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T wave alternans as a predictor of recurrent ventricular tachyarrhythmias in ICD recipients: prospective comparison with conventional risk markers
INTRODUCTION: The current standard for arrhythmic risk stratification is electrophysiologic (EP) testing, which, due to its invasive nature, is limited to patients already known to be at high risk. A number of noninvasive tests, such as determination of left ventricular ejection fraction (LVEF) or heart rate variability, have been evaluated as additional risk stratifiers. Microvolt T wave alternans (TWA) is a promising new risk marker. Prospective evaluation of noninvasive risk markers in low- or moderate-risk populations requires studies involving very large numbers of patients, and in such studies, documentation of the occurrence of ventricular tachyarrhythmias is difficult. In the present study, we identified a high-risk population, recipients of an implantable cardioverter defibrillator (ICD), and prospectively compared microvolt TWA with invasive EP testing and other risk markers with respect to their ability to predict recurrence of ventricular tachyarrhythmias as documented by ICD electrograms. METHODS AND RESULTS: Ninety-five patients with a history of ventricular tachyarrhythmias undergoing implantation of an ICD underwent EP testing, assessment of TWA, as well as determination of LVEF, baroreflex sensitivity, signal-averaged ECG, analysis of 24-hour Holter monitoring, and QT dispersion from the 12-lead surface ECG. The endpoint of the study was first appropriate ICD therapy for electrogram-documented ventricular fibrillation or tachycardia during follow-up. Kaplan-Meier survival analysis revealed that TWA (P < 0.006) and LVEF (P < 0.04) were the only significant univariate risk stratifiers. EP testing was not statistically significant (P < 0.2). Multivariate Cox regression analysis revealed that TWA was the only statistically significant independent risk factor. CONCLUSIONS: Measurement of microvolt TWA compared favorably with both invasive EP testing and other currently used noninvasive risk assessment methods in predicting recurrence of ventricular tachyarrhythmias in ICD recipients. This study suggests that TWA might also be a powerful tool for risk stratification in low- or moderate-risk patients, and needs to be prospectively evaluated in such populations.
Atmospheric, Magnetospheric and Plasmas in Space (AMPS) spacelab payload definition study. Volume 3: Interface control documents. Part 2: AMPS payload to spacelab ICD
The AMPS to Spacelab Interface Control Document which is to be used as a guide for format and information content in generating specific AMPS Mission ICDs is presented. This document is meant to supplement the Spacelab Payload Accommodations Handbook in that it only defines interfaces which are not discussed in the handbook to the level required for design purposes. The AMPS Top Level Requirements Tree, illustrates this ICD by a shaded area and its relationship to the other AMPS technical documents. Other interface documents shown are the Level II, AMPS to Space Shuttle Vehicle ICD and the Level III, AMPS to Instruments ICD.
Live Virtual Constructive (LVC): Interface Control Document (ICD) for the LVC Gateway
This Interface Control Document (ICD) documents and tracks the necessary information required for the Live Virtual and Constructive (LVC) systems components as well as protocols for communicating with them in order to achieve all research objectives captured by the experiment requirements. The purpose of this ICD is to clearly communicate all inputs and outputs from the subsystem components.
Apollo Intercenter ICD Management Procedure - Apollo Program
Apollo program intercenter ICD management procedure
External Wireless Communications (EWC) Coverage Expansion Boom Interface Control Document (ICD)
This document defines and controls the physical and functional interfaces between the External Wireless Communications Coverage Expansion (EWCCE) boom and any payload that is planned to be installed on the scarred locations on the boom. The hardware will be referenced as EWCCE boom or simply boom in this document. The boom is comprised of two short boom sections,the upper boom and the lower boom, an Active Worksite Interface (AWIF) and two mounting plates. The boom will be launched soft stowed in a bag and assembled in the Internation Space Station (ISS) via IVA. The assembly will include two sections of the boom and a built-to-print AWIF. The installation of the final assembly to the ISS Truss location is designated as a free-float EVA worksite activity. Once installed on the truss, the interfaces on the Long Boom may be used for attachment of future Orbital Replacement Units (ORUs) to either the Television Camera (TVC) Mounting Slide interface (e.g., an External High Definition Camera [EHDC] or similar ORU) or to future On-orbit Installed Hand-rails (OIHs) installed at the seat track interfaces. Compliance with this Interface Control Document (ICD) will ensure compatibility and successful integration of the hardware.
