Search NASA⌕ Search

SEARCH · Search NASA

Results for “Current Controllers”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,261 records · Page 70

Recent developments in high purity niobium metal production at CBMM

CBMM is a global supplier of high quality niobium products including pure niobium, the focus of this paper. CBMM’s position has been consolidated over three decades of producing high purity niobium metal ingots. The company supplies, among other products, commercial and reactor grade niobium ingots. One of the main uses of CBMM’s ingots is for the manufacture of particle accelerators (superconducting radio frequency – SRF – cavities), where the purity and homogeneity of niobium metal is essentially important for good performance. CBMM constantly strives to improve process controls and product quality, and is currently implementing innovations in production, research and development to further improve ingot quality. The main aim is to reduce the content of interstitial elements, such as nitrogen (N), oxygen (O), carbon (C), and hydrogen (H), starting with the raw materials through the final step of ingot production. CBMM held the first trial to produce the world’s largest-diameter niobium ingot (as cast 535 mm). The results of this initial trial presented very low levels of interstitial impurities (N, O, C, H), allowing the achievement of residual resistivity ratio (RRR) values very close to 300 in a six-melt process in an electron beam furnace. These values were reached with 850 ppm of tantalum. SRF cavities will be produced with this material in order to study the effect of low impurities and high RRR on the Q factor and accelerating gradient.

43 PARTICLE ACCELERATORS↗

Capillary pinning and blunting of immiscible gravity currents in porous media

Gravity-driven flows in the subsurface have attracted recent interest in the context of geological carbon dioxide (CO 2 ) storage, where supercritical CO 2 is captured from the flue gas of power plants and injected underground into deep saline aquifers. After injection, the CO 2 will spread and migrate as a buoyant gravity current relative to the denser, ambient brine. Although the CO 2 and the brine are immiscible, the impact of capillarity on CO 2 spreading and migration is poorly understood. We previously studied the early time evolution of an immiscible gravity current, showing that capillary pressure hysteresis pins a portion of the macroscopic fluid–fluid interface and that this can eventually stop the flow. Here we study the full lifetime of such a gravity current. Using tabletop experiments in packings of glass beads, we show that the horizontal extent of the pinned region grows with time and that this is ultimately responsible for limiting the migration of the current to a finite distance. We also find that capillarity blunts the leading edge of the current, which contributes to further limiting the migration distance. Using experiments in etched micromodels, we show that the thickness of the blunted nose is controlled by the distribution of pore–throat sizes and the strength of capillarity relative to buoyancy. We develop a theoretical model that captures the evolution of immiscible gravity currents and predicts the maximum migration distance. By applying this model to representative aquifers, we show that capillary pinning and blunting can exert an important control on gravity currents in the context of geological CO 2 storage.

58 GEOSCIENCES↗

Integrated operation of steady-state long-pulse H-mode in Experimental Advanced Superconducting Tokamak

Recent Experimental Advanced Superconducting Tokamak (EAST) experiments have successfully demonstrated a long-pulse steady-state scenario with improved plasma performance through integrated operation since the last IAEA FEC in 2016. A discharge with a duration over 100 s using pure radio frequency (RF) power heating and current drive has been obtained with the required characteristics for future long-pulse tokamak reactors such as good energy confinement quality (H 98y2 ~ 1.1) with electron internal transport barrier inside ρ < 0.4, small ELMs (frequency ~100–200 Hz), and good control of impurity and heat exhaust with the tungsten divertor. The optimization of X-point, plasma shape, the outer gap and local gas puffing near the low hybrid wave (LHW) antenna were integrated with global parameters of BT and line-averaged electron density for higher current drive efficiency of LHW and on-axis deposition of electron cyclotron heating in the long-pulse operation. More recently, a high βP RF-only discharge (β P ~ 1.9 and β N ~ 1.5, $\langle$n e $\rangle$/n GW ~ 0.80, f bs ~ 45% at q 95 ~ 6.8) was successfully maintained over 24 s with improved hardware capabilities, demonstrating performance levels needed for the China Fusion Engineering Test Reactor steady-state operation. In this work, a higher energy confinement is observed at higher β P and with favorable toroidal field direction. Towards the next goal (≥400 s long-pulse H-mode operations with ~50% bootstrap current fraction) on EAST, an integrated control of the current density profile, pressure profile and radiated divertor will be addressed in the near future.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Public Reference Data for Megawatt-Scale Hydrogen Electrolysis - Simulated Marine Hydrokinetic Tidal Turbine

