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At least 1,315 records · Page 73

Evaluating the Impact of AIRS Observations on Regional Forecasts at the SPoRT Center

NASA Short-term Prediction Research and Transition (SPoRT) Center collaborates with operational partners of different sizes and operational goals to improve forecasts using targeted projects and data sets. Modeling and DA activities focus on demonstrating utility of NASA data sets and capabilities within operational systems. SPoRT has successfully assimilated the Atmospheric Infrared Sounder (AIRS) radiance and profile data. A collaborative project is underway with the Joint Center for Satellite Data Assimilation (JCSDA) to use AIRS profiles to better understand the impact of AIRS radiances assimilated within Gridpoint Statistical Interpolation (GSI) in hopes of engaging the operational DA community in a reassessment of assimilation methodologies to more effectively assimilate hyperspectral radiances.

Zavodsky, Bradley↗

NASA’s Developments in Cryogenic Fluid Management Technology

NASA has been pursuing the development and demonstration of enabling and enhancing technologies for Cryogenic Fluid Management (CFM) in collaboration with the US industry. NASA’s vision for current and future space exploration requires high-performance chemical and nuclear propulsion solutions that utilize cryogens. The Agency will use cryogenic fluids for Earth-to-orbit transportation, human missions to the Moon and Mars, planetary exploration, and in-situ resource utilization (ISRU) production. All these architectures will require state-of-the-art long-duration storage on the surface and in-space transfer for refueling. This paper focuses on key CFM technology developments completed or ongoing by the Cryogenic Fluid Management Portfolio Office within NASA’s Space Technology Mission Directorate. The CFM Portfolio Office, partnered with US aerospace industry, has invested in CFM technology ground and flight demonstrations, focused on maturing CFM hardware and operations for Artemis and Moon to Mars activities. These demonstrations additionally provide NASA with data to inform numerical modeling activities for verification and validation of design tools and approaches for future missions. This paper includes discussion on remaining high-priority open CFM technology gaps for Mar-forward architectures and initiatives for closure.

Cryogenic Fluid Management↗

Data & Reasoning Fabric (DRF) Outreach

The Data & Reasoning Fabric activity, under the Convergent Aeronautics Solutions (CAS) Project has developed images and content suitable for public outreach. Content and images are expected to be presented to National League of Cities, US Ignite, Association for Unmanned Vehicle Systems International (AUVSI), Federal Aviation Administration (FAA), cities, and local governments.

Data & Reasoning Fabric↗

The CMS RPC system readiness for LHC Run-3 data taking

During Run-3, the LHC is preparing to deliver instantaneous luminosity in the range from 5 × 10 34 cm -2 s -1 to 7.5 × 10 34 cm -2 s -1 . To ensure stable data taking, providing redundant information for robust muon triggering, reconstruction and identification, the CMS RPC collaboration has used the opportunity given by the LHC long shutdown 2 (LS2), to perform a series of maintenance and preparation activities for the new data taking period. The overall performance of the RPC system after the LS2 commissioning period and the activities in preparation for future data taking will be presented.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Pooling the resources of the CMS Tier-1 sites

The CMS experiment at the LHC relies on 7 Tier-1 centres of the WLCG to perform the majority of its bulk processing activity, and to archive its data. During the first run of the LHC, these two functions were tightly coupled as each Tier-1 was constrained to process only the data archived on its hierarchical storage. This lack of flexibility in the assignment of processing workflows occasionally resulted in uneven resource utilisation and in an increased latency in the delivery of the results to the physics community.The long shutdown of the LHC in 2013-2014 was an opportunity to revisit this mode of operations, disentangling the processing and archive functionalities of the Tier-1 centres. The storage services at the Tier-1s were redeployed breaking the traditional hierarchical model: each site now provides a large disk storage to host input and output data for processing, and an independent tape storage used exclusively for archiving. Movement of data between the tape and disk endpoints is not automated, but triggered externally through the WLCG transfer management systems.With this new setup, CMS operations actively controls at any time which data is available on disk for processing and which data should be sent to archive. Thanks to the high-bandwidth connectivity guaranteed by the LHCOPN, input data can be freely transferred between disk endpoints as needed to take advantage of free CPU, turning the Tier-1s into a large pool of shared resources. The output data can be validated before archiving them permanently, and temporary data formats can be produced without wasting valuable tape resources. Lastly, the data hosted on disk at Tier-1s can now be made available also for user analysis since there is no risk any longer of triggering chaotic staging from tape.In this contribution, we describe the technical solutions adopted for the new disk and tape endpoints at the sites, and we report on the commissioning and scale testing of the service. We detail the procedures implemented by CMS computing operations to actively manage data on disk at Tier-1 sites, and we give examples of the benefits brought to CMS workflows by the additional flexibility of the new system.