Atmospheric, Magnetospheric and Plasmas in Space (AMPS) spacelab payload definition study. Volume 3: Interface control documents. Part 1: AMPS payload to shuttle ICD
Physical, functional, and operational interfaces between the space shuttle orbiter and the AMPS payload are described for the ground handling and test phases, prelaunch, launch and ascent, operational, stowage, and reentry and landing activities.
Atmospheric, Magnetospheric and Plasmas in Space (AMPS) spacelab payload definition study. Volume 3: Interface control documents. Part 3: AMPS payload to instruments ICD
General physical, functional, and operational interface control requirements for instruments on the first AMPS payload are presented. Interface specifications are included to satisfy ground handling, prelaunch, launch, stowage, operation, and landing activities. Applicable supporting documentation to implement the information is also given.
Atmosphere, Magnetosphere and Plasmas in Space (AMPS). Spacelab payload definition study. Volume 3; book 1: AMPS equipment to orbiter ICD
The physical, thermal, and electrical interfaces that exist between Spacelab-AMPS Payload No.(TBD) and the orbiter are described.
Atmosphere, Magnetosphere and Plasmas in Space (AMPS). Spacelab payload definition study. Volume 3, book 2: AMPS equipment to Spacelab ICD
The interfaces between AMPS Payload No.(TBD) and Spacelab are described. The interfaces specified cover the AMPS physical, electrical, and thermal interfaces that are established to prescribe the standard Spacelab configuration required to perform the mission. If the configuration definition changes due to change of Spacelab equipment model, or serial numbers, then reidentification of the Labcraft payload may be required.
Atmosphere, Magnetosphere and Plasmas in Space (AMPS). Spacelab payload definition study. Volume 3, book 3: AMPS equipment to instruments (vector magnetometer) ICD
The electrical, mechanical, and environmental interfaces between the boom-mounted flux gate magnetometer and the AMPS/Spacelab are described.
Preliminary interface revision notice SD-152C update of section 8.3 of ICD 2-19001 for detached payloads
The payload interrogator provides full duplex communication between the orbiter and detached payloads. This capability includes transmission of commands to and the reception of telemetry data from such payloads. Both NASA (STDN and DSN) and DOD (SGLS) transmit/receive frequency pairs are available. In addition to two way RF communication, Ku band rendezvous radar is also available. The radar skin-tracks targets in the passive mode or actively tracks transponder equipped payloads. Characteristics referring to those orbiter avionics characteristics of which the payloads must be cognizant and requirements referring to specifications placed upon payload communication equipment are discussed.
TESS Science Data Products Description Document: EXP-TESS-ARC-ICD-0014 Rev D
This document describes data product formats and content that are produced primarily by the TESS Science Processing Operations Center (SPOC) at NASA Ames Research Center for archival to the Mikulski Archive for Space Telescopes (MAST) .
TESS Science Data Products Description Document: EXP-TESS-ARC-ICD-0014 Rev F
This document discusses data product formats that are produced primarily by the TESS Science Processing Operations Center (SPOC) at NASA Ames Research Center. Data products are sent to the TESS Science Operations Center (SOC) at MIT where they are disseminated to the Mikulski Archive for Space Telescopes (MAST) and the TESS Science Office (TSO).