The U.S. Department of Energy and National Laboratory of the Rockies (NLR) demonstrate hydrogen electrolysis, hydrogen compression and storage, and variable hydrogen fuel cell power production using megawatt-scale equipment at NLR’s Flatirons Campus as part of the Advanced Research on Integrated Energy Systems (ARIES) initiative. This dataset is part of that effort and is intended for academic, national laboratory, industrial, and other stakeholders to plan, design, and validate models of megawatt-scale hydrogen technologies and diverse energy infrastructure. These data provide a baseline for how existing hydrogen electrolysis technologies perform when coupled with other energy technologies. This dataset contains inputs and outputs from simulations of a floating marine hydrokinetic turbine over approximately half a tidal cycle (~6.6 hours). Inflow conditions were derived from field measurements in Alaska’s Cook Inlet and represent a tidal environment in which the current speed ramps from near 0 m/s to a peak of 3 m/s and back. The original acoustic doppler current profiler dataset is publicly available on the Marine and Hydrokinetic Data Repository. In a full tidal cycle, the flow reverses and the rotor would reorient; this reversal was not modeled. In the Cook Inlet campaign , turbulence intensity was similar in both directions. Two inflow cases are included. In the first case, labeled “raw” in the files, the measured current time series was used directly in the InflowWind module of OpenFAST. Speed and direction were applied as a function of time and elevation, uniformly in the horizontal direction. With full spatial coherence, this approach captures high turbulent variability and results in pronounced power fluctuations, so it is considered a conservative, near-worst-case representation of loading. In the second case, labeled “average” in the files, a 30-minute moving average was applied to extract the slowly varying mean speed. The residual fluctuations about this mean were used to generate spatially varying, full-field turbulence inputs with TurbSim, giving a more physically realistic representation of the inflow across the rotor disk. Two random realizations were used to produce distinct inflow conditions for two OpenFAST simulations representing a two-turbine array. The same turbulence intensity is applied across the full time series, producing larger fluctuations at the start and end, where the mean speed is low. The second case is the more appropriate framework for performance and power assessment but overpredicts turbulence at lower flow speeds and underpredicts it at higher speeds. As the floating platform moves and the rotor changes its x-position, Taylor’s frozen turbulence hypothesis used by InflowWind assumes a constant rather than a time-varying mean velocity, introducing some inaccuracy in the velocity plane sampling. The turbine modeled is the 500-kW Reference Model 1, a horizontal-axis two-bladed hydrokinetic turbine on a four-column floating semisubmersible substructure . Simulations were performed using OpenFAST v4.1 with the Reference Open Source Controller (ROSCO) v2.10. All input files required to reproduce the simulations are included. The electrolyzer is a 1.25-MW proton exchange membrane type MC250 system manufactured by Nel . This unit supports up to 2.5 MW, but NLR has only a single 1.25-MW stack. The datasets report hydrogen balance-of-plant and system data, all captured at 1 Hz, including hydrogen mass production measured with an Emerson Coriolis flow meter. The system controls hydrogen production by varying direct current applied to the stack, from a maximum of 3,000 A to a minimum safe operating current of 300 A, or 10%. Because the current–voltage characteristic changes as the stack ages and efficiency degrades, the actual minimum safe operating power changes over time. The simulated tidal turbine time series data was translated from power (kilowatts) to current (amperes) using a curve fit with calibration data and sent to the electrolyzer power supply at 1-Hz. Each zip file represents a single tidal electrolysis experiment and is named: {technology}_{inflow method}_{number of 500 kW tidal turbines connected} For instance, “tidal-500kW-RM1_average_2.zip” is a 6-hour experiment using the 500-kW tidal reference model, scaled by 2x (1-MW) to better match the electrolyzer maximum of 1.25MW, fed with the 30-minute moving average current case. Each zip folder contains the following files: A .csv file of raw data. An .xlsx file explaining all the fields in the raw data. A .png plot showing the time series of hydrogen production in kilograms per hour, electrolysis power consumption, and input wave power. A .csv file combines all tidal profiles as "combined_tidal_experiments.csv." A separate experiment, “characterization_200.zip,” shows the MC250 electrolyzer steady-state response with 30-minute load steps over 5 hours and is accessible with this entry.

