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At least 163 records · Page 9

Space Radiation Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts: Persistence of Damage After Flight and the Effects of Repeat Long Duration Missions

Cytogenetic damage was assessed in blood lymphocytes from astronauts before and after they participated in long-duration space missions of three months or more. The frequency of chromosome damage was measured by fluorescence in situ hybridization (FISH) chromosome painting before flight and at various intervals from a few days to many months after return from the mission. For all individuals, the frequency of chromosome exchanges measured within a month of return from space was higher than their prefight yield. However, some individuals showed a temporal decline in chromosome damage with time after flight. Statistical analysis using combined data for all astronauts indicated a significant overall decreasing trend in total chromosome exchanges with time after flight, although this trend was not seen for all astronauts and the yield of chromosome damage in some individuals actually increased with time after flight. The decreasing trend in total exchanges was slightly more significant when statistical analysis was restricted to data collected more than 220 days after return from flight. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from three crewmembers who has participated in two separate long-duration space missions provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.

George, Kerry↗

Evolvable Mars Campaign Long Duration Habitation Strategies: Architectural Approaches to Enable Human Exploration Missions

The Evolvable Mars Campaign (EMC) is the current NASA Mars mission planning effort which seeks to establish sustainable, realistic strategies to enable crewed Mars missions in the mid-2030s timeframe. The primary outcome of the Evolvable Mars Campaign is not to produce "The Plan" for sending humans to Mars, but instead its intent is to inform the Human Exploration and Operations Mission Directorate near-term key decisions and investment priorities to prepare for those types of missions. The FY'15 EMC effort focused upon analysis of integrated mission architectures to identify technically appealing transportation strategies, logistics build-up strategies, and vehicle designs for reaching and exploring Mars moons and Mars surface. As part of the development of this campaign, long duration habitats are required which are capable of supporting crew with limited resupply and crew abort during the Mars transit, Mars moons, and Mars surface segments of EMC missions. In particular, the EMC design team sought to design a single, affordable habitation system whose manufactured units could be outfitted uniquely for each of these missions and reused for multiple crewed missions. This habitat system must provide all of the functionality to safely support 4 crew for long durations while meeting mass and volume constraints for each of the mission segments set by the chosen transportation architecture and propulsion technologies. This paper describes several proposed long-duration habitation strategies to enable the Evolvable Mars Campaign through improvements in mass, cost, and reusability, and presents results of analysis to compare the options and identify promising solutions. The concepts investigated include several monolithic concepts: monolithic clean sheet designs, and concepts which leverage the co-manifested payload capability of NASA's Space Launch System (SLS) to deliver habitable elements within the Universal Payload Adaptor between the SLS upper stage and the Orion/Service module on the top of the vehicle. Multiple modular habitat options for Mars surface and in-space missions are also considered with various functionality and volume splits between modules to find the best balance of reducing the single largest mass which must be delivered to a destination and reducing the number of separate elements which must be launched. Analysis results presented for each of these concepts in this paper include mass/volume/power sizing using parametric sizing tools, identification of unique operational constraints, and limited comments on the additional impacts of reusability/dormancy on system design. Finally, recommendations will be made for promising solutions which will be carried forward for consideration in the Evolvable Mars Campaign work.

Simon, Matthew A.↗

A Dedicated, Long Duration Balloon Mission from Antarctica to Measure the Effects of Low Dose Galactic Cosmic Radiation on Biology

Antarctic long duration balloon missions flown by NASA’s Science Mission Directorate (SMD)can be used as a surrogate for the deep space radiation environment, reducing the need to launch orbital experiments to assess the impact of galactic cosmic radiation (GCR) on biology. To date, over fifty NASA balloon missions flown from Antarctica have carried scientific payloads from Astrophysics (APD) and Heliophysics (HPD)in SMD. Only two life science experiments have been flown from Antarctica, and both were ride-along (piggyback) opportunities, limiting the sophistication and types of model organisms that can be incorporated into studies. Herein, we argue for establishing a large, dedicated Antarctic balloon mission for the Biological and Physical Sciences (BPS) Division in SMD to be launched in 2029/2030, with an “omnibus” gondola carrying dozens of independent Space Biology payloads that would receive a sustained exposure to low dose rate GCRs for 30+ days. Our unprecedented, protracted radiation experiment cannot be done using ground-based simulation facilities or in space; it can only be achieved through an Antarctic balloon mission dedicated to BPS Division payloads. By providing more access to radiation research platforms through existing NASA SMD access to Antarctic balloon flight opportunities, the Space Biology community will be better positioned to address unknowns associated with low dose rate GCR exposures in long duration spaceflight.