96 KNOWLEDGE MANAGEMENT AND PRESERVATION↗

INL Fleet Vehicle Characterization Study for the U.S. Department of Navy

Battelle Energy Alliance, LLC, managing and operating contractor for the U.S. Department of Energy’s Idaho National Laboratory, is the lead laboratory for U.S. Department of Energy Advanced Vehicle Testing. Battelle Energy Alliance, LLC collected and evaluated data on federal fleet operations as part of the Advanced Vehicle Testing Activity’s Federal Fleet Vehicle Data Logging and Characterization Study. The Advanced Vehicle Testing Activity’s study seeks to collect and evaluate data to validate use of advanced plug-in electric vehicle (PEV) transportation. This report focuses on US Department of Navy's fleet to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agency’s fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a battery electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.

33 ADVANCED PROPULSION SYSTEMS↗

Expanding on Successful Concepts, Models, and Organization

In her letter to the editor1 regarding our recent Feature Article “Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework” 2, Dr. von Göetz expressed several concerns about terminology, and the perception that we propose the replacement of successful approaches and models for exposure assessment with a concept. We are glad to have the opportunity to address these issues here. If the goal of the AEP framework was to replace existing exposure models or databases for organizing exposure data with a concept, we would share Dr. von Göetz concerns. Instead, the outcome we promote is broader use of an organizational framework for exposure science. The framework would support improved generation, organization, and interpretation of data as well as modeling and prediction, not replacement of models. The field of toxicology has seen the benefits of wide use of one or more organizational frameworks (e.g., mode and mechanism of action, adverse outcome pathway). These frameworks influence how experiments are designed, data are collected, curated, stored and interpreted and ultimately how data are used in risk assessment. Exposure science is poised to similarly benefit from broader use of a parallel organizational framework, which Dr. von Göetz correctly points out, is currently used in the exposure modeling community. In our view, the concepts used so effectively in the exposure modeling community, expanded upon in the AEP framework, could see wider adoption by the field as a whole. The value of such a framework was recognized by the National Academy of Sciences.3 Replacement of models, databases, or any application with the AEP framework was not proposed in our article. The positive role broader more consistent use of such a framework might have in enabling and advancing “general activities such as data acquisition, organization…,” and exposure modeling was discussed in some detail. Like Dr. von Göetz, we recognized the challenges associated with acceptance of the terminology, definitions, and structure proposed in the paper. To address these challenges, an expert workshop was held in May, 2016 to consider and revise the “basic elements” outlined in the paper. The attendees produced revisions to the terminology (e.g., key events) that align with terminology currently in use in the field. We were also careful in our paper to acknowledge a point raised by Dr. von Göetz, that the term AEP implies aggregation, providing these clarifications: “The simplest form of an AEP represents a single source and a single pathway and may more commonly be referred to as an exposure pathway,”; and “An aggregate exposure pathway may represent multiple sources and transfer through single pathways to the TSE, single sources and transfer through multiple pathways to the target site exposure (TSE), or any combination of these.” These clarifications address the concern that the AEP term is not accurate or logical, and further expands upon the word “aggregate” in a broader context. Our use of AEP is consistent with the definition for “aggregate exposure”, which refers to the combined exposures to a single chemical across multiple routes and pathways.3 The AEP framework embraces existing methods for collection, prediction, organization, and interpretation of human and ecological exposure data cited by Dr. von Göetz. We remain hopeful that wider recognition and use of an organizing concept for exposure information across the exposure science, toxicology and epidemiology communities advances the development of the kind of infrastructure and models Dr. von Göetz discusses. This outcome would be a step forward, rather than a step backward.