08 HYDROGEN↗

Dissipativity-based design of local and wide-area DER controls for large-scale power systems with high penetration of renewables

In this paper, an integrated and modular control design is developed for distributed energy resources (DERs) to stabilize power systems and minimize effects of load variations and intermittent generation. Traditionally, the droop control of each generator (or virtual power plant) works as a local feedback loop to track frequency during load disturbance, whereas automatic generation control (AGC) calculates control signals and sends them to each generator with the goal of matching the total generation and load in the overall system. The droop control and the AGC work separately, therefore the two controls often conflict each other. The proposed design enables us to modularly synthesize an integrated control for each of the DERs by using both local and wide-area measurements so that the controls work together in enhancing stability and performance of the power system. The design methodology admits the full nonlinear power flow equations, and it results in a data-driven control that in real-time takes into account the nonlinear power flow interactions (in terms of current angle measurements) and adaptively adjusts parameters of the controls that operate the DERs. The design framework uses the concept of passivity-short systems to analyze individual DERs and quantify their dynamic responses in such a way that the resulting system-wide implementation becomes plug-and-play. Simulations are done to demonstrate the effectiveness of the proposed methodology and design.

Harvey, Roland↗

Predictive Self-Healing Seals for Gas Transmission

Damaged elastomeric diaphragms within pneumatic controllers used in the oil and gas industry lead to an unintended release of methane. Self-healing microvascular materials capable of healing various types of damage have been fabricated. These microvascular materials are designed to replace currently available commercial diaphragms found in pneumatic controllers and provide a solution to reduce unintended methane leaks. This project demonstrated the ability of these materials to reduce methane release by more than 80% in lab and pilot settings. Additionally, ML approaches successfully identified leaking systems based on training using synthetic and real data.

03 NATURAL GAS↗

ELASTOMERIC MICROVASCULAR SELF-HEALING MATERIALS

Damaged elastomeric diaphragms within pneumatic controllers used in the oil and gas industry lead to an unintended release of methane. Self-healing microvascular materials capable of healing various types of damage have been fabricated. These microvascular materials are designed to replace currently available commercial diaphragms found in pneumatic controllers and provide a solution to reduce unintended methane leaks. Poly(dimethylsiloxane) (PDMS) was used as the main matrix material, with additional testing conducted on polyurethane and flexibilised epoxy materials. Microvascular networks were implemented into the elastomeric membranes to act as ves- sels to deliver healing agents to the damaged areas. The complex, interdigitated channel networks were created using a 3D printed custom compounded filament composed of polylactic acid (PLA) and tin(II) oxalate. Two-part liquid casting polymers were poured around the channels into a mould to create samples with the scaffolding of the microvascular channels intact. Hollow microvascular networks were created by placing the samples within a vacuum oven at 250◦C which causes the thermal depolymerisation of PLA into its gaseous monomers. The manufactured materials were placed in test stands and pressurized using nitrogen gas to determine their healing and mechanical behaviour. Self-healing behaviour was demonstrated using PDMS matrix materials and healing chemistries within a pressure test cell. This test cell was designed to detect any damage to a sample by record- ing an outlet pressure. Damages including puncture holes, diagonal cuts and star-shaped central iv cuts were applied to the samples and a reduction in the outlet pressure was recorded for all sam- ples. A variation in channel spacing and diameter was studied to determine the optimal design of the microvascular network for self-healing performance. The mechanical performance of elastomeric membrane materials within a diaphragmatic pressurised stand was observed. Deformations and strains around the channels and channel inter- sections at the midplane of the materials were recorded using digital image correlation. Normal stresses were calculated using Hooke’s law and the material properties of the PDMS matrix. A reduction in leak rate, implying the success of self-healing, was recorded within manu- factured diaphragm samples tested within a commercial valve. PDMS is the favourable material when compared to polyurethane and flexibilised epoxy for creating

