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Results for “Determination and Control”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 127 records · Page 7
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

Structural basis for self-discrimination by neoantigen-specific TCRs

T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of neoAg from somatic mutations is a major focus of current research. However, the structural and cellular determinants controlling TCR recognition of neoAgs remain poorly understood. This study describes the multi-level analysis of a model neoAg from the B16F10 murine melanoma, H2-D b /Hsf2 p.K72N 68-76 , as well as its cognate TCR 47BE7. Through cellular, molecular and structural studies we demonstrate that the p.K72N mutation enhances H2-D b binding, thereby improving cell surface presentation and stabilizing the TCR 47BE7 epitope. Furthermore, TCR 47BE7 exhibited high functional avidity and selectivity, attributable to a broad, stringent, binding interface enabling recognition of native B16F10 despite low antigen density. Our findings provide insight into the generation of anchor-residue modified neoAg, and emphasize the value of molecular and structural investigations of neoAg in diverse MHC-I contexts for advancing the understanding of neoAg immunogenicity.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Terrestrial carbon dynamics in an era of increasing wildfire

In an increasingly flammable world, wildfire is altering the terrestrial carbon balance. However, the degree to which novel wildfire regimes disrupt biological function remains unclear. Here, we synthesize the current understanding of above and below ground processes that govern carbon loss and recovery across diverse ecosystems. In this study, we find that intensifying wildfire regimes are increasingly exceeding biological thresholds of resilience, causing ecosystems to convert to a lower carbon-carrying capacity. Growing evidence suggests that plants compensate for fire damage by allocating carbon below ground to access nutrients released by fire, while wildfire selects for microbial communities with rapid growth rates and the ability to metabolize pyrolyzed carbon. Determining controls on carbon dynamics following wildfire requires integration of experimental and modeling frameworks across scales and ecosystems. Fire severity is expected to increase as a result of warming. This will potentially amplify climate change due to its impact on the carbon cycle. This Review discusses ecosystem carbon loss and recovery following wildfire, and highlights where further work is needed to inform model predictions.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1967

A calibration means for spectrum analyzers

Spectrum analyzer calibration system is rapid and provides an accurate family of adjustable markers at any point in the spectrum. Pulse width controls determine the number of markers. The unit operates with a repetition rate from 300 cps to 40 kc at a center frequency from 10 kc to 2 Mc.

Larson, M. S.↗
NASA NTRS1975

Quantitative analysis of regional myocardial performance in coronary artery disease

Findings from a group of subjects with significant coronary artery stenosis are given. A group of controls determined by use of a quantitative method for the study of regional myocardial performance based on the frame-by-frame analysis of biplane left ventricular angiograms are presented. Particular emphasis was placed upon the analysis of wall motion in terms of normalized segment dimensions, timing and velocity of contraction. The results were compared with the method of subjective assessment used clinically.

Stewart, D. K.↗
NASA NTRS1978

Flight Mechanics/Estimation Theory Symposium

Satellite attitude determination and control, orbit determination, and onboard and ground attitude determination procedures are among the topics discussed. Other topics covered include: effect of atmosphere on Venus orbiter navigation; satellite-to-satellite tracking; and satellite onboard navigation using global positioning system data.

Source record↗
NASA NTRS1978

Diode step stress program, JANTX1N5614

The reliability of switching diode JANTX1N5614 was tested. The effect of power/temperature step stress on the diode was determined. Control sample units were maintained for verification of the electrical parametric testing. Results are reported.

Source record↗
NASA NTRS1978

Diode step stress program, JANTX1N981B

Power/temperature step stress was applied to the Zener diode JANTX1N981B. Reliability of the device was determined. Control units were maintained for verification of the electrical parametric testing. Results are reported.

Source record↗
NASA NTRS1982

A prescribed wake rotor inflow and flow field prediction analysis, user's manual and technical approach

A user's manual is provided which includes the technical approach for the Prescribed Wake Rotor Inflow and Flow Field Prediction Analysis. The analysis is used to provide the rotor wake induced velocities at the rotor blades for use in blade airloads and response analyses and to provide induced velocities at arbitrary field points such as at a tail surface. This analysis calculates the distribution of rotor wake induced velocities based on a prescribed wake model. Section operating conditions are prescribed from blade motion and controls determined by a separate blade response analysis. The analysis represents each blade by a segmented lifting line, and the rotor wake by discrete segmented trailing vortex filaments. Blade loading and circulation distributions are calculated based on blade element strip theory including the local induced velocity predicted by the numerical integration of the Biot-Savart Law applied to the vortex wake model.