exposure science↗

Increasing Data Discovery and Re-Use: The Space Life Sciences Ontology

Two of the most important goals of the adoption of the FAIR principles are increasing the ability of agents to find and re-use research data. Achieving these goals for space life sciences research is even more pressing, given the relatively expensive and scarce nature of these data. We have reported in the past on the progress made by exemplar life sciences data systems towards implementing FAIR, showing gaps particularly in the “interoperability area” of the principles; the lack of common conceptual models for space life science research is one reason for this gap. There were few available resources that define, annotate, categorize or otherwise relate various kinds of metadata describing the acquisition, nature, and intent of investigational space life sciences data. To address this gap, NASA is working with the Open Biological and Biomedical Ontology Foundry (https://obofoundry.org/) to develop the Space Life Science Ontology (SLSO) that is intended to support archival and other kinds of systems that operate using these data. The scope of the ontology includes concepts regarding those aspects of investigation design and execution specific or unique to space environments, such as types of specialized equipment, operating organizations, and documentation. The ontology is continually being developed and published to the life science community (https://github.com/nasa/LSDAO/); at the time of this publication, the SLSO newly and uniquely defines 30 types (classes), 90 properties, and 14 relations specific to space life sciences metadata. In addition, the SLSO reuses (imports) some 2,360 types (classes), 49 properties, and 393 relations from other ontologies that are relevant to these kinds of metadata. In addition to its role as a common conceptualization for space biomedical research activities, the SLSO can also be used to provide automated support for traditionally difficult and expensive activities such as data curation and cross-system data integration and analysis.

fair↗

Cosmochemical Studies: Meteorites, Asteroidal Processes, Chondrules

Our research mainly concerned the asteroidal processes involved in the formation of meteorites and meteoritic chondrules. We continued to generate large amounts of instrumental-neutron-activation analysis (INAA) data, both for irons, chondrites and primitive achondrites. Major themes of our chondrule research were: (1) the temperature and crystallization history of individual chondrules, and (2) the evolution of the solar nebula during the period within which chondrule formation occurred. Much of our chondrule research was focused on the highly primitive CO3 chondrites. We initiated a study of the cooling history of high-FeO chondrules by characterizing the overgrowth layers on relict grains.. We also continued our studies of the composition and the formation of iron meteorites and the evolution of their parent planets. The large data sets that we have generated at UCLA allows systematic comparisons of the large magmatic groups both in terms of fractional crystallization (including rough estimates of non-metal contents of the parental melts) and in terms of the effects of variable contents of trapped melt. We have completed a preliminary study of group IIIAB in which we developed a trapped-melt model and more detailed studies of group IVA and the main-group pallasites. By comparing these large groups and modeling them by a combination of crystallization and melt trapping, we are able to better define both the formation processes and the nature of the solid/liquid elemental partitioning. We helped maintain the excellent neutron-activation facilities at UCLA, a major resource for the cosmochemical community.

Wasson, John T.↗

Clean Cities and Communities Partnership 2024 Activity Report

Clean Cities and Communities (CC&C) is a U.S. Department of Energy (DOE) partnership that fosters collaboration and innovation to advance transportation energy choices nationwide. More than 75 DOE-designated CC&C coalitions work in urban, suburban, and rural areas to deliver objective technical expertise based on a unique understanding of local markets. As partners with DOE's Transportation Technologies Office (TTO), coalitions build bridges between national priorities and local needs to create transportation energy systems that are affordable, reliable, and secure. Together, coalitions create compounding impacts nationwide that support locally driven energy choices and benefit regional economic development and job growth. This report summarizes the success and impact of partnership activities based on data and information provided in their annual reports.

