scaling to larger rocket motor sizes of the transition to, or threshold conditions for, erosive burning rate augmentation. The results are used to develop a scaling criterion for the threshold conditions for erosive burning.

Strand, L. D.↗
NASA NTRS1990

Microstructure and mechanical properties of multiphase NiAl-based alloys

The effect of the gamma-prime phase on the deformation behavior and fracture resistance of melt-spun ribbons and consolidated bulk specimens of a series of Nial-based alloys with Co and Hf additions has been examined. The morphology, location, and volume fraction of the gamma-prime phase are significant factors in enhancing the fracture resistance of the normally brittle NiAl-based alloys. In particular, the results indicate that a continuous-grain-boundary film of gamma-prime can impart limited room-temperature ductility regardless of whether B2 or L10 NiAl is present. Guidelines for microstructure control in multiphase NiAl-based alloys are also presented.

Pank, D. R.↗
NASA NTRS1991

Relationships between CH4 emission, biomass, and CO2 exchange in a subtropical grassland

Methane flux was linearly correlated with plant biomass (r = 0.97, n = 6 and r = 0.95, n = 8) at two locations in a Florida Everglades Cladium marsh. One location, which had burned 4 months previously, exhibited a greater increase in methane flux as a function of biomass relative to sites at an unburned location. However, methane flux data from both sites fit a single regression (r = 0.94, n = 14) when plotted against net CO2 exchange suggesting that either methanogenesis in Everglades marl sediments is fueled by root exudation below ground, or that factors which enhance photosynthetic production and plant growth are also correlated with methane production and flux in this oligotrophic environment. The data presented are the first to show a direct relationship between spatial variability in plant biomass, net ecosystem production, and methane emission in a natural wetland.

Whiting, Gary J.↗
NASA NTRS1992

Infrared spectral measurement of Space Shuttle glow

The USAF and NASA successfully conducted infrared spectral measurements of the Space Shuttle glow during STS-39. Preliminary analysis indicates that NO, NO(+), OH, and CO produce infrared glow during quiescent orbiter conditions. During orbiter thruster firings the glow intensities in the infrared are enhanced by factors of 10X and 100X with significant changes in spectral distribution. These measurements were obtained with the Spacecraft Kinetic Infrared Test payload which included a cryogenic infrared circular variable filter infrared spectrometer covering the 0.7 to 5.4 microns wavelength region. Approximately 14,000 spectra of Shuttle glow, airglow, aurora, and the orbiter environment were obtained during the eight day mission. The STS-39 Space Shuttle Discovery was launched from the NASA Kennedy Space Center on 28 April, 1991 into a 57-deg inclination circular orbit at an altitude of 260 km.

Ahmadjian, Mark↗
NASA NTRS1992

Outer heliospheric radio emissions. II - Foreshock source models

Observations of LF radio emissions in the range 2-3 kHz by the Voyager spacecraft during the intervals 1983-1987 and 1989 to the present while at heliocentric distances greater than 11 AU are reported. New analyses of the wave data are presented, and the characteristics of the radiation are reviewed and discussed. Two classes of events are distinguished: transient events with varying starting frequencies that drift upward in frequency and a relatively continuous component that remains near 2 kHz. Evidence for multiple transient sources and for extension of the 2-kHz component above the 2.4-kHz interference signal is presented. The transient emissions are interpreted in terms of radiation generated at multiples of the plasma frequency when solar wind density enhancements enter one or more regions of a foreshock sunward of the inner heliospheric shock. Solar wind density enhancements by factors of 4-10 are observed. Propagation effects, the number of radiation sources, and the time variability, frequency drift, and varying starting frequencies of the transient events are discussed in terms of foreshock sources.

Cairns, Iver H.↗
NASA NTRS1994

Remarkable long-term changes in the small Magellanic Cloud Wolf-Rayet system HD 5980

In this paper we report the remarkable changes which occured in the Small Magellanic Cloud W-R system HD5980 = AB5 between 1978 and 1991. Within this timescale, there has been a systematic enhancement (by factors of 2-10 depending on the line) in the equivalent widths of all emission lines, and a change in the relative strengths of N III, N IV, and N V lines. Currently, the W-R spectrum is more typical of a WN6 star than a WN3 or WN4, as it was originally classified. The terminal speed of the wind has diminished by approximately 600 km/s, while the system has brightened in the visual by 0.45 mag. The UV (1850 A) continuum changed by less than 0.13 mag. The change from WN3 or WN4 to WN6 is unprecedented. The system appears to be composed at least three stars: two WNs in mutual 19.266 day orbit and an O-type supergiant. We propose that the changes observed in HD 5980 are related to an increase in wind density of one (or both?) of the W-R components, where the brighter WN6 component will dominate the W-R spectrum after the change, and we speculate that this modification of the wind structure is driven by tidal interaction induced by a possible current periastron passage of the third component in the system.