David J Smith↗

Evaluation of Long Duration Flight on Venus

An analysis was performed to evaluate the potential of utilizing either an airship or aircraft as a flight platform for long duration flight within the atmosphere of Venus. In order to achieve long-duration flight, the power system for the vehicle had to be capable of operating for extended periods of time. To accomplish these, two types of power systems were considered, a solar energy-based power system utilizing a photovoltaic array as the main power source and a radioisotope heat source power system utilizing a Stirling engine as the heat conversion device. Both types of vehicles and power systems were analyzed to determine their flight altitude range. This analysis was performed for a station-keeping mission where the vehicle had to maintain a flight over a location on the ground. This requires the vehicle to be capable of flying faster than the wind speed at a particular altitude. An analysis was also performed to evaluate the altitude range and maximum duration for a vehicle that was not required to maintain station over a specified location. The results of the analysis show that each type of flight vehicle and power system was capable of flight within certain portions of Venus s atmosphere. The aircraft, both solar and radioisotope power proved to be the most versatile and provided the greatest range of coverage both for station-keeping and non-station-keeping missions.

Landis, Geoffrey A.↗

Comparison of Postural Recovery Following Short and Long Duration Spaceflights

INTRODUCTION: Post-flight postural ataxia reflects adaptive changes to vestibulo-spinal reflexes and control strategies adopted for movement in weightlessness. Quantitative measures obtained during computerized dynamic posturography (CDP) from US and Russian programs provide insight into the effect of spaceflight duration in terms of both the initial decrements and recovery of postural stability. METHODS: CDP was obtained on 117 crewmembers following Shuttle flights lasting 4-17 days, and on 64 crewmembers following long-duration missions lasting 48-380 days. Although the number and timing of sessions varied, the goal was to characterize postural recovery pooling similar measures from different research and flight medicine programs. This report focuses on eyes closed, head erect conditions with either a fixed or sway-referenced base of support. A smaller subset of subjects repeated the sway-referenced condition while making pitch head movements (+/- 20deg at 0.33Hz). Equilibrium scores were derived from peak-to-peak anterior-posterior sway. Fall probability was modeled using Bayesian statistical methods to estimate parameters of a logit function. RESULTS: The standard Romberg condition was the least sensitive. Longer duration flights led to larger decrements in stability with sway-reference support during the first 1-2 days, although the timecourse of recovery was similar across flight duration with head erect. Head movements led to increased incidence of falls during the first week, with a significantly longer recovery following long duration flights. CONCLUSIONS: The diagnostic assessment of postural instability, and differences in the timecourse of postural recovery between short and long flight durations, are more pronounced during unstable support conditions requiring active head movements.

Wood, S. J.↗

Habitability and Performance Issues for Long Duration Space Flights

Advancing technology, coupled with the desire to explore space has resulted in increasingly longer manned space missions. Although the Long Duration Space Flights (LDSF) have provided a considerable amount of scientific research on human ability to function in extreme environments, findings indicate long duration missions take a toll on the individual, both physiologically and psychologically. These physiological and psychological issues manifest themselves in performance decrements; and could lead to serious errors endangering the mission, spacecraft and crew. The purpose of this paper is to document existing knowledge of the effects of LDSF on performance, habitability, and workload and to identify and assess potential tools designed to address these decrements as well as propose an implementation plan to address the habitability, performance and workload issues.

Whitmore, Mihriban↗

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capability and Risk for Cardiac Arrhythmias

Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance, Exercise Capability and Risk for Cardiac Arrhythmias (Integrated Cardiovascular) will quantify the extent of long-duration space flightassociated cardiac atrophy (deterioration) on the International Space Station crewmembers.