03 NATURAL GAS↗

Development of Tunable, Precision Permanent Magnet Phase Shifter for X-Ray FEL

In an X-ray free-electron laser (XFEL), a high quality relativistic electron beam from a linear accelerator traverses an array of undulator magnets to generate a high power X-ray beam by allowing the FEL to reach saturation. In many XFELs, phase shifters haven’t been commonly used or included in their designs. The importance of the phase shifter was recognized only recently. A phase shifter can be constructed using either an electromagnet (EM) or a permanent magnet (PM). EM phase shifters are heavy, complex to operate, and take more valuable longitudinal space between the undulators. Compared to EMs, the PMs have several outstanding advantages, including compactness, lighter weights, simple operation, and low maintenance. This project has developed an innovative design of fixed-gap, tunable PM-based compact phase shifter for the XFEL. While keeping the poles and gap fixed, the new design incorporates proven features from the prior work, along with novel field tuning methods, which allow the field strength to be adjusted within a reasonably large range to achieve the desired range of the phase delay control. The PM design without electric currents and power electronics associated with EMs improves reliability by reducing the number of possible points of failure and lowers the operation cost. The compactness makes it possible to use PM phase shifters in the existing XFELs with small gaps between adjacent undulators, as well as in the new XFELs without significantly increasing the FEL length. In Phase I we have accomplished the followings; 1) determined the optimum physics parameters for both weak and strong phase shifters; 2) conducted magnetic design with concrete magnetic and geometrical parameters of actual produced PM materials; 3) provided solutions to achieve precision fine tuning of the magnetic fields with unique methods; 4) elaborated a design based upon ease of manufacturing and cost analysis; and 5) produced rare-earth PM materials, which will be used for prototyping in Phase II. The phase I results provide a foundation for the research and development in the Phase II project, which will aim at building two full-size PM phase shifters and testing at SLAC National Accelerator Laboratory. This project will significantly provide the potential to bring a paradigm change in accelerator technology, replacing conventional electromagnets for many existing accelerator applications and allowing the development of new applications in completely new areas. For example, the PM FEL phase shifters can help significantly improve coherence and power of an XFEL. The proposed use of PM phase shifters will also bring significant cost savings to the construction, operation and maintenance of FEL facilities.

43 PARTICLE ACCELERATORS↗

Dynamic Load Inrush Current Mitigation in Islanded Microgrids Powered by Grid-Forming Inverters

Grid-forming inverters in a microgrid may trip due to high inrush current caused by a switched connection of an inductive load, e.g., a relatively large induction motor. The control scheme presented in this article includes virtual inertia control method superimposed on the cascaded controller. This article studies the impact of cascaded control scheme used for grid-forming inverter to mitigate the inrush current effects and enhance the inverter’s robustness for the safe connection of inductive and dynamic loads. Experimental tests are performed using the virtual inertia method for generating the reference angle for synchronous frame conversion. The experimental performance and sensitivity of the controller to different controller gain settings for a switched connection of an induction motor are discussed. The cascaded operation significantly mitigates the inrush currents while the inverters can perform a normal operation. The performance of the control method is tested in a laboratory-scale hardware setup of a 208V microgrid fed by 5kVA and 10kVA inverters, and the results are presented.

Gursoy, Mehmetcan↗

Automated x-ray/light field congruence using the LINAC EPID panel

Purpose: X-ray/light field alignment is a test described in many guidelines for the routine quality control of clinical linear accelerators (LINAC). Currently, the gold standard method for measuring alignment is through utilization of radiographic film. However, many modern LINACs are equipped with an electronic portal imaging device (EPID) that may be used to perform this test and thus subsequently reducing overall cost, processing, and analysis time, removing operator dependency and the requirement to sustain the departmental film processor. Methods: This work describes a novel method of utilizing the EPID together with a custom inhouse designed jig and automatic image processing software allowing measurement of the light field size, x-ray field size, and congruence between them. The authors present results of testing the method for aS1000 and aS500 Varian EPID detectors for six LINACs at a range of energies (6, 10, and 15 MV) in comparison with the results obtained from the use of radiographic film. Results: Reproducibility of the software in fully automatic operation under a range of operating conditions for a single image showed a congruence of 0.01 cm with a coefficient of variation of 0. Slight variation in congruence repeatability was noted through semiautomatic processing by four independent operators due to manual marking of positions on the jig. Testing of the methodology using the automatic method shows a high precision of 0.02 mm compared to a maximum of 0.06 mm determined by film processing. Intraindividual examination of operator measurements of congruence was shown to vary as much as 0.75 mm. Similar congruence measurements of 0.02 mm were also determined for a lower resolution EPID (aS500 model), after rescaling of the image to the aS1000 image size. Conclusions: The designed methodology was proven to be time efficient, cost effective, and at least as accurate as using the gold standard radiographic film. Additionally, congruence testing can be easily performed for all four cardinal gantry angles which can be difficult when using radiographic film. Therefore, the authors propose it can be used as an alternative to the radiographic film method allowing decommissioning of the film processor.