Test Results for the SEA Ice Crystal Detector (ICD) under SLD Conditions at the NASA IRT
The Science Engineering Associates hot-wire Ice Crystal Detector was tested under Appendix C and Supercooled Large Drop Conditions at the NASA Icing Research Tunnel, with the purpose of comparing the measurements to the tunnel LWC calibration, and to test the performance of the mixed-phase retrievals of the probe. The liquid water content measured by the total water content sensor of the probe agreed well with the tunnel calibration over a wide range of MVDs, not unexpectedly since the tunnel was calibrated with a similar Multiwire hot-wire probe. A scale factor difference of about 7% was attributed to the lack of an efficiency correction for the Ice Crystal Detector at smaller median volume diameters, and typical sample area uncertainties of liquid water content devices. In addition, the simultaneous equations that are used to retrieve liquid and ice water contents were tested under liquid and glaciated conditions. Using constant ice and water efficiencies for each wire, the equations were found to produce a large and false ice water content retrieval in large median volume diameter liquid cases. By applying a liquid efficiency to the liquid water content sensor that varied with median volume diameter, retrievals were improved such that false ice water content was less than ±10% of the total water content out to the 460 μm median volume diameter limit of the testing. The probe was also tested in glaciated conditions by freezing out a small median volume diameter spray. Using constant ice efficiencies for the two sensors provided from aircraft measurements, the retrieved ice water content was about 40% higher than expected for the case presented, likely due to the ice efficiencies that were used from aircraft measurements of natural clouds being too low for the tunnel’s glaciated sprays. Application of ice efficiencies that vary with particle size and potentially other parameters will be explored for future improvement of retrievals.
Test Results for the SEA Ice Crystal Detector (ICD) under SLD Conditions at the NASA IRT
The Science Engineering Associates hot-wire Ice Crystal Detector was tested under Appendix C and Supercooled Large Drop Conditions at the NASA Icing Research Tunnel, with the purpose of comparing the measurements to the tunnel LWC calibration, and to test the performance of the mixed-phase retrievals of the probe. The liquid water content measured by the total water content sensor of the probe agreed well with the tunnel calibration over a wide range of MVDs, not unexpectedly since the tunnel was calibrated with a similar Multiwire hot-wire probe. A scale factor difference of about 7% was attributed to the lack of an efficiency correction for the Ice Crystal Detector at smaller median volume diameters, and typical sample area uncertainties of liquid water content devices. In addition, the simultaneous equations that are used to retrieve liquid and ice water contents were tested under liquid and glaciated conditions. Using constant ice and water efficiencies for each wire, the equations were found to produce a large and false ice water content retrieval in large median volume diameter liquid cases. By applying a liquid efficiency to the liquid water content sensor that varied with median volume diameter, retrievals were improved such that false ice water content was less than ±10% of the total water content out to the 460 μm median volume diameter limit of the testing. The probe was also tested in glaciated conditions by freezing out a small median volume diameter spray. Using constant ice efficiencies for the two sensors provided from aircraft measurements, the retrieved ice water content was about 40% higher than expected for the case presented, likely due to the ice efficiencies that were used from aircraft measurements of natural clouds being too low for the tunnel’s glaciated sprays. Application of ice efficiencies that vary with particle size and potentially other parameters will be explored for future improvement of retrievals.
A Preliminary Development of The Intelligent Change Detection System (ICDS): Using Machine Learning to Combat Change Blindness in Remote Operation Environments
The emergence of Advance Air Mobility (AAM) will increase the number and types of aerial vehicles operating in shared airspaces, which will subsequently affect the amount of actionable data that ground control station operators (GCSOs) will be expected to manage. In this environment, GCSOs are particularly susceptible to the visual perceptual phenomenon known as change blindness, in which a stimulus undergoes a change without the change being noticed by its observer. A machine agent designed to detect change blindness and mitigate the effects could improve human agent performance in a data-saturated remote operations environment. The objective of this paper is to describe a proof-of-concept system architecture that integrates real-time eye tracking and vehicle telemetry data to prevent human-agent errors resulting from change blindness while operating aircraft from a remote ground control station (GCS).