2024↗

Reaction Kinetics of Water Molecules with Oxygen Vacancies on Rutile TiO 2 (110)

The formation of bridging hydroxyls (OHb) via reactions of water molecules with oxygen vacancies (VO) on reduced TiO 2 (110) surfaces is studied using infrared reflection-absorption spectroscopy (IRAS), electron-stimulated desorption (ESD), and photon-stimulated desorption (PSD). Narrow IRAS peaks at 2737 cm-1 and 3711 cm -1 are observed for stretching vibrations of OD b and OH b on TiO 2 (110), respectively. IRAS measurements with s- and p-polarized light demonstrate that the bridging hydroxyls are oriented normal to the (110) surface. The IR peaks disappear after the sample is exposed to O 2 or annealed in the temperature range of 400 – 600 K (correlating with the temperature at which pairs of OHb’s reform water and then desorb), which is consistent with their identification as bridging hydroxyls. We have studied the kinetics of water reacting with the vacancies by monitoring the formation of bridging hydroxyls (using IRAS) as a function of the annealing temperature for a small amount of water initially dosed on the TiO 2 (110) at low temperature. Separate experiments have also monitored the loss of water molecules (using water ESD) and vacancies (using the CO photooxidation reaction) due to the reactions of water molecules with the vacancies. All three techniques show that the reaction rate becomes appreciable for T > 150 K and that the reactions largely complete for T > 250 K. The temperature-dependent water-VO reaction kinetics are consistent with a Gaussian distribution of activation energies with E a = 0.545 eV, ΔE a (FWHM) = 0.125 eV, and a “normal” prefactor, v = 10 12 s -1 . In contrast, a single activation energy with a physically reasonable prefactor does not fit the data well. Our experimental activation energy is close to theoretical estimates for the diffusion of water molecules along the Ti 5c rows on the reduced TiO 2 (110) surface, which suggests that the diffusion of water controls the water – V O reaction rate.

74 ATOMIC AND MOLECULAR PHYSICS↗

Montana Water Resources II: Enhancing a Moisture Index for Drought and Flood Monitoring in the Missouri River Basin

The Missouri River Basin is a major global breadbasket, containing large amounts of agricultural land. Recent devastating weather events have motivated regional organizations to dedicate efforts to drought and flood monitoring and early warning systems. The DEVELOP team partnered with the following organizations: Montana Climate Office, NOAA National Weather Service (NWS) Missouri Basin River Forecast Center, NOAA Regional Climate Services of the Central Region, NOAA Physical Sciences Laboratory, and the US Army Corps of Engineers' Missouri River Basin Water Management Division. The team collaborated with the partners in their efforts to monitor flood and drought by enhancing a composite moisture index (CMI) for the Missouri River Basin. The CMI leverages NASA Earth observations to derive snow cover data from the Terra Moderate Resolution Imaging Spectroradiometer (MODIS) mission and snow water equivalent and snowdepth datasets from the NOAA NWS National Operational Hydrologic Remote Sensing Center’s Snow Data Assimilation System (SNODAS). Building upon this framework, the team added groundwater storage data from the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On missions, soil moisture data from Soil Moisture Active Passive (SMAP), and United States Geological Survey in situ streamflow data to the CMI. To test the tool’s validity, the team compared the CMI results to historically extreme dry and extreme wet years, March 2017 and March 2019, respectively. The CMI accurately reflects both 2017 and 2019 climate conditions in the Missouri River Basin. The refined CMI enhances the understanding of antecedent soil moisture conditions and improves flood and drought forecasting in the Missouri River Basin before the growing season.