Egolf, T. A.↗
NASA NTRS1985

Surface Structures of Hawaiian Lavas

Surface and internal lava structures can be valid indicators of lava viscosity and rheology, provided that care is taken to identify and eliminate structures which are strain-rate-dependent. Here, a spectrum of types among Hawaiian basaltic flows is found ranging from pahoehoe to a'a, that are interpreted as marking a progression in lava viscosity and a change in rheology. The most fluid type in this spectrum is normal pahoehoe that has a smooth but commonly wrinkled or folded (ropy) surface. The next type, distinctly more viscous and probably non-Newtonian in rheology, is spiny pahoehoe which is characterized by a spinose surface and an absence of ropy structures. Preliminary studies on the long lavas of Mauna Loa indicated, perhaps surprisingly, that there is no clear-cut correlation of lava length with type in this spectrum of lavas, indicating that viscosity/yield strength of the basaltic lavas per se are not the primary controls determining flow length. Flowage of the lava through lava tubes, while it may help to account for the long flow distance of some lavas, is not a generally applicable explanation for long flow length.

Rowland, S. K.↗
NASA NTRS1985

Optimal flight paths through microburst wind profiles

The problem of safe microburst wind shear encounter during the approach and climb-out flight phases is addressed using flight path optimization. The purpose was to investigate the physical limits of safe penetration and to determine control strategies that take full advantage of those limits. Optimal trajectories for both jet transport and general aviation aircraft were computed for encounters with idealized and actual microburst profiles. The results demonstrate that limits to control system design rather than to the aircraft's physical performance may be the deciding factor in an aircraft's capability for safe passage through a wide class of microbursts. The best control strategies responded to airspeed loss in an unconventional manner: by raising the nose to maintain lift.

Psiaki, M. L.↗
NASA NTRS1987

Microprocessor-Based Valved Controller

New controller simpler, more precise, and lighter than predecessors. Mass-flow controller compensates for changing supply pressure and temperature such as occurs when gas-supply tank becomes depleted. By periodically updating calculation of mass-flow rate, controller determines correct new position for valve and keeps mass-flow rate nearly constant.

Norman, Arnold M., Jr.↗
NASA NTRS1987

A modular BLSS simulation model

A bioregenerative life support system (BLSS) for extraterrestrial use will be faced with coordination problems more acute than those in any ecosystem found on Earth. A related problem in BLSS design is providing an interface between the various life support processors, one that will allow for their coordination while still allowing for system expansion. A modular model is presented of a BLSS that interfaces system processors only with the material storage reservoirs, allowing those reservoirs to act as the principal buffers in the system and thus minimizing difficulties with processor coordination. The modular nature of the model allows independent development of the detailed submodels that exist within the model framework. Using this model, BLSS dynamics were investigated under normal conditions and under various failure modes. Partial and complete failures of various components, such as the waste processors or the plants themselves, drive transient responses in the model system, allowing the examination of the effectiveness of the system reservoirs as buffers. The results from simulations help to determine control strategies and BLSS design requirements. An evolved version could be used as an interactive control aid in a future BLSS.

Rummel, John D.↗
NASA NTRS1987

A modular BLSS simulation model

The coordination of material flows in earth's biosphere is largely made possible by the buffering effect of huge material reservoirs. Without similarly-sized buffers, a bioregenerative life support system (BLSS) for extraterrestrial use will be faced with coordination problems more acute than those in any ecosystem found on earth. A related problem in BLSS design is providing an interface between the various life-support processors, one that will allow for their coordination while still allowing for system expansion. A modular model is presented of a BLSS that interfaces system processors only with the material storage reservoirs, allowing those reservoirs to act as the principal buffers in the system and thus minimizing difficulties with processor coordination. The modular nature of the model allows independent development of the detailed submodels that exist within the model framework. Using this model, BLSS dynamics were investigated under normal conditions and under various failure modes. Partial and complete failures of various components, such as the waste processor or the plants themselves, drive transient responses in the model system, allowing examination of the effectiveness of the system reservoirs as buffers. The results from simulations of this sort will help to determine control strategies and BLSS design requirements. An evolved version of this model could be used as an interactive control aid in a future BLSS.

Rummel, John D.↗