60 APPLIED LIFE SCIENCES↗

Strengthening Cybersecurity for Industrial Control Systems: Innovations in Protecting PLC-Based Infrastructure

In this paper, we propose two new approaches aimed at enhancing the security of industrial control systems (ICS) that utilize programmable logic controllers (PLCs) for the control of critical processes. The first approach involves the addition of a unique digital watermark to the PWM control that adjusts the motor speed to control the critical process. This enables efficient detection and identification of any unauthorized modifications to the sensor signals responsible for controlling the plant. The second approach focuses on monitoring the input current (i.e power) drawn by the PLC during the execution of critical process control tasks. Malicious intrusions to change the PLC parameters and/or unauthorized firmware updates can be rapidly detected. Both approaches demonstrate a substantial improvement in the security of ICS, effectively safeguarding against potential cyber-attacks. Experimental results from a laboratory scale water tank level controlled via PLC showcases rapid intrusion detection capabilities.

Huang, Peng-Hao↗

Relationship Between the Marginal Probability of Failure for a CPP Test and the Recommended Corrosion Control Requirements for Hanford Double Shell Waste Tanks

The Hanford Site in Washington State currently stores millions of gallons of radioactive waste in underground, carbon steel, double shell tanks (DSTs) that were constructed between 1968 and 1986. A chemistry control and monitoring program has been established mitigate corrosion in order to extend the service life for the DSTs. The current waste temperatures in the DSTs are at historical lows (i.e., typically less than 50 °C). The previous chemistry control requirements were determined for conditions at temperatures significantly higher. SRNL undertook a statistically based investigation of the role of nitrate and halide ion (i.e., chloride and fluoride) induced pitting corrosion. The objective was to develop a comprehensive waste chemistry envelope for the simultaneous minimization of the pitting and SCC risks caused by halide and nitrate ions at the lower temperature conditions. On the basis of these tests, new chemistry control requirements were proposed and have since been implemented for pitting corrosion control.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

BTO 3.1.2.55 Milestone Report – Report of Literature Review for Maldistribution in Heat Exchangers

In this quarter, a comprehensive review of the literature was performed to understand the effects of flow maldistribution and current efforts to improve performance through flow control. Nearly all systems have some degree of maldistribution on either the air-side, refrigerant-side, or both. Air-side maldistribution was found to have a greater impact on heat exchanger performance compared to refrigerant-side, but both sides of the system are important to consider when developing solutions. Up to a maximum of 65% capacity loss was reported in large commercial systems due to air-side maldistribution. Microchannel heat exchangers are becoming more widespread due to their efficiency and size but are even more prone to maldistribution than conventional fin-tube heat exchangers. Current solutions tend to focus on optimizing header design and refrigerant circuitry to improve performance. Several active control methods, such as hybrid control, have been explored to control refrigerant flow in real time, but there is a need for an adaptive yet cost effective system which can optimize performance in changing conditions.

42 ENGINEERING↗

Comparative Evaluation of the Single-Phase Shift and Extended-Phase Shift Control for Isolated DC-DC Converter

Abstract: This paper presents a comparative evaluation of the Single-Phase Shift (SPS) and Extended-Phase Shift (EPS) controls for the isolated DC-DC Converter. The analysis is based on the power regulation range, flexibility of operation, current stress on power devices, system efficiency while focusing on the issue of backflow power, control complexity, design and implementation overhead, and stability of the entire system. It is also examined how the backflow influences power circulation and increases current stress. Here, the Dual Active Bridge (DAB) Converter is employed to assess the performance of the control methods. Compared to SPS control, EPS offers a wider power regulation range, greater flexibility, lower current stress, and better system efficiency. However, EPS has increased control complexity, design and implementation overhead, and often requires sophisticated feedback control loops. The comparison is made through mathematical modeling of power transfer, backflow, and current stress. Simulation results validate the comparative analysis presented.

Amir, Aamir [The University of Alabama (UA)]↗

Resilient Inverter-Driven Black Start with Collective Parallel Grid-Forming Operation

As modern power systems are experiencing exceptional changes with increasing penetrations of inverter-based resources (IBRs), system restoration using IBRs has received attention. Using local grid-forming (GFM) assets near consumers, engineered to establish grid voltages in the absence of a stiff grid, i.e., bottom-up restoration, a distribution system could obtain high system resilience by not relying on the bulk power system restoration, which requires significant human intervention and procedure. This paper studies the technical feasibility of the novel approach with detailed electromagnetic transient (EMT) simulations. To thoroughly evaluate the potential of GFM inverters and the technical challenges in IBR-driven black start, a detailed three-phase inverter model is developed, including negative-sequence control for voltage balance and a phase-by- phase current limiter to sustain momentary overloading during the black start. To examine dynamic aspects of the black-start process, the EMT simulation also models transformer and motor dynamics to emulate their inrush and startup behaviors as well as network dynamics. In addition, active involvement of grid- following distributed energy resources is also studied to facilitate the black-start process. By allowing multiple GFM inverters to collectively black start without leader-follower coordination, we demonstrate that a system can achieve high resilience even with a fraction of assets lost. Two test cases of inverter-driven black start, using two and one GFM inverters, respectively, for a heavily unbalanced 2-MVA distribution feeder are demonstrated. Takeaways for further study and field deployment are provided.

grid-forming inverter↗

Resilient Inverter-Driven Black Start with Collective Parallel Grid-Forming Operation: Preprint

As the modern power systems are experiencing exceptional changes with increasing penetration of inverter-based resources (IBRs), system restoration using IBRs has received attention. Using local grid-forming (GFM) assets near consumers, engineered to establish grid voltages in the absence of a stiff grid, i.e., bottom-up restoration, a distribution system would obtain high system resilience, by not relying on the bulk power system restoration requiring significant human intervention and procedure to restore. This paper studies the technical feasibility of the novel approach with detailed electromagnetic transient (EMT) simulations. To thoroughly evaluate the potential of GFM inverters and technical challenges in IBR-driven black start, a detailed three-phase inverter model is developed, including negative-sequence control for voltage balance and a phase-by-phase current limiter to sustain momentary overloading during the black start. To examine dynamic aspects of the black start process, the EMT simulation also models transformer and motor dynamics to emulate their inrush and start-up behaviors as well as network dynamics. In addition, active involvement of grid-following distributed energy resources (DER) is also studied to facilitate the black start process. It is shown that, by allowing multiple GFM inverters to collectively black start without master-slave coordination, a system can achieve high resilience even with a fraction of assets lost. Two test cases of inverter-driven black start using two and one GFM inverters, respectively, for a heavily unbalanced 2-MVA distribution feeder are demonstrated. Takeaways for further study and field deployment are provided.

grid-forming inverter↗

Metal nanoparticle mediated space charge and its optical control in an organic hole-only device

We reveal the role of localized space charges in hole-only devices based on an organic semiconductor with embedded metal nanoparticles (MNPs). MNPs act as deep traps for holes and reduce the current density compared to a device without MNPs by a factor of 10{sup 4} due to the build-up of localized space charge. Dynamic MNPs charged neutrality can be realized during operation by electron transfer from excitons created in the organic matrix, enabling light sensing independent of device bias. In contrast to the previous speculations, electrical bistability in such devices was not observed.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Antiaging activity, molecular docking, and prediction of percutaneous absorption parameters of quinoline–hydrazone hybrids

The application of antiaging agents can contribute to the prevention and control of skin photoaging. In the current research, nine quinoline–hydrazone hybrids were synthesized to obtain biologically active compounds as possible antiaging agents. The compounds were tested through a comprehensive in vitro evaluation of antielastase, anticollagenase, and antihyaluronidase activities along with the determination of their potential to quench reactive oxygen species (ROS) by the ORAC method. The selected hybrids were subsequently tested on human dermal fibroblasts (HDF) to reveal possible UVB photoprotective activity. The most potent antiaging protection of all the prepared compounds was shown by the trihydroxylated quinoline–hydrazones 5 and 9, which showed the best collagenase inhibition (IC{sub 50} = 39.4 and 45.6 µM, respectively). Compound 5 also showed activity against elastase and hyaluronidase (IC{sub 50} = 164.2 and 318.8 µM, respectively). The molecular docking results suggest that the difference of inhibition between 5 and 9 is principally attributed to the hydrogen bonds interactions in the residues His218 and His228, and Zn atom in collagenase, Val216 in elastase and Tyr75 in hyaluronidase. In addition, compounds 5 and 9 were able to significantly protect human skin cells from UVB radiation in vitro. These compounds significantly decreased UVB-induced MMP-1 and ROS production and inhibited the suppression of type I procollagen synthesis in cultured HDF. The in silico dermatopharmacokinetic parameters showed promising results. Therefore, our study presented promising results for antiaging drug discovery, focusing on quinoline–hydrazone hybrids as dual inhibitors of skin aging-related enzymes, antioxidants, and inhibitors of the biological effects of UVB irradiation.

60 APPLIED LIFE SCIENCES↗