Chloe Schneider↗

Toward the Development of an Integrated Global Observing Strategy

In the current environment of stagnant or shrinking budgets for space research and exploration, nations can no longer afford to develop costly systems in a vacuum. Greater coordination of existing and planned systems, both among space agencies and between the space agencies and user communities, will enable the maximization of global investments in all areas of space-related research. In this manner, a group of space agencies has embarked on an initiative to link their activities in Earth observation with complementary observation programs. The goal of this initiative is to develop a comprehensive strategy for enhanced levels of support to scientific, operational and research communities. The space agencies, through the Committee on Earth Observation Satellites (CEOS), have embraced the concept of an Integrated Global Observing Strategy (IGOS), primarily in fulfillment of their own set of objectives and to derive greater benefit from both operating and planned Earth observing systems. Through working together, CEOS agencies are in a position to plan their Earth observation projects with the minimum of unnecessary overlap and to devise joint strategies for addressing serious gaps in their observation capabilities. Ultimately, an IGOS should be the joint product of all groups involved in the collection and analysis of both space-based and in-situ data. CEOS is actively seeking IGOS -related partnerships with the Global Climate, Global Ocean and Global Terrestrial Observing Systems, their intergovernmental Sponsors, the International Group of Funding Agencies for Global Change Research, and other scientific and user organizations including the International Geosphere-Biosphere Programme and the World Climate Research Programme.

Charles, Leslie Bermann↗

Genesis Solar Wind – Capture, Return, Curate and Analyze: Looking Backward and Creating a Timeline

Introduction: In 1997 NASA’S Discovery Program selected the Genesis mission proposal to return solar wind samples to Earth for laboratory analyses. Principal Investigator Donald S. Burnett and the science team defined the purity of collector materials and ability to analyze solar wind composition to the precision required for planetary science. As a small mission, focused on a well-defined science goal, yet needing careful attention to engineering details, the communication among scientists and engineers, nurtured by Don Burnett, was exceptional. Genesis Mission and Curation Legacy: Genesis, as the first U. S. spacecraft to return astromaterial samples since Apollo, not only integrated the mission planning and flight teams, but also the science and sample curation teams during the mission development period. Since Genesis is a sample return mission, the Science Team was essential in certifying the collectors (sample containers for solar atoms). From inception, Genesis established mission funding for returned sample curation. JSC was lead in contamination control during mission preparation, including establishment of an ISO 4 cleanroom facility and use of ultrapure water (UPW) for cleaning flight hardware (and, as it turned out, for cleaning collectors after the mishap). Reliable, fast communication among scientists, engineers and curators at the hands-on level established deep respect among team members and efficient decision-making. JSC’s 50-years of astromaterial sample curation provided experienced sample processors onsite during recovery in Utah (a deep bench for emergency response). Post-recovery curation included iterative collaboration with science sample users to clean or verify cleanliness of samples. The science legacy from Genesis is addressed by Burnett and Jurewicz, this volume. In The Beginning: After Apollo sample return, Burnett and Marcia Neugebauer at JPL began discussing a solar wind sample return, with Neugebauer arguing that separate collection of solar wind regimes was essential science. By 1992 a solar wind sample return mission was presented at a workshop, and by 1994 a mission was proposed named Suess-Urey. The mission was re-proposed under a new name GENESIS and selected in 1997. Susan Niebur captured the Genesis mission history and stories, from high level management documents and from many interviews with participants [2]. Her account lets readers glimpse personality of participants in quotations from interviews. Need and Scope for Detailed Technical Timeline: A timeline constructed from lower level task documents has been initiated to document the resources and skills actually used, as well as task sequence or concurrency. Timelines for high level mission events are captured in two documents [1] [2] and for detailed re-entry events in [3]. A detailed technical timeline for Genesis mission and curation activities will provide data points for lower level tasks, such as ISO 4 curation facility construction time, preparation for nominal sample field recovery, mishap recovery, and UPW expansion. Changes in technology context 1990-2024: Semiconductor technologies were easily accessible in the U.S.A. (1990-1999), and the Genesis team used those resources for cleanroom design and UPW system expansion. Image documentation was changing from film to digital during cleanroom construction and payload cleaning (1997-2001). Engineering design was done using computer aided design proprietary software, making more difficult the archiving of payload configuration and materials. Email of documents, tracked delivery service and virtual meeting capability greatly improved communication efficiency. Information sources – Pre-launch mission preparation: Examples of mission science, engineering and contamination control are collector purity testing, payload design/fabrication and ISO 4 cleanroom construction. Information on timing of these activities comes from facility readiness reviews, management reviews, shipping documents, procurement documents, test reports, travel documents, laboratory logs, Quality Assurance documents, dates on images, participant notebooks and emails. Information sources – Sample return re-entry and field recovery activities: Information comes from event timelines produced by Mid-Air Recovery team, Lockheed team lead notes and from chase video, JPL Quality Assurance. Information also comes from images and logbooks from UTTR cleanroom operations and from curatorial documents. Information sources – Resulting science and sample cleaning processes: Agendas from the annual gatherings of the science team initially trace testing for collector purity/cleanliness, and after sample recovery, include collector cleaning and cleanliness assessment. Post-recovery documents include curatorial orders and procedures, sample allocation documents and LPSC abstracts. Timeline Objectives: A simple spreadsheet timeline with headers DATE, EVENT, PEOPLE, COMMENT, INFORMATION SOURCE has been initiated and currently has over 90 entries. While this is not definitive historical research, it is a quick look at the evolution of Genesis curation with pointers to documents or people with information. Engineers for future missions may find useful points of comparison for development of facilities. References:[1] Genesis Mission Reference Document, (2011) JPL D-62382.[2] Niebur S. M., edited by Brown D. W. (2023) NASA’s Discovery Program: The First 20 Years of Competitive Planetary Exploration, NASA-SP-2023-4238.[3] Genesis Mishap Investigation Board Report, Vol. 1 (July 2005).

solar wind↗

Effect of contrast on the active control of a moving line

In many passive visual tasks, human perceptual judgments are contrast dependent. To explore whether these contrast dependencies of visual perception also affect closed-loop manual control tasks, we examined visuomotor performance as humans actively controlled a moving luminance-defined line over a range of contrasts. Four subjects were asked to use a joystick to keep a horizontal line centered on a display as its vertical position was perturbed by a sum of sinusoids under two control regimes. The total root mean square (RMS) position error decreased quasi-linearly with increasing log contrast across the tested range (mean slope across subjects: -8.0 and -7.7% per log2 contrast, for the two control regimes, respectively). Frequency-response (Bode) plots showed a systematic increase in open-loop gain (mean slope: 1.44 and 1.30 dB per log2 contrast, respectively), and decrease in phase lag with increasing contrast, which can be accounted for by a decrease in response time delay (mean slope: 32 and 40 ms per log2 contrast, respectively). The performance data are well fit by a Crossover Model proposed by McRuer and Krendel, which allowed us to identify both visual position and motion cues driving performance. This analysis revealed that the position and motion cues used to support manual control under both control regimes appear equally sensitive to changes in stimulus contrast. In conclusion, our data show that active control of a moving visual stimulus is as dependent on contrast as passive perception and suggest that this effect is attributed to a shared contrast sensitivity early in the visual pathway, before any specialization for motion processing.

Contrast Sensitivity/physiology↗

Paraventricular Stimulation with Glutamate Elicits Bradycardia and Pituitary Responses

The excitatory neurotransmitter, L-glutamate (0.5 M, pH 7.4), or the organic acid, acetate (0.5 M, pH 7.4), was microinjected (50 nl over 2 min) directly into the paraventricular nuclei (PVN) of pentobarbital sodium-anesthetized rats while arterial blood pressure and heart rate and plasma adrenocorticotropic hormone (ACTH), vasopressin, and oxytocin were measured. Activation of PVN neurons with L-glutamate led to increases in plasma ACTH, vasopressin, and oxytocin and a profound bradycardia (-80 beats/min) with little change in arterial blood pressure. Microinjection of acetate had no effect on the above variables. The decrease in heart rate was shown to be dependent on the concentration of glutamate injected and the volume of injectate. The bradycardia was mediated through the autonomic nervous system because ganglionic blockade (pentolinium tartrate) eliminated the response; atropine and propranolol severely attenuated the bradycardia. The bradycardia was greatest when L-glutamate was microinjected into the caudal PVN. Injections into the rostral PVN or into nuclei surrounding the PVN led to small or nonsignificant decreases in heart rate. Focal electric stimulation (2-50 pA) of the PVN also led to decreases in heart rate and arterial blood pressure. These data suggest that activation of PVN neurons leads to the release of ACTH, vasopressin, and oxytocin from the pituitary and a bradycardia that is mediated by the autonomic nervous system.

Darlington, Daniel N.↗

Science Enabling Roles and Services of SPDF

The current Heliophysics Science Data Management Policy defines the roles of the Space Physics Data Facility (SPDF) project as a heliophysics active Final Archive, a focus for critical data infrastructure services and a center of excellence for data and ancillary information services. This presentation will highlight some of our current activities and our understanding of why and how our services are useful to researchers, as well as SPDF's programmatic emphasis in the coming year. We will discuss how. in cooperation with the Heliophysics Virtual discipline Observatories (VxOs), we are working closely with the RBSP and MMS mission teams to support their decisions to use CDF as a primary format for their public data products, to leverage the ongoing data flows and capabilities of CDAWeb (directly and through external clients such as Autoplot) to serve their data in a multi-mission context and to use SSCWeb to assist community science planning and analysis. Among other current activities, we will also discuss and demonstrate our continuing effort to make the Virtual Space Physics Observatory (VSPO) service comprehensive in all significant and NASA relevant heliophysics data. The OMNI and OMNI High Resolution datasets remain current and heavily cited in publications. We are expanding our FTP file services to include online archived non-CDF data from all active missions, which is a re-hosting of this function from NSSDC's FTP site. We have extended the definitions of time in CDF to unambiguously and consistently handle leap seconds. We are improving SSCWeb for much faster per1ormance, more capabilities and a web services inter1ace to Query functionality. We will also review how CDAWeb data can be easily accessed within IDL and new features in CDAWeb.

McGuire, Robert E.↗

Graph-Based Modeling for the Detection and Tracking of Sarin-Surrogate-Induced Neurotoxicity Using a Human-Relevant, In-Vitro Brain Model

Organophosphorus (OP) nerve agents are a chemical threat to the United States, to the civilian population (e.g., pesticides) and historically weaponized (e.g., sarin) as chemical warfare agents. The unprecedented, accelerated process from “bench-to-bedside” during the SARSCov2 pandemic has made it clear that technology and tools need to be readily available for immediate response. Advances in human organ tissue mimetic systems are a promising technology to evaluate the human-relevant response in vitro for basic and applied research and drug screening. In particular, current brain microphysiological systems (MPS) have the capability to monitor and detect changes in engineered human neural circuit activity. However, current data analytics approaches for these systems lack the granularity to functionally detect and distinguish the different mechanisms that occur in the brain following neurotoxicity, injury, and disease. The goal of this project was to advance the computational analytical capabilities of the brain MPS to detect functional changes in neural circuit structure at different stages of Sarin surrogate-induced neurotoxicity. We developed graph-based models to (1) identify the composition of the neural circuit structure; (2) detect and monitor how this structure changes following sarin-induced neurotoxicity; and (3) evaluate the analytical pipeline using known/promising oxime reactivators. Through experiments on the bMPS where in vitro neuronal cultures were exposed to a sarin surrogate, we demonstrated the capabilities of our computational pipeline to identify different responses in the functional networks of brain cells exposed to low and high concentrations of the nerve agent. We identified a biphasic response of human neural network activity following exposure to a sarin-surrogate that had not been reported in the literature before. The graph-based models and software developed in this project can be used for future studies that leverage the brain MPS technology, such as treatment efficacy assessment.

59 BASIC BIOLOGICAL SCIENCES↗