Koenigsberger, G.↗
NASA NTRS1996

The high-latitude cloud MBM 7. I. H I and CO observations

The high-latitude cloud (HLC) MBM 7 has been observed in the 21 cm H I line and the 12CO(1-0) and 13CO(1-0) lines with similar spatial resolutions. The data reveal a total mass approximately 30 M solar for MBM 7 and a complex morphology. The cloud consists of a cold dense core of 5 M solar surrounded by atomic and molecular gas with about 25 M solar, which is embedded in hotter and more diffuse H I gas. We derive a total column density N(H I + 2H2) of 1 x 10(21) cm-2 toward the center and 1 x 10(20) cm-3 toward the envelope of MBM 7. The CO line indicates the existence of dense cores [n(H2) > or = 2000 cm-3] of size (FWHM) approximately 0.5 pc. The morphology suggests shock compression from the southwest direction, which can form molecular cores along the direction perpendicular to the H I distribution. The H I cloud extends to the northeast, and the velocity gradient appears to be about 2.8 km s-1 pc-1 in this direction, which indicates a systematic outward motion which will disrupt the cloud in approximately 10(6) yr. The observed large line widths of approximately 2 km s-1 for CO suggest that turbulent motions exist in the cloud, and hydrodynamical turbulence may dominate the line broadening. Considering the energy and pressure of MBM 7, the dense cores appear not to be bound by gravity, and the whole cloud including the dense cores seem to be expanding. The distance to HLCs suggest that they belong to the galactic plane, since the scale height of the cloud is < or approximately equal to 100 pc. Compared to the more familiar dense dark clouds, HLCs may differ only in their small mass and low density, with their proximity reducing the filling factor and enhancing the contrast of the core and envelope structure.

Non-NASA Center↗
NASA NTRS1993

Observations of C3H2 (2(12) - 1(01)) toward the Sagittarius A molecular cloud

We have mapped the C3H2 2(12)-1(01) transition line toward the Sgr A molecular cloud on a 1' grid spacing and derived C3H2 column densities of 3 approximately 7 x 10(14) cm-2 for molecular clouds of Sgr A. The fractional abundances of C3H2 relative to H2 are obtained to be 3 approximately 6 x 10(-9), which are slightly lower than that for the cold dark cloud TMC-1 but are enhanced by factors of 5-60 compared to those for Sgr B2 and the Orion extended ridge. We also estimate from the C3H2 column densities total masses of approximately 10(6) M(solar) for two clouds (M - 0.13-0.08 and M - 0.02-0.07), which are thought to be close to the virial equilibrium. We suggest that the large abundance of C3H2 in Sgr A may be partly due to the activities of the Galactic center.

Non-NASA Center↗
NASA NTRS1995

Selectivity of end-Cretaceous marine bivalve extinctions

Analyses of the end-Cretaceous or Cretaceous-Tertiary mass extinction show no selectivity of marine bivalve genera by life position (burrowing versus exposed), body size, bathymetric position on the continental shelf, or relative breadth of bathymetric range. Deposit-feeders as a group have significantly lower extinction intensities than suspension-feeders, but this pattern is due entirely to low extinction in two groups (Nuculoida and Lucinoidea), which suggests that survivorship was not simply linked to feeding mode. Geographically widespread genera have significantly lower extinction intensities than narrowly distributed genera. These results corroborate earlier work suggesting that some biotic factors that enhance survivorship during times of lesser extinction intensities are ineffectual during mass extinctions.

NASA Discipline Exobiology↗
NASA NTRS2008

Trajectory Planning by Preserving Flexibility: Metrics and Analysis

In order to support traffic management functions, such as mitigating traffic complexity, ground and airborne systems may benefit from preserving or optimizing trajectory flexibility. To help support this hypothesis trajectory flexibility metrics have been defined in previous work to represent the trajectory robustness and adaptability to the risk of violating safety and traffic management constraints. In this paper these metrics are instantiated in the case of planning a trajectory with the heading degree of freedom. A metric estimation method is presented based on simplifying assumptions, namely discrete time and heading maneuvers. A case is analyzed to demonstrate the estimation method and its use in trajectory planning in a situation involving meeting a time constraint and avoiding loss of separation with nearby traffic. The case involves comparing path-stretch trajectories, in terms of adaptability and robustness along each, deduced from a map of estimated flexibility metrics over the solution space. The case demonstrated anecdotally that preserving flexibility may result in enhancing certain factors that contribute to traffic complexity, namely reducing proximity and confrontation.