Levine, Benjamin D.↗

Human Exploration Beyond LEO by the End of the Decade: Designs for Long-Duration "Gateway" Habitats

For the past few years, designs have been developed that are intended to demonstrate that a long-duration habitation system beyond LEO is plausible within several years. Here we summarize a pair of designs with the overriding goal of development and operation beyond LEO before the end of the decade that also build upon experiments and lessons learned from ISS. Both concepts here have the goal of an expandable long-duration habitat at Earth- Moon L1 and/or L2. Both options require subsequent launches for the astronauts. If a heavy-lift launch vehicle is available this decade, an expandable 30.5 mt habitat and departure-stage propulsion system may be launched to E-M L1,2 in a single launch and will offer 575 cubic meter (roughly half the habitable volume of ISS) If existing (or near-future) EELVs are the available launch vehicles this decade, a 16 mt, 170 cubic meter design that uses a pair of launches of Delta IV H and LEO rendezvous/fuel transfer to reach E-M L1,2.

Thronson, Harley↗

Electronic Repair Concepts for Long-Duration Spaceflight

Constraints on the mass and volume that can be allocated for electronics spares and repair equipment on long-duration space missions mean that NASA must look at repair strategies beyond the traditional approach, which has been to replace faulty subsystems in a modular form, termed Orbital Replacement Units or Line Replacement Units. Other possible strategies include component and board-level replacement, modular designs that allow reprogramming of less-critical systems to take the place of more critical failed systems, and a blended approach which uses elements of each of these approaches, along with a limited number of Line Replacement Units. This paper presents some of the constraints and considerations that affect the decision on how to approach electronics repair for long duration space missions, and discusses the benefits and limitations of each of the previously mentioned strategies.

Easton, John↗

GRB070125: The First Long-Duration Gamma-Ray Burst in a Halo Environment

We present the discovery and high signal-to-noise spectroscopic observations of the optical afterglow of the long-duration gamma-ray burst GRB070125. Unlike all previously observed long-duration afterglows in the redshift range 0.5 < z < 2.0, we find no strong (rest-frame equivalent width W > 1.0 A) absorption features in the wavelength range 4000 - 10000 A. The sole significant feature is a weak doublet we identify as Mg 11 2796 (W = 0.18 +/- 0.02 A), 2803 (W = 0.08 +0I.-01 ) at z = 1.5477 +/- 0.0001. The low observed Mg II and inferred H I column densities are typically observed in galactic halos, far away from the bulk of massive star formation. Deep ground-based imaging reveals no host directly underneath the afterglow to a limit of R > 25.4 mag. Either of the two nearest blue galaxies could host GRB070125; the large offset (d >= 27 kpc) would naturally explain the low column density. To remain consistent with the large local (i.e. parsec scale) circum-burst density inferred from broadband afterglow observations, we speculate GRB070125 may have occurred far away from the disk of its host in a compact star-forming cluster. Such distant stellar clusters, typically formed by dynamical galaxy interactions, have been observed in the nearby universe, and should be more prevalent at z>l where galaxy mergers occur more frequently.

Bradley, Cenko S.↗

Protein kinetics during and after long-duration spaceflight on MIR

Human spaceflight is associated with a loss of body protein. Bed rest studies suggest that the reduction in the whole body protein synthesis (PS) rate should be approximately 15%. The objectives of this experiment were to test two hypotheses on astronauts and cosmonauts during long-duration (>3 mo) flights on MIR: that 1) the whole body PS rate will be reduced and 2) dietary intake and the PS rate should be increased postflight because protein accretion is occurring. The 15N glycine method was used for measuring whole body PS rate before, during, and after long-duration spaceflight on the Russian space station MIR. Dietary intake was measured together with the protein kinetics. Results show that subjects lost weight during flight (4.64 +/- 1.0 kg, P < 0.05). Energy intake was decreased inflight (2,854 +/- 268 vs. 2,145 +/- 190 kcal/day, n = 6, P < 0.05), as was the PS rate (226 +/- 24 vs. 97 +/- 11 g protein/day, n = 6, P < 0.01). The reduction in PS correlated with the reduction in energy intake (r2 = 0.86, P < 0.01, n = 6). Postflight energy intake and PS returned to, but were not increased over, the preflight levels. We conclude that the reduction in PS found was greater than predicted from ground-based bed rest experiments because of the shortfall in dietary intake. The expected postflight anabolic state with increases in dietary intake and PS did not occur during the first 2 wk after landing.

