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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,513 records · Page 84
All sourcesNASA NTRSDOE OSTI
NASA NTRS2019

The Zwicky Transient Facility: Science Objectives

The Zwicky Transient Facility (ZTF), a public–private enterprise, is a new time-domain survey employing a dedicated camera on the Palomar 48-inch Schmidt telescope with a 47 sq. deg field of view and an 8 second readout time. It is well positioned in the development of time-domain astronomy, offering operations at 10% of the scale and style of the Large Synoptic Survey Telescope (LSST) with a single 1-m class survey telescope. The public surveys will cover the observable northern sky every three nights in g and r filters and the visible Galactic plane every night in g and r. Alerts generated by these surveys are sent in real time to brokers. A consortium of universities that provided funding (“partnership”) are undertaking several boutique surveys. The combination of these surveys producing one million alerts per night allows for exploration of transient and variable astrophysical phenomena brighter than r ~20.5 on timescales of minutes to years. We describe the primary science objectives driving ZTF, including the physics of supernovae and relativistic explosions, multi-messenger astrophysics, supernova cosmology, active galactic nuclei, and tidal disruption events, stellar variability, and solar system objects.

Matthew J. Graham↗
NASA NTRSDate not supplied

Thermally Conductive Melt-Processable Polyimide HBN Micro-Composites for High Temperature Electrical Insulation Applications

Thermoplastic polymers exhibit excellent dielectric properties and manufacturing robustness. These properties mark thermoplastics as competitive material candidates for electrical insulation applications. However, the high-temperature performance of most thermoplastics is insufficient to meet the electrical wiring requirements for next-generation air and space transportation engineering designs, with continuous operation temperature requirements of up to 200 °C among other design requirements. Furthermore, the low thermal conductivity (κ) of polymers as a material class leads to heat trapping within wires which can amplify thermal stresses. As a result, there is a need to investigate candidate thermoplastic systems for their high temperature, dielectric, and κ performance.

polyimide↗
NASA NTRS2024

Connecting the Low to High Corona: Propagating Disturbances as Tracers of the Near-Sun Solar Wind

We revisit a quiet 14 day period of solar minimum during 2008 January and track substreamer propagating disturbances (PDs) from low heights in STEREO/EUVI to the extended corona through STEREO/COR1 and into STEREO/COR2 along nonradial paths that trace the structure of the underlying streamers. Using our recently developed method for generating nonradial height–time profiles of outward PDs (OPDs) and inward PDs (IPDs), we obtained their velocities along the radial and position angle directions. Our analysis of 417 unique OPDs revealed two classes: slow and fast OPDs. Slow OPDs form preferentially at ≈1.6 Re closer to the streamer boundaries, with asymmetric occurrence rates, and show speeds of -+ - 16.4 km s 8.4 26.6 1 at 1.5 Re and accelerate up to- + - 200.1 km s 57.9 71.1 1 at 7.5 Re. Fast OPDs form preferentially at ≈1.6 Re and at ≈3.0 Re both at the streamer boundaries and slightly more often within them. They show speeds of - + - 87.8 km s 24.8 59.1 1 at 1.5 Re up to -+ - 197.8 km s 46.7 61.8 1 at 7.5 Re. IPDs are observed forming at ≈1.8 Re with speeds of tens of kilometers per second, mostly concentrated in the aftermath of a coronal mass ejection eruption. We present an example in which we show that periodic brightness variations related to OPDs remained in the range of 98 to 128 minutes, down to ≈2.0 Re, well within the field of view of COR1. The velocity profiles of slow OPDs for a heliocentric height below 3.0 Re show good agreement with speeds more closely related to the bulk solar wind obtained via interplanetary scintillation.

Astronomical techniques↗
DOE OSTI2019

Preliminary Evaluation of Removing Spent Nuclear Fuel from Shutdown Nuclear Power Plant Sites - 2018 - 19101

This is a technical paper that does not take into account the contractual limitations under the Standard Contract for Disposal of Spent Nuclear Fuel and/or High-Level Radioactive Waste (Standard Contract) (10 CFR Part 961). Under the provisions of the Standard Contract, DOE does not consider spent nuclear fuel in multi-assembly canisters to be an acceptable waste form, absent a mutually agreed to contract amendment. To the extent discussions or recommendations in this paper conflict with the provisions of the Standard Contract, the Standard Contract provisions prevail. The U.S. Department of Energy Office of Integrated Waste Management (DOE-IWM) continues to conduct evaluations of removing spent nuclear fuel (SNF) from shutdown nuclear power plant sites. The 14 shutdown sites included in the evaluation to date have nuclear power reactors that have been permanently shut down and the sites have been decommissioned or are undergoing decommissioning. The 14 shutdown sites are Maine Yankee, Yankee Rowe, Connecticut Yankee, Humboldt Bay, Big Rock Point, Rancho Seco, Trojan, La Crosse, Zion, Crystal River, Kewaunee, San Onofre, Vermont Yankee, and Fort Calhoun. The Oyster Creek Nuclear Generating Station ceased operations in September 2018 and will be included in future evaluations. The evaluations of the shutdown sites contain four components: - A characterization of the SNF and greater-than-Class C low-level radioactive waste (GTCC waste) inventory; - A description of the on-site infrastructure at the shutdown sites; - An evaluation of the near-site transportation infrastructure and experience at the shutdown sites - An evaluation of the actions necessary to prepare for and remove SNF and GTCC waste. The primary sources for the inventory of SNF were the DOE GC-859 and RW-859 spent nuclear fuel inventory databases. This inventory has been augmented with data obtained from the shutdown sites for SNF discharges that occurred after June 2013. The primary sources for information on the conditions of site and near-site transportation infrastructure and experience included field observations and information collected during visits to the 14 shutdown sites, information provided by managers and staff at the shutdown sites, and Google Earth imagery. Extensive photographs taken during the shutdown site visits have proven to be particularly useful in documenting the current conditions at and near the shutdown sites. Tribal and state representatives, State and Regional Group representatives, and Federal Railroad Administration representatives have participated in 11 of the shutdown site visits. In addition to visiting the shutdown site, site visits often include activities such as meeting with local railroads to discuss the near-site railroad infrastructure and meeting with community engagement panels. Oyster Creek permanently ceased power operations on September 17, 2018 and fuel was removed from the reactor vessel on September 25, 2018. Planning for the Oyster Creek site visit has begun and is conducted in three stages. In the first stage, data and documents that are applicable to Oyster Creek are collected. In the second stage, questions are developed based on the data and documents collected during the first stage. These questions are submitted to the Oyster Creek site approximately one month before the site visit. The third stage involves establishing specific schedules and participants. Participants will likely include tribal and state representatives, the Council of State Governments - Eastern Regional Conference, and the Federal Railroad Administration. State participation will likely include a representative of the State Rail Safety Participation Program, the New Jersey Department of Transportation, and the New Jersey Bureau of Nuclear Engineering. The site visit is tentatively expected to occur in April or May of 2019. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2019

Panel Session 76: US DOE Problematic Waste Streams and Policy Impacts

This panel provided an overview of DOE problematic waste streams including status and path forward. Potential policy implications that exist now and/or in the future were discussed. Topics included, greater-than-Class C low level waste, depleted uranium, and sodium waste. The panel also discussed potential treatment options for these wastes. As part of the introduction, Renee Echols welcomed the audience and went over a quick overview of what would be discussed on the panel. Theresa Kliczewski provided an overview of why this panel is relevant to US Department of Energy's Office of Environmental Management: there are problematic waste streams that still exist across the DOE cleanup complex. Theresa noted that the DOE EM Headquarters Office of Waste and Materials Management (EM-4.2), for which she is employed with, continues to work with the DOE cleanup sites on a path forward for these problematic waste streams. Presentations proposed include: 1 - Overview of Greater-Than-Class C Low-Level Radioactive Waste Disposal Path Forward (Theresa Kliczewski, US DOE EM (USA)); 2 - Status of Draft Supplemental Environmental Impact Statement for Disposition of Depleted Uranium Oxide Conversion Product Generated from DoE's Inventory of Depleted Uranium Hexafluoride (Jaffet Ferrer-Torres, US DOE (USA)); 3 - Problematic Waste Streams on the Oak Ridge Reservation (John Wrapp, UCOR (USA)); 4 - K Basin Sludge Removal (Ryan Covert, CH2M Hill PRC (USA)); 5 - Providing Technology Solutions for Treatment of Challenging Waste Streams (Tammy Monday, Perma-Fix Environmental Services (USA)); 6 - Treatment of Problematic Reactive Metal Waste Using the GeoMelt{sup R} In-Container Vitrification (ICV{sup TM}) Process (Ron Mitchell, Veolia Nuclear Solutions (USA))

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2023

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatases PTPN2 and PTPN1 are central regulators of inflammation, and their genetic deletion in either tumour cells or immune cells promotes anti-tumour immunity. However, phosphatases are challenging drug targets; in particular, the active site has been considered undruggable. Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 treatment in vitro amplifies the response to interferon and promotes the activation and function of several immune cell subsets. In mouse models of cancer resistant to PD-1 blockade, AC484 monotherapy generates potent anti-tumour immunity. We show that AC484 inflames the tumour microenvironment and promotes natural killer cell and CD8 + T cell function by enhancing JAK–STAT signalling and reducing T cell dysfunction. Inhibitors of PTPN2 and PTPN1 offer a promising new strategy for cancer immunotherapy and are currently being evaluated in patients with advanced solid tumours (ClinicalTrials.gov identifier NCT04777994). More broadly, our study shows that small-molecule inhibitors of key intracellular immune regulators can achieve efficacy comparable to or exceeding that of antibody-based immune checkpoint blockade in preclinical models. Finally, to our knowledge, AC484 represents the first active-site phosphatase inhibitor to enter clinical evaluation for cancer immunotherapy and may pave the way for additional therapeutics that target this important class of enzymes.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Reduced-order microstructure-sensitive protocols to rank-order the transition fatigue resistance of polycrystalline microstructures

We present that the transition fatigue regime between low cycle fatigue (LCF) and high cycle fatigue (HCF) is often addressed in the design and performance evaluation of load-bearing components used in many structural applications. Transition fatigue is characterized by elevated levels of local inelastic deformation in significant regions of the microstructure as compared to HCF. Typically, crystal plasticity finite element method (CPFEM) simulations are performed to model this phenomenon and to rank-order microstructures by their resistance to crack formation and early growth in the regime of transition fatigue. Unfortunately, these approaches require significant computational resources, inhibiting their use to explore novel materials for transition fatigue resistance. Reduced-order, microstructure-sensitive models are needed to accelerate the search for next-generation, fatigue-resistant materials. In a recent study, Paulson et al. (2018) extended the materials knowledge system (MKS) framework for rank-ordering the HCF resistance of polycrystalline microstructures. The efficacy of this approach lies in the reduced-dimensional representation of microstructures through 2-point spatial correlations and principal component analysis (PCA), in addition to the characterization of the HCF response with a small set of performance measures. In this work, these same protocols are critically evaluated for their applicability to rank-order the transition fatigue resistance of the same class of polycrystalline microstructures subjected to increased strain amplitudes. Success in this endeavor requires the formation of homogenization linkages that account for the significantly higher levels of local inelastic deformation and stress redistribution in transition fatigue as compared to HCF. Finally, a set of 12 α-titanium microstructures generated using the open access DREAM.3D software (Groeber and Jackson, 2014) are employed for this evaluation.

2-point correlations↗
DOE OSTI2026

Alchemy: A Model-Based Approach for 2D to 3D Autonomous Nuclear System Design

Engineering design of nuclear power plant (NPP) piping and equipment systems frequently bypasses crucial 2D system planning, instead moving straight to 3D modeling. This often leads to designs that exceed building envelope constraints, forcing expensive and time-consuming redesigns. When 2D modeling is employed, it typically involves labor-intensive manual workflows that convert 2D drawings into 3D models, resulting in inefficiencies and errors across design iterations. These workflows further suffer from poor software interoperability and dependence on proprietary software ecosystems, thereby contributing to schedule delays and cost overruns. This paper presents Alchemy, an autonomous framework that transforms 2D system definitions into Industry Foundation Classes (IFC)-compliant 3D building information models (BIMs) for expediting nuclear facility design at the conceptual preliminary phase. Using a model-based approach, the framework treats the 2D system diagram as the central reference model employed to automatically generate all subsequent outputs, ensuring consistency between the system definition and the resulting physical design. A web-based interface enables engineers to define hierarchical system topologies including associated equipment, geometric properties, and connectivity requirements. A two-phase equipment layout optimization algorithm automatically computes collision-free spatial configurations within predefined building envelopes. An artificial intelligence (AI)-assisted pipe routing module then generates orthogonal, collision-free routing paths, allowing the user to select either an A* search-based method or an Ant Colony Optimization (ACO)-based method. All outputs are authored natively in IFC format, relying on open-source technologies and standardized formats in order to ensure extensibility and eliminate proprietary software dependencies. The proposed framework is validated on two representative pressurized-water reactor (PWR)-based case studies, for which it autonomously generates IFC-compliant 3D models in minutes, drastically reducing workflows that typically require hours of manual effort. The generated model demonstrates topologically correct equipment placement, physically plausible spatial relationships, and collision-free pipe routing consistent with known PWR loop configurations. This work represents a foundational step toward digital engineering for nuclear facility preliminary design, with future ongoing development targeting design code compliance and expanded system complexity.

97 - MATHEMATICS AND COMPUTING↗
DOE OSTI2013

Discovery of a new motion mechanism of biomotors similar to the earth revolving around the sun without rotation

Biomotors have been classified into linear and rotational motors. For 35 years, it has been popularly believed that viral dsDNA-packaging apparatuses are pentameric rotation motors. Recently, a third class of hexameric motor has been found in bacteriophage phi29 that utilizes a mechanism of revolution without rotation, friction, coiling, or torque. This review addresses how packaging motors control dsDNA one-way traffic; how four electropositive layers in the channel interact with the electronegative phosphate backbone to generate four steps in translocating one dsDNA helix; how motors resolve the mismatch between 10.5 bases and 12 connector subunits per cycle of revolution; and how ATP regulates sequential action of motor ATPase. Since motors with all number of subunits can utilize the revolution mechanism, this finding helps resolve puzzles and debates concerning the oligomeric nature of packaging motors in many phage systems. This revolution mechanism helps to solve the undesirable dsDNA supercoiling issue involved in rotation. - Highlights: • New motion mechanism of revolution without rotation found for phi29 DNA packaging. • Revolution motor finding expands classical linear and rotation biomotor classes. • Revolution motors transport dsDNA unidirectionally without supercoiling. • New mechanism solves many puzzles, mysteries, and debates in biomotor studies. • Motors with all numbers of subunits can utilize the revolution mechanism.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

Enzyme-Directed Functionalization of Designed, Two-Dimensional Protein Lattices

The design and construction of crystalline protein arrays to selectively assemble ordered nanoscale materials has potential applications in sensing, catalysis and medicine. Whereas numerous designs have been implemented for the bottom-up construction of novel protein assemblies, the generation of artificial functional materials has been relatively unexplored. Enzyme-directed post-translational modifications are responsible for the functional diversity of the proteome and thus, could be harnessed to selectively modify artificial protein assemblies. In this study, we describe the use of phosphopantetheinyl transferases (PPTases), a class of enzymes that covalently modify proteins using coenzyme A (CoA), to site-selectively tailor the surface of designed, two-dimensional (2D) protein crystals. We demonstrate that a short peptide (ybbR) or a molecular tag (CoA) can be covalently tethered to 2D arrays to enable enzymatic functionalization using Sfp PPTase. Here, the site-specific modification of two different protein array platforms is facilitated by PPTases to afford both small-molecule- and protein-functionalized surfaces with no loss in crystalline order. This work highlights the potential for chemoenzymatic modification of large protein surfaces towards the generation of sophisticated protein platforms reminiscent of the complex landscape of cell surfaces.

36 MATERIALS SCIENCE↗
NASA NTRS2002

Environment-Conscious Ceramics (Ecoceramics) Technology Received 2001 R&D 100 Award

Since the dawn of human civilization, there has been a delicate balance between the use of resources as human frontiers expanded and the need to have a minimum influence on the ecosystem. The first 200 years of the industrial revolution essentially solved the problem of production. However, the massive production of goods also generated tremendous amounts of byproducts and wastes. In the new millennium, to sustain a healthy life in harmony with nature, it will be extremely important for us to develop various materials, products, and processes that minimize any harmful influence on the environment. Environment-conscious ceramics (ecoceramics) are a new class of materials that can be fabricated with renewable resources (wood) and wood waste material (wood sawdust). Wood is a "lignocellulosic" material formed by the photosynthetic reaction within the needles or leaves of trees. The photosynthesis process uses sunlight to take carbon dioxide from air and convert it into oxygen and organic materials. Wood has been known to be one of the best and most intricate engineering materials created by nature and known to mankind. In addition, natural woods of various types are available throughout the world. On the other hand, wood sawdusts are generated in abundant quantities by sawmills. Environment-conscious ceramic materials, fabricated via the pyrolysis and infiltration of natural wood-derived preforms, have tailorable properties with numerous potential applications. The experimental studies conducted to date on the development of materials based on biologically derived structures indicate that these materials behave like ceramic materials manufactured by conventional approaches. These structures have been shown to be quite useful in producing porous or dense materials having various microstructures and compositions.

Singh, Mrityunjay↗
DOE OSTI2015

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors

The search for new molecular constructs that resemble the critical two-metal binding pharmacophore required for HIV integrase strand transfer inhibition represents a vibrant area of research within drug discovery. Here we present the discovery of a new class of HIV integrase strand transfer inhibitors based on the 2-pyridinone core of MK-0536. These efforts led to the identification of two lead compounds with excellent antiviral activity and preclinical pharmacokinetic profiles to support a once-daily human dose prediction. Dose escalating PK studies in dog revealed significant issues with limited oral absorption and required an innovative prodrug strategy to enhance the high-dose plasma exposures of the parent molecules.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2018

Generators for Spaces of Entire Functions with a System of Weighted Estimates

We consider spaces of entire functions with systems of weighted estimates. The case of twoterm weight sequences consisting of radial and nonradial components is studied. Under some assumptions on the weight sequence, we obtain a complete description of generators in these spaces. We apply this result to the problem of normal solvability of systems of convolution equations in the Roumieu spaces of ultradifferentiable functions and, as a particular case, in Gevrey classes.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2021

Impact of graph structures for QAOA on MaxCut

The quantum approximate optimization algorithm (QAOA) is a promising method of solving combinatorial optimization problems using quantum computing. QAOA on the MaxCut problem has been studied extensively on graphs with specific structure; however, little is known about the general performance of the algorithm on arbitrary graphs. Here, we investigate how different graph characteristics correlate with QAOA performance at depths at most three on the MaxCut problem for all connected non-isomorphic graphs with at most eight vertices. Some good predictors of QAOA success relate to graph symmetries, odd cycles, and density. For example, on eight vertex graphs, the average probability for selecting an optimal solution for graphs that contain no odd cycles after three iterations of QAOA is 60.6% compared to 48.2% for those that do. The data generated from these studies are shared in a publicly accessible database to serve as a benchmark for QAOA calculations and experiments. Knowing the relationship between structure and performance can be used to identify classes of combinatorial problems that are likely to exhibit a quantum advantage.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2019

Magnetoelectric behavior via a spin state transition

Abstract In magnetoelectric materials, magnetic and dielectric/ferroelectric properties couple to each other. This coupling could enable lower power consumption and new functionalities in devices such as sensors, memories and transducers, since voltages instead of electric currents are sensing and controlling the magnetic state. We explore a different approach to magnetoelectric coupling in which we use the magnetic spin state instead of the more traditional ferro or antiferromagnetic order to couple to electric properties. In our molecular compound, magnetic field induces a spin crossover from the S = 1 to the S = 2 state of Mn 3+ , which in turn generates molecular distortions and electric dipoles. These dipoles couple to the magnetic easy axis, and form different polar, antipolar and paraelectric phases vs magnetic field and temperature. Spin crossover compounds are a large class of materials where the spin state can modify the structure, and here we demonstrate that this is a route to magnetoelectric coupling.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Insights into the unique carboxylation reactions in the metabolism of propylene and acetone

Alkenes and ketones are two classes of ubiquitous, toxic organic compounds in natural environments produced in several biological and anthropogenic processes. In spite of their toxicity, these compounds are utilized as primary carbon and energy sources or are generated as intermediate metabolites in the metabolism of other compounds by many diverse bacteria. The aerobic metabolism of some of the smallest and most volatile of these compounds (propylene, acetone, isopropanol) involves novel carboxylation reactions resulting in a common product acetoacetate. Propylene is metabolized in a four-step pathway involving five enzymes where the penultimate step is a carboxylation reaction catalyzed by a unique disulfide oxidoreductase that couples reductive cleavage of a thioether linkage with carboxylation to produce acetoacetate. The carboxylation of isopropanol begins with conversion to acetone via an alcohol dehydrogenase. Acetone is converted to acetoacetate in a single step by an acetone carboxylase which couples the hydrolysis of MgATP to the activation of both acetone and bicarbonate, generating highly reactive intermediates that are condensed into acetoacetate at a Mn2+ containing the active site. Acetoacetate is then utilized in central metabolism where it is readily converted to acetyl-coenzyme A and subsequently converted into biomass or utilized in energy metabolism via the tricarboxylic acid cycle. This review summarizes recent structural and biochemical findings that have contributed significant insights into the mechanism of these two unique carboxylating enzymes.

Biochemistry & Molecular Biology↗
DOE OSTI2015

Elegant Gaussian beams for enhanced optical manipulation

Generation of micro- and nanostructured complex light beams attains increasing impact in photonics and laser applications. In this contribution, we demonstrate the implementation and experimental realization of the relatively unknown, but highly versatile class of complex-valued Elegant Hermite- and Laguerre-Gaussian beams. These beams create higher trapping forces compared to standard Gaussian light fields due to their propagation changing properties. We demonstrate optical trapping and alignment of complex functional particles as nanocontainers with standard and Elegant Gaussian light beams. Elegant Gaussian beams will inspire manifold applications in optical manipulation, direct laser writing, or microscopy, where the design of the point-spread function is relevant.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2022

Kinetically driven ekpyrosis

We explore the possibility of a scalar field driving ekpyrotic contraction through a noncanonical kinetic energy density rather than a negative potential. We find that this kinetically driven ekpyrosis (“k-ekpyrosis”) can be achieved in a variety of models, including scalar field theories with power-law, polynomial, or Dirac-Born-Infeld (DBI-)like kinetic terms in the action. Of these examples, the ekpyrotic phase is best sustained in power-law models, which can generate large and constant equation-of-state parameters, followed by DBI-like models, which can exhibit dynamical attractors toward similarly large equations of state. Here we show that for a broad class of theories including these examples, phases of k-ekpyrosis are accompanied by preceding or concurrent phases of superluminality.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