Idris, Husni R.↗
NASA NTRS2011

High aspect ratio template and method for producing same for central and peripheral nerve repair

Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompatible matrixes may be formed with long pore length and small pore size. The manufacturing process begins with a first polymer fiber arranged in a matrix formed by a second polymer fiber. End caps may be attached to provide structural support and the polymer fiber matrix selectively dissolved away leaving only the long polymer fibers. These may be exposed to another product, such as a biocompatible gel to form a biocompatible matrix. The polymer fibers may then be selectively dissolved leaving only a biocompatible gel scaffold with the pores formed by the dissolved polymer fibers. The scaffolds may be used in, among other applications, the repair of central and peripheral nerves. Scaffolds for the repair of peripheral nerves may include a reservoir for the sustained release of nerve growth factor. The scaffolds may also include a multifunctional polyelectrolyte layer for the sustained release of nerve growth factor and enhance biocompatibility.

Sakamoto, Jeff S.↗
NASA NTRS2013

Preindustrial to Present-Day Changes in Tropospheric Hydroxyl Radical and Methane Lifetime from the Atmospheric Chemistry and Climate Model Intercomparison Project (ACCMIP)

We have analysed time-slice simulations from 17 global models, participating in the Atmospheric Chemistry and Climate Model Intercomparison Project (ACCMIP), to explore changes in present-day (2000) hydroxyl radical (OH) concentration and methane (CH4) lifetime relative to preindustrial times (1850) and to 1980. A comparison of modeled and observation-derived methane and methyl chloroform lifetimes suggests that the present-day global multi-model mean OH concentration is overestimated by 5 to 10% but is within the range of uncertainties. The models consistently simulate higher OH concentrations in the Northern Hemisphere (NH) compared with the Southern Hemisphere (SH) for the present-day (2000; inter-hemispheric ratios of 1.13 to 1.42), in contrast to observation-based approaches which generally indicate higher OH in the SH although uncertainties are large. Evaluation of simulated carbon monoxide (CO) concentrations, the primary sink for OH, against ground-based and satellite observations suggests low biases in the NH that may contribute to the high north–south OH asymmetry in the models. The models vary widely in their regional distribution of present-day OH concentrations (up to 34%). Despite large regional changes, the multi-model global mean (mass-weighted) OH concentration changes little over the past 150 yr, due to concurrent increases in factors that enhance OH (humidity, tropospheric ozone, nitrogen oxide (NOx) emissions, and UV radiation due to decreases in stratospheric ozone), compensated by increases in OH sinks (methane abundance, carbon monoxide and non-methane volatile organic carbon (NMVOC) emissions). The large inter-model diversity in the sign and magnitude of preindustrial to present-day OH changes (ranging from a decrease of 12.7% to an increase of 14.6%) indicate that uncertainty remains in our understanding of the long-term trends in OH and methane lifetime. We show that this diversity is largely explained by the different ratio of the change in global mean tropospheric CO and NOx burdens (Delta CO/Delta NOx, approximately represents changes in OH sinks versus changes in OH sources) in the models, pointing to a need for better constraints on natural precursor emissions and on the chemical mechanisms in the current generation of chemistry-climate models. For the 1980 to 2000 period, we find that climate warming and a slight increase in mean OH (3.5 +/- 2.2%) leads to a 4.3 +/- 1.9% decrease in the methane lifetime. Analysing sensitivity simulations performed by 10 models, we find that preindustrial to present-day climate change decreased the methane lifetime by about four months, representing a negative feedback on the climate system. Further, we analysed attribution experiments performed by a subset of models relative to 2000 conditions with only one precursor at a time set to 1860 levels. We find that global mean OH increased by 46.4 +/- 12.2% in response to preindustrial to present-day anthropogenic NOx emission increases, and decreased by 17.3 +/-2.3%, 7.6 +/- 1.5%, and 3.1 +/- 3.0% due to methane burden, and anthropogenic CO, and NMVOC emissions increases, respectively.

nitrogen oxides↗