STS-40 Shuttle Project↗

Effects of Long-Duration Microgravity on Fine Motor Skills: ISS One-Year Mission

Fine motor skills will be critical in future long-duration missions, particularly those skills needed to interact with advanced technologies in next-generation vehicles, spacesuits, and habitats. Studies to date on the effects of microgravity and gravitational transitions on fine motor performance have not yielded conclusive results. Datasets are incomplete-timeline gaps in the microgravity data sessions. Studies have not focused on the fine motor actions that are likely to be required for interacting with software displays and controls (pointing, clicking, dragging, multi-touch/pinching). The majority of studies have used a joystick or arm reaching task. Touchscreen tablets are already in use on ISS, and at least one commercial partner is already planning a cockpit with touchscreens as the primary means of input. We must ensure that crewmembers are ready to perform with computer-based devices after a long-duration voyage and transition to surface operations.

Kritina Holden↗

Long Duration Exposure Facility (LDEF) space environments overview

The Long Duration Exposure Facility (LDEF) was retrieved from Earth orbit in January 1990 after spending almost six years in space. It had flown in a near-circular orbit with an inclination of 28.5 degrees. Initially, the orbit altitude was approximately 257 nautical miles; however, when the LDEF was retrieved the orbit altitude had decayed to approximately 179 nautical miles. The LDEF was passively stabilized about three axes while in free flight, making it an ideal platform for exposing experiments which were measuring the environments of near-Earth space and investigating the long-term effects of these environments on spacecraft. A brief overview of the encountered environments that were of most interest to the LDEF investigators is presented.

Kinard, William H.↗

NASA's Rodent Research Project: Validation of Capabilities for Conducting Long Duration Experiments in Space

Research using rodents is an essential tool for advancing biomedical research on Earth and in space. Prior rodent experiments on the Shuttle were limited by the short flight duration. The International Space Station (ISS) provides a new platform for conducting rodent experiments under long duration conditions. Rodent Research (RR)-1 was conducted to validate flight hardware, operations, and science capabilities that were developed at the NASA Ames Research Center. Twenty C57BL6J adult female mice were launched on Sept 21, 2014 in a Dragon Capsule (SpaceX-4), then transferred to the ISS for a total time of 21-22 days (10 commercial mice) or 37 days (10 validation mice). Tissues collected on-orbit were either rapidly frozen or preserved in RNAlater at -80C (n2group) until their return to Earth. Remaining carcasses on-orbit were rapidly frozen for dissection post-flight. The three controls groups at Kennedy Space Center consisted of: Basal mice euthanized at the time of launch, Vivarium controls housed in standard cages, and Ground Controls (GC) housed in flight hardware within an environmental chamber. Upon return to Earth, there were no differences in body weights between Flight (FLT) and GC at the end of the 37 days in space. Liver enzyme activity levels of FLT mice and all control mice were similar in magnitude to those of the samples that were processed under optimal conditions in the laboratory. Liver samples dissected on-orbit yielded high quality RNA (RIN8.99+-0.59, n7). Liver samples dissected post-flight from the intact, frozen FLT carcasses yielded RIN of 7.27 +- 0.52 (n6). Additionally, wet weights of various tissues were measured. Adrenal glands and spleen showed no significant differences in FLT compared to GC although thymus and livers weights were significantly greater in FLT compared to GC. Over 3,000 tissue aliquots collected post-flight from the four groups of mice were deposited into the Ames Life Science Data Archives for future Biospecimen Sharing Program. Together, the RR validation flight successfully demonstrates the capability to support long-duration experimentation on the ISS to achieve both basic science and biomedical objectives.

spaceflight↗

Joint US-USSR Long duration Antarctic Mars calibration Balloon (LAMB) mission

The Long duration Antarctic Mars calibration Balloon (LAMB) project has been established at Goddard Space Flight Center for the evaluation and cross calibration of U.S. and USSR remote sensing gamma-ray and neutron detectors. These detectors are analogs of those flown on the Soviet Phobos mission around Mars and those to be flown on the upcoming U.S. Mars Observer mission. Cosmic rays, which are normally filtered out by the atmosphere, and the earth's magnetic field, will induce gamma-ray and neutron emissions from about a half ton of simulated Mars soil aboard the gondola. The cross calibration of these instruments should greatly facilitate the data analysis from both missions and play a role in U.S.-USSR cooperation in space.

Floyd, S